A highly promising new avenue for targeting K-RAS: The small-molecule degrader XMU-MP-9

靶向K-RAS的一种极具前景的新途径:小分子降解剂XMU-MP-9

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Abstract

To address ammonium nitrogen (NH(4)(+)-N) and nitrite accumulation in intensive marine shrimp aquaculture, a marine recirculating aquaculture system (RAS) for Penaeus vannamei centered on a moving bed biofilm reactor (MBBR) was constructed to investigate the microbial basis of nitrogen removal. The results showed that the MBBR contributed most to NH(4)(+)-N removal, demonstrating favorable nitrification potential under marine conditions (0.513 mg·L(−1)·h(−1)). The biofilm carrier formed a complete attached layer and developed a mature biofilm structure. Microbial community analysis revealed clear differentiation between the biofilm and sediment. The biofilm community was dominated by norank_f__Caldilineaceae (9.89%). Linear discriminant analysis effect size identified the nitrifying genus Nitrospira to be significantly enriched on the biofilm side (α = 0.05, linear discriminant analysis > 2.0). In addition, PICRUSt2-based functional prediction suggested a higher potential in biofilm than in sediment for ammonia oxidation and downstream nitrogen transformation, involving ammonia monooxygenase (EC:1.14.99.39), hydroxylamine dehydrogenase (EC:1.7.2.6), nitrate reductase (EC:1.7.99.4), and nitrite reductase (EC:1.7.2.1). Thus, this study provides a microbial basis and process strategy for P. vannamei RAS.

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