Abstract
The aim of this study was to determine the uptake of intravenously administered N-[(11)CH(3)]-dimethylaminoparthenolide (DMAPT) into orthotopic 9LSF glioblastoma brain tumors in Fisher 344 rats from positron emission tomography (PET) imaging studies. [(11)C]methyl iodide ((11)CH(3)I) was utilized as a [(11)C]-labeling reagent to label the precursor methylaminoparthenolide (MAPT) intermediate. From PET imaging studies it was found that brain uptake of N-[(11)CH(3)]DMAPT into brain tumor tissue was rapid (30min), and considerably higher than that in the normal brain tissue.