Human Infant Memory B Cell and CD4+ T Cell Responses to HibMenCY-TT Glyco-Conjugate Vaccine

人类婴儿记忆 B 细胞和 CD4+ T 细胞对 HibMenCY-TT 糖结合疫苗的反应

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作者:Angela Fuery, Peter C Richmond, Andrew J Currie

Conclusion

Induction of persistent polysaccharide-specific memory B cells prior to boosting is an important determinant of secondary IgG responses in infants. However, polysaccharide-specific functional IgG responses appear to be independent of the number and quality of circulating carrier-specific CD4+ T cells after priming.

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