Safety evaluation of an extension of use of the food enzyme glucan 1,4-α-maltohydrolase from a genetically modified Bacillus licheniformis strain NZYM-SD

对源自基因改造的地衣芽孢杆菌NZYM-SD菌株的食品酶葡聚糖1,4-α-麦芽糖水解酶的扩展用途进行安全性评价

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Abstract

The food enzyme glucan 1,4-α-maltohydrolase (4-α-d-glucan α-maltohydrolase, EC 3.2.1.133) is produced with the genetically modified Bacillus licheniformis strain NZYM-SD by Novozymes A/S. The safety evaluation of this food enzyme was evaluated previously and it did not give rise to safety concerns when used in three food manufacturing processes. Subsequently, the applicant has requested to extend its use to include two additional processes. In this assessment, EFSA updated the safety evaluation of this food enzyme when used in a total of five food manufacturing processes. As the food enzyme-total organic solids (TOS) are removed in one process, the dietary exposure to the food enzyme-TOS was estimated for the remaining four food manufacturing processes. It was estimated to be up to 0.676 mg TOS/kg body weight per day in European populations. Based on the new data, the revised dietary exposure and the previous evaluation, the Panel concluded that this food enzyme does not give rise to safety concerns under the revised intended conditions of use.

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