Tuberculosis infection and lung adenocarcinoma: Mendelian randomization and pathway analysis of genome-wide association study data from never-smoking Asian women

结核病感染与肺腺癌：来自从未吸烟的亚洲女性的全基因组关联研究数据的孟德尔随机化和通路分析

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作者：Wong,Jason Y Y,Zhang,Han,Hsiung,Chao A,Shiraishi,Kouya,Yu,Kai,Matsuo,Keitaro,Wong,Maria Pik,Hong,Yun-Chul,Wang,Jiucun,Seow,Wei Jie,Wang,Zhaoming,Song,Minsun,Kim,Hee Nam,Chang,I-Shou,Chatterjee,Nilanjan,Hu,Wei,Wu,Chen,Mitsudomi,Tetsuya,Zheng,Wei,Kim,Jin Hee,Seow,Adeline,Caporaso,Neil E,Shin,Min-Ho,Chung,Lap Ping,An,She-Juan,Wang,Ping,Yang,Yang,Zheng,Hong,Yatabe,Yasushi,Zhang,Xu-Chao,Kim,Young Tae,Cai,Qiuyin,Yin,Zhihua,Kim,Young-Chul,Bassig,Bryan A,Chang,Jiang,Ho,James Chung Man,Ji,Bu-Tian,Daigo,Yataro,Ito,Hidemi,Momozawa,Yukihide,Ashikawa,Kyota,Kamatani,Yoichiro,Honda,Takayuki,Hosgood,H Dean,Sakamoto,Hiromi,Kunitoh,Hideo,Tsuta,Koji,Watanabe,Shun-Ichi,Kubo,Michiaki,Miyagi,Yohei,Nakayama,Haruhiko,Matsumoto,Shingo,Tsuboi,Masahiro,Goto,Koichi,Shi,Jianxin,Song,Lei,Hua,Xing,Takahashi,Atsushi,Goto,Akiteru,Minamiya,Yoshihiro,Shimizu,Kimihiro,Tanaka,Kazumi,Wei,Fusheng,Matsuda,Fumihiko,Su,Jian,Kim,Yeul Hong,Oh,In-Jae,Song,Fengju,Su,Wu-Chou,Chen,Yu-Min,Chang,Gee-Chen,Chen,Kuan-Yu,Huang,Ming-Shyan,Chien,Li-Hsin,Xiang,Yong-Bing,Park,Jae Yong,Kweon,Sun-Seog,Chen,Chien-Jen,Lee,Kyoung-Mu,Blechter,Batel,Li,Haixin,Gao,Yu-Tang,Qian,Biyun,Lu,Daru,Liu,Jianjun,Jeon,Hyo-Sung,Hsiao,Chin-Fu,Sung,Jae Sook,Tsai,Ying-Huang,Jung,Yoo Jin,Guo,Huan,Hu,Zhibin,Wang,Wen-Chang,Chung,Charles C,Burdett,Laurie,Yeager,Meredith,Hutchinson,Amy,Berndt,Sonja I,Wu,Wei,Pang,Herbert,Li,Yuqing,Choi,Jin Eun,Park,Kyong Hwa,Sung,Sook Whan,Liu,Li,Kang,C H,Zhu,Meng,Chen,Chung-Hsing,Yang,Tsung-Ying,Xu,Jun,Guan,Peng,Tan,Wen,Wang,Chih-Liang,Hsin,Michael,Sit,Ko-Yung,Ho,James,Chen,Ying,Choi,Yi Young,Hung,Jen-Yu,Kim,Jun Suk,Yoon,Ho Il,Lin,Chien-Chung,Park,In Kyu,Xu,Ping,Wang,Yuzhuo,He,Qincheng,Perng,Reury-Perng,Chen,Chih-Yi,Vermeulen,Roel,Wu,Junjie,Lim,Wei-Yen,Chen,Kun-Chieh,Li,Yao-Jen,Li,Jihua,Chen,Hongyan,Yu,Chong-Jen,Jin,Li,Chen,Tzu-Yu,Jiang,Shih-Sheng,Liu,Jie,Yamaji,Taiki,Hicks,Belynda,Wyatt,Kathleen,Li,Shengchao A,Dai,Juncheng,Ma,Hongxia,Jin,Guangfu,Song,Bao,Wang,Zhehai,Cheng,Sensen,Li,Xuelian,Ren,Yangwu,Cui,Ping,Iwasaki,Motoki,Shimazu,Taichi,Tsugane,Shoichiro,Zhu,Junjie,Chen,Ying,Yang,Kaiyun,Jiang,Gening,Fei,Ke,Wu,Guoping,Lin,Hsien-Chin,Chen,Hui-Ling,Fang,Yao-Huei,Tsai,Fang-Yu,Hsieh,Wan-Shan,Yu,Jinming,Stevens,Victoria L,Laird-Offringa,Ite A,Marconett,Crystal N,Rieswijk,Linda,Chao,Ann,Yang,Pan-Chyr,Shu,Xiao-Ou,Wu,Tangchun,Wu,Y L,Lin,Dongxin,Chen,Kexin,Zhou,Baosen,Huang,Yun-Chao,Kohno,Takashi,Shen,Hongbing,Chanock,Stephen J,Rothman,Nathaniel,Lan,Qing
期刊：Genomics影响因子：3.000
时间：2020起止号：2020 Mar;112(2):1223-1232
doi：10.1016/j.ygeno.2019.07.008

Abstract

We investigated whether genetic susceptibility to tuberculosis (TB) influences lung adenocarcinoma development among never-smokers using TB genome-wide association study (GWAS) results within the Female Lung Cancer Consortium in Asia. Pathway analysis with the adaptive rank truncated product method was used to assess the association between a TB-related gene-set and lung adenocarcinoma using GWAS data from 5512 lung adenocarcinoma cases and 6277 controls. The gene-set consisted of 31 genes containing known/suggestive associations with genetic variants from previous TB-GWAS. Subsequently, we followed-up with Mendelian Randomization to evaluate the association between TB and lung adenocarcinoma using three genome-wide significant variants from previous TB-GWAS in East Asians. The TB-related gene-set was associated with lung adenocarcinoma (p = 0.016). Additionally, the Mendelian Randomization showed an association between TB and lung adenocarcinoma (OR = 1.31, 95% CI: 1.03, 1.66, p = 0.027). Our findings support TB as a causal risk factor for lung cancer development among never-smoking Asian women.

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