Expression of Stem Cell Markers in Preinvasive Tubal Lesions of Ovarian Carcinoma
卵巢癌输卵管浸润前病变中干细胞标志物的表达
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作者:G Chene, V Ouellet, K Rahimi, V Barres, L Meunier, M De Ladurantaye, D Provencher, A M Mes-Masson
| 期刊: | Biomed Research International | 影响因子: | 2.600 |
| 时间: | 2015 | 起止号: | 2015:2015:808531. |
| doi: | 10.1155/2015/808531 | 方法学: | FCM、IF、IHC-P |
| 靶点: | P53 | 研究方向: | 发育与干细胞、肿瘤 |
| 疾病类型: | 卵巢癌 | 细胞类型: | 干细胞 |
Abstract
In order to better understand the ovarian serous carcinogenic process with tubal origin, we investigated the expression of stem cell markers in premalignant tubal lesions (serous tubal intraepithelial carcinoma or STIC). We found an increased stem cell marker density in the normal fallopian tube followed by a high CD117 and a low ALDH and CD44 expression in STICs raising the question of the role of the stem cell markers in the serous carcinogenic process.
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