Selective detection of bacteria in urine with a long-range surface plasmon waveguide biosensor

使用长距离表面等离子体波导生物传感器选择性检测尿液中的细菌

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作者:Paul Béland, Oleksiy Krupin, Pierre Berini

Abstract

Experimentation demonstrates long-range surface plasmon polariton waveguides as a useful biosensor to selectively detect gram negative or gram positive bacteria in human urine having a low concentration of constituents. The biosensor can detect bacteria at concentrations of 10(5) CFU/ml, the internationally recommended threshold for diagnostic of urinary tract infection. Using a negative control urine solution of bacterial concentration 1000☓ higher than the targeted bacteria, we obtain a ratio of 5.4 for the positive to negative signals.

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