2-cinnamamido, 2-(3-phenylpropiolamido), and 2-(3-phenylpropanamido)benzamides: synthesis, antiproliferative activity, and mechanism of action
2-肉桂酰胺、2-(3-苯基丙酰胺)和 2-(3-苯基丙酰胺)苯甲酰胺：合成、抗增殖活性和作用机制
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作者：Demetrio Raffa, Benedetta Maggio, Maria Valeria Raimondi, Maria Grazia Cusimano, Giandomenico Amico, Anna Carollo, Pier Giulio Conaldi, Ruoli Bai, Ernest Hamel, Giuseppe Daidone
Abstract
Several new benzamides 4a-q were synthesized by stirring in pyridine the acid chlorides 3a-q with the appropriate anthranilamide derivatives 2a-g. Some of the synthesized compounds were evaluated for their in vitro antiproliferative activity against a panel of 5 human cell lines (K562 human chronic myelogenous leukemia cells, MCF-7 breast cancer cells, HTC-116 and HT26 colon cancer cells and NCI H460 non-small cell lung cancer cells).
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