Abstract
STUDY DESIGN: Retrospective observational study. PURPOSE: To analyze the clinical outcomes of patients with deep stromal fungal keratitis with endoexudates who received adjuvant anterior chamber (AC) wash with intracameral (IC) and intrastromal (IS) voriconazole. METHODS: Demographics, risk factors, clinical course, microbiology, and visual outcomes of patients with deep-seated fungal keratitis who underwent AC wash with IC and IS voriconazole from January 2022 to December 2022 with at least 6 months post-op follow-up visits were analyzed. RESULTS: The mean age of 40 patients was 53 ± 12 years, and the mean time to presentation was 12 ± 8 days. The mean size of the ulcer at presentation was 21 ± 11.7 square mm. Aspergillus flavus was the most isolated organism in 16 (40%) patients. Seven (17.5%) patients achieved complete resolution with scarring and 33 (82.5%) required therapeutic keratoplasty (TPK), out of which 10 (30.3%) had reinfection. CONCLUSION: AC wash with IC and IS voriconazole was ineffective as adjuvant therapy in cases of deep-seated fungal keratitis.