Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals

糖尿病患者和非糖尿病患者肾功能遗传效应的差异和共同之处

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作者：Winkler,Thomas W,Rasheed,Humaira,Teumer,Alexander,Gorski,Mathias,Rowan,Bryce X,Stanzick,Kira J,Thomas,Laurent F,Tin,Adrienne,Hoppmann,Anselm,Chu,Audrey Y,Tayo,Bamidele,Thio,Chris H L,Cusi,Daniele,Chai,Jin-Fang,Sieber,Karsten B,Horn,Katrin,Li,Man,Scholz,Markus,Cocca,Massimiliano,Wuttke,Matthias,van der Most,Peter J,Yang,Qiong,Ghasemi,Sahar,Nutile,Teresa,Li,Yong,Pontali,Giulia,Günther,Felix,Dehghan,Abbas,Correa,Adolfo,Parsa,Afshin,Feresin,Agnese,de Vries,Aiko P J,Zonderman,Alan B,Smith,Albert V,Oldehinkel,Albertine J,De Grandi,Alessandro,Rosenkranz,Alexander R,Franke,Andre,Teren,Andrej,Metspalu,Andres,Hicks,Andrew A,Morris,Andrew P,Tönjes,Anke,Morgan,Anna,Podgornaia,Anna I,Peters,Annette,Körner,Antje,Mahajan,Anubha,Campbell,Archie,Freedman,Barry I,Spedicati,Beatrice,Ponte,Belen,Schöttker,Ben,Brumpton,Ben,Banas,Bernhard,Krämer,Bernhard K,Jung,Bettina,Åsvold,Bjørn Olav,Smith,Blair H,Ning,Boting,Penninx,Brenda W J H,Vanderwerff,Brett R,Psaty,Bruce M,Kammerer,Candace M,Langefeld,Carl D,Hayward,Caroline,Spracklen,Cassandra N,Robinson-Cohen,Cassianne,Hartman,Catharina A,Lindgren,Cecilia M,Wang,Chaolong,Sabanayagam,Charumathi,Heng,Chew-Kiat,Lanzani,Chiara,Khor,Chiea-Chuen,Cheng,Ching-Yu,Fuchsberger,Christian,Gieger,Christian,Shaffer,Christian M,Schulz,Christina-Alexandra,Willer,Cristen J,Chasman,Daniel I,Gudbjartsson,Daniel F,Ruggiero,Daniela,Toniolo,Daniela,Czamara,Darina,Porteous,David J,Waterworth,Dawn M,Mascalzoni,Deborah,Mook-Kanamori,Dennis O,Reilly,Dermot F,Daw,E Warwick,Hofer,Edith,Boerwinkle,Eric,Salvi,Erika,Bottinger,Erwin P,Tai,E-Shyong,Catamo,Eulalia,Rizzi,Federica,Guo,Feng,Rivadeneira,Fernando,Guilianini,Franco,Sveinbjornsson,Gardar,Ehret,Georg,Waeber,Gerard,Biino,Ginevra,Girotto,Giorgia,Pistis,Giorgio,Nadkarni,Girish N,Delgado,Graciela E,Montgomery,Grant W,Snieder,Harold,Campbell,Harry,White,Harvey D,Gao,He,Stringham,Heather M,Schmidt,Helena,Li,Hengtong,Brenner,Hermann,Holm,Hilma,Kirsten,Holgen,Kramer,Holly,Rudan,Igor,Nolte,Ilja M,Tzoulaki,Ioanna,Olafsson,Isleifur,Martins,Jade,Cook,James P,Wilson,James F,Halbritter,Jan,Felix,Janine F,Divers,Jasmin,Kooner,Jaspal S,Lee,Jeannette Jen-Mai,O'Connell,Jeffrey,Rotter,Jerome I,Liu,Jianjun,Xu,Jie,Thiery,Joachim,Ärnlöv,Johan,Kuusisto,Johanna,Jakobsdottir,Johanna,Tremblay,Johanne,Chambers,John C,Whitfield,John B,Gaziano,John M,Marten,Jonathan,Coresh,Josef,Jonas,Jost B,Mychaleckyj,Josyf C,Christensen,Kaare,Eckardt,Kai-Uwe,Mohlke,Karen L,Endlich,Karlhans,Dittrich,Katalin,Ryan,Kathleen A,Rice,Kenneth M,Taylor,Kent D,Ho,Kevin,Nikus,Kjell,Matsuda,Koichi,Strauch,Konstantin,Miliku,Kozeta,Hveem,Kristian,Lind,Lars,Wallentin,Lars,Yerges-Armstrong,Laura M,Raffield,Laura M,Phillips,Lawrence S,Launer,Lenore J,Lyytikäinen,Leo-Pekka,Lange,Leslie A,Citterio,Lorena,Klaric,Lucija,Ikram,M Arfan,Ising,Marcus,Kleber,Marcus E,Francescatto,Margherita,Concas,Maria Pina,Ciullo,Marina,Piratsu,Mario,Orho-Melander,Marju,Laakso,Markku,Loeffler,Markus,Perola,Markus,de Borst,Martin H,Gögele,Martin,Bianca,Martina La,Lukas,Mary Ann,Feitosa,Mary F,Biggs,Mary L,Wojczynski,Mary K,Kavousi,Maryam,Kanai,Masahiro,Akiyama,Masato,Yasuda,Masayuki,Nauck,Matthias,Waldenberger,Melanie,Chee,Miao-Li,Chee,Miao-Ling,Boehnke,Michael,Preuss,Michael H,Stumvoll,Michael,Province,Michael A,Evans,Michele K,O'Donoghue,Michelle L,Kubo,Michiaki,Kähönen,Mika,Kastarinen,Mika,Nalls,Mike A,Kuokkanen,Mikko,Ghanbari,Mohsen,Bochud,Murielle,Josyula,Navya Shilpa,Martin,Nicholas G,Tan,Nicholas Y Q,Palmer,Nicholette D,Pirastu,Nicola,Schupf,Nicole,Verweij,Niek,Hutri-Kähönen,Nina,Mononen,Nina,Bansal,Nisha,Devuyst,Olivier,Melander,Olle,Raitakari,Olli T,Polasek,Ozren,Manunta,Paolo,Gasparini,Paolo,Mishra,Pashupati P,Sulem,Patrick,Magnusson,Patrik K E,Elliott,Paul,Ridker,Paul M,Hamet,Pavel,Svensson,Per O,Joshi,Peter K,Kovacs,Peter,Pramstaller,Peter P,Rossing,Peter,Vollenweider,Peter,van der Harst,Pim,Dorajoo,Rajkumar,Sim,Ralene Z H,Burkhardt,Ralph,Tao,Ran,Noordam,Raymond,Mägi,Reedik,Schmidt,Reinhold,de Mutsert,Renée,Rueedi,Rico,van Dam,Rob M,Carroll,Robert J,Gansevoort,Ron T,Loos,Ruth J F,Felicita,Sala Cinzia,Sedaghat,Sanaz,Padmanabhan,Sandosh,Freitag-Wolf,Sandra,Pendergrass,Sarah A,Graham,Sarah E,Gordon,Scott D,Hwang,Shih-Jen,Kerr,Shona M,Vaccargiu,Simona,Patil,Snehal B,Hallan,Stein,Bakker,Stephan J L,Lim,Su-Chi,Lucae,Susanne,Vogelezang,Suzanne,Bergmann,Sven,Corre,Tanguy,Ahluwalia,Tarunveer S,Lehtimäki,Terho,Boutin,Thibaud S,Meitinger,Thomas,Wong,Tien-Yin,Bergler,Tobias,Rabelink,Ton J,Esko,Tõnu,Haller,Toomas,Thorsteinsdottir,Unnur,Völker,Uwe,Foo,Valencia Hui Xian,Salomaa,Veikko,Vitart,Veronique,Giedraitis,Vilmantas,Gudnason,Vilmundur,Jaddoe,Vincent W V,Huang,Wei,Zhang,Weihua,Wei,Wen Bin,Kiess,Wieland,März,Winfried,Koenig,Wolfgang,Lieb,Wolfgang,Gao,Xin,Sim,Xueling,Wang,Ya Xing,Friedlander,Yechiel,Tham,Yih-Chung,Kamatani,Yoichiro,Okada,Yukinori,Milaneschi,Yuri,Yu,Zhi,Stark,Klaus J,Stefansson,Kari,Böger,Carsten A,Hung,Adriana M,Kronenberg,Florian,Köttgen,Anna,Pattaro,Cristian,Heid,Iris M
期刊：Communications Biology影响因子：5.100
时间：2022起止号：2022 Jun 13;5(1):580
doi：10.1038/s42003-022-03448-z

Abstract

Reduced glomerular filtration rate (GFR) can progress to kidney failure. Risk factors include genetics and diabetes mellitus (DM), but little is known about their interaction. We conducted genome-wide association meta-analyses for estimated GFR based on serum creatinine (eGFR), separately for individuals with or without DM (n(DM) = 178,691, n(noDM) = 1,296,113). Our genome-wide searches identified (i) seven eGFR loci with significant DM/noDM-difference, (ii) four additional novel loci with suggestive difference and (iii) 28 further novel loci (including CUBN) by allowing for potential difference. GWAS on eGFR among DM individuals identified 2 known and 27 potentially responsible loci for diabetic kidney disease. Gene prioritization highlighted 18 genes that may inform reno-protective drug development. We highlight the existence of DM-only and noDM-only effects, which can inform about the target group, if respective genes are advanced as drug targets. Largely shared effects suggest that most drug interventions to alter eGFR should be effective in DM and noDM.

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