Nitric Oxide Activates Apoptosis Signal - Regulating Kinase 1 (ASK 1) Forming S-Nitrosothiols with Reactive Thioredoxin SH-Groups. Nitric Oxide Synthase (NOS) Induction Mediated Inhibition of Poly-(ADP-RIBOSE)-Polymerase (PARP) and Protein Kinase C (PKC) Activities as well as Intranucleosomal DNA Fragmentation (IDF) Increase in the HEP-2 Cells

一氧化氮激活凋亡信号调节激酶1 (ASK1)，与活性硫氧还蛋白的巯基形成S-亚硝基硫醇。一氧化氮合酶 (NOS) 诱导介导聚（ADP-核糖）聚合酶 (PARP) 和蛋白激酶C (PKC) 活性的抑制，以及HEP-2细胞中核内DNA片段化 (IDF) 的增加。