SWI/SNF remains localized to chromatin in the presence of SCHLAP1
在 SCHLAP1 存在的情况下，SWI/SNF 仍然定位于染色质
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作者：Jesse R Raab, Keriayn N Smith, Camarie C Spear, Carl J Manner, J Mauro Calabrese, Terry Magnuson
| 期刊： | Nature Genetics | 影响因子： | 31.700 |
| 时间： | 2019 | 起止号： | 2019 Jan;51(1):26-29. |
| doi： | 10.1038/s41588-018-0272-z | 方法学： | ChIP |
| 靶点： | PB1 | 研究方向： | 信号转导 |
Abstract
SCHLAP1 is a long noncoding RNA that is reported to function by depleting the SWI/SNF complex from the genome. We investigated the hypothesis that SCHLAP1 affects only specific compositions of SWI/SNF. Using several assays, we found that SWI/SNF is not depleted from the genome by SCHLAP1 and that SWI/SNF is associated with many coding and noncoding RNAs, suggesting that SCHLAP1 may function in a SWI/SNF-independent manner.
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