International network of cancer genome projects

国际癌症基因组计划网络

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作者：Hudson,Thomas J,Anderson,Warwick,Artez,Axel,Barker,Anna D,Bell,Cindy,Bernabé,Rosa R,Bhan,M K,Calvo,Fabien,Eerola,Iiro,Gerhard,Daniela S,Guttmacher,Alan,Guyer,Mark,Hemsley,Fiona M,Jennings,Jennifer L,Kerr,David,Klatt,Peter,Kolar,Patrik,Kusada,Jun,Lane,David P,Laplace,Frank,Youyong,Lu,Nettekoven,Gerd,Ozenberger,Brad,Peterson,Jane,Rao,T S,Remacle,Jacques,Schafer,Alan J,Shibata,Tatsuhiro,Stratton,Michael R,Vockley,Joseph G,Watanabe,Koichi,Yang,Huanming,Yuen,Matthew M F,Knoppers,Bartha M,Bobrow,Martin,Cambon-Thomsen,Anne,Dressler,Lynn G,Dyke,Stephanie O M,Joly,Yann,Kato,Kazuto,Kennedy,Karen L,Nicolás,Pilar,Parker,Michael J,Rial-Sebbag,Emmanuelle,Romeo-Casabona,Carlos M,Shaw,Kenna M,Wallace,Susan,Wiesner,Georgia L,Zeps,Nikolajs,Lichter,Peter,Biankin,Andrew V,Chabannon,Christian,Chin,Lynda,Clément,Bruno,de Alava,Enrique,Degos,Françoise,Ferguson,Martin L,Geary,Peter,Hayes,D Neil,Hudson,Thomas J,Johns,Amber L,Kasprzyk,Arek,Nakagawa,Hidewaki,Penny,Robert,Piris,Miguel A,Sarin,Rajiv,Scarpa,Aldo,Shibata,Tatsuhiro,van de Vijver,Marc,Futreal,P Andrew,Aburatani,Hiroyuki,Bayés,Mónica,Botwell,David D L,Campbell,Peter J,Estivill,Xavier,Gerhard,Daniela S,Grimmond,Sean M,Gut,Ivo,Hirst,Martin,López-Otín,Carlos,Majumder,Partha,Marra,Marco,McPherson,John D,Nakagawa,Hidewaki,Ning,Zemin,Puente,Xose S,Ruan,Yijun,Shibata,Tatsuhiro,Stratton,Michael R,Stunnenberg,Hendrik G,Swerdlow,Harold,Velculescu,Victor E,Wilson,Richard K,Xue,Hong H,Yang,Liu,Spellman,Paul T,Bader,Gary D,Boutros,Paul C,Campbell,Peter J,Flicek,Paul,Getz,Gad,Guigó,Roderic,Guo,Guangwu,Haussler,David,Heath,Simon,Hubbard,Tim J,Jiang,Tao,Jones,Steven M,Li,Qibin,López-Bigas,Nuria,Luo,Ruibang,Muthuswamy,Lakshmi,Ouellette,B F Francis,Pearson,John V,Puente,Xose S,Quesada,Victor,Raphael,Benjamin J,Sander,Chris,Shibata,Tatsuhiro,Speed,Terence P,Stein,Lincoln D,Stuart,Joshua M,Teague,Jon W,Totoki,Yasushi,Tsunoda,Tatsuhiko,Valencia,Alfonso,Wheeler,David A,Wu,Honglong,Zhao,Shancen,Zhou,Guangyu,Stein,Lincoln D,Guigó,Roderic,Hubbard,Tim J,Joly,Yann,Jones,Steven M,Kasprzyk,Arek,Lathrop,Mark,López-Bigas,Nuria,Ouellette,B F Francis,Spellman,Paul T,Teague,Jon W,Thomas,Gilles,Valencia,Alfonso,Yoshida,Teruhiko,Kennedy,Karen L,Axton,Myles,Dyke,Stephanie O M,Futreal,P Andrew,Gerhard,Daniela S,Gunter,Chris,Guyer,Mark,Hudson,Thomas J,McPherson,John D,Miller,Linda J,Ozenberger,Brad,Shaw,Kenna M,Kasprzyk,Arek,Stein,Lincoln D,Zhang,Junjun,Haider,Syed A,Wang,Jianxin,Yung,Christina K,Cros,Anthony,Liang,Yong,Gnaneshan,Saravanamuttu,Guberman,Jonathan,Hsu,Jack,Bobrow,Martin,Chalmers,Don R C,Hasel,Karl W,Joly,Yann,Kaan,Terry S H,Kennedy,Karen L,Knoppers,Bartha M,Lowrance,William W,Masui,Tohru,Nicolás,Pilar,Rial-Sebbag,Emmanuelle,Rodriguez,Laura Lyman,Vergely,Catherine,Yoshida,Teruhiko,Grimmond,Sean M,Biankin,Andrew V,Bowtell,David D L,Cloonan,Nicole,deFazio,Anna,Eshleman,James R,Etemadmoghadam,Dariush,Gardiner,Brooke B,Kench,James G,Scarpa,Aldo,Sutherland,Robert L,Tempero,Margaret A,Waddell,Nicola J,Wilson,Peter J,McPherson,John D,Gallinger,Steve,Tsao,Ming-Sound,Shaw,Patricia A,Petersen,Gloria M,Mukhopadhyay,Debabrata,Chin,Lynda,DePinho,Ronald A,Thayer,Sarah,Muthuswamy,Lakshmi,Shazand,Kamran,Beck,Timothy,Sam,Michelle,Timms,Lee,Ballin,Vanessa,Lu,Youyong,Ji,Jiafu,Zhang,Xiuqing,Chen,Feng,Hu,Xueda,Zhou,Guangyu,Yang,Qi,Tian,Geng,Zhang,Lianhai,Xing,Xiaofang,Li,Xianghong,Zhu,Zhenggang,Yu,Yingyan,Yu,Jun,Yang,Huanming,Lathrop,Mark,Tost,Jörg,Brennan,Paul,Holcatova,Ivana,Zaridze,David,Brazma,Alvis,Egevard,Lars,Prokhortchouk,Egor,Banks,Rosamonde Elizabeth,Uhlén,Mathias,Cambon-Thomsen,Anne,Viksna,Juris,Ponten,Fredrik,Skryabin,Konstantin,Stratton,Michael R,Futreal,P Andrew,Birney,Ewan,Borg,Ake,Børresen-Dale,Anne-Lise,Caldas,Carlos,Foekens,John A,Martin,Sancha,Reis-Filho,Jorge S,Richardson,Andrea L,Sotiriou,Christos,Stunnenberg,Hendrik G,Thoms,Giles,van de Vijver,Marc,van't Veer,Laura,Calvo,Fabien,Birnbaum,Daniel,Blanche,Hélène,Boucher,Pascal,Boyault,Sandrine,Chabannon,Christian,Gut,Ivo,Masson-Jacquemier,Jocelyne D,Lathrop,Mark,Pauporté,Iris,Pivot,Xavier,Vincent-Salomon,Anne,Tabone,Eric,Theillet,Charles,Thomas,Gilles,Tost,Jörg,Treilleux,Isabelle,Calvo,Fabien,Bioulac-Sage,Paulette,Clément,Bruno,Decaens,Thomas,Degos,Françoise,Franco,Dominique,Gut,Ivo,Gut,Marta,Heath,Simon,Lathrop,Mark,Samuel,Didier,Thomas,Gilles,Zucman-Rossi,Jessica,Lichter,Peter,Eils,Roland,Brors,Benedikt,Korbel,Jan O,Korshunov,Andrey,Landgraf,Pablo,Lehrach,Hans,Pfister,Stefan,Radlwimmer,Bernhard,Reifenberger,Guido,Taylor,Michael D,von Kalle,Christof,Majumder,Partha P,Sarin,Rajiv,Rao,T S,Bhan,M K,Scarpa,Aldo,Pederzoli,Paolo,Lawlor,Rita A,Delledonne,Massimo,Bardelli,Alberto,Biankin,Andrew V,Grimmond,Sean M,Gress,Thomas,Klimstra,David,Zamboni,Giuseppe,Shibata,Tatsuhiro,Nakamura,Yusuke,Nakagawa,Hidewaki,Kusada,Jun,Tsunoda,Tatsuhiko,Miyano,Satoru,Aburatani,Hiroyuki,Kato,Kazuto,Fujimoto,Akihiro,Yoshida,Teruhiko,Campo,Elias,López-Otín,Carlos,Estivill,Xavier,Guigó,Roderic,de Sanjosé,Silvia,Piris,Miguel A,Montserrat,Emili,González-Díaz,Marcos,Puente,Xose S,Jares,Pedro,Valencia,Alfonso,Himmelbauer,Heinz,Quesada,Victor,Bea,Silvia,Stratton,Michael R,Futreal,P Andrew,Campbell,Peter J,Vincent-Salomon,Anne,Richardson,Andrea L,Reis-Filho,Jorge S,van de Vijver,Marc,Thomas,Gilles,Masson-Jacquemier,Jocelyne D,Aparicio,Samuel,Borg,Ake,Børresen-Dale,Anne-Lise,Caldas,Carlos,Foekens,John A,Stunnenberg,Hendrik G,van't Veer,Laura,Easton,Douglas F,Spellman,Paul T,Martin,Sancha,Barker,Anna D,Chin,Lynda,Collins,Francis S,Compton,Carolyn C,Ferguson,Martin L,Gerhard,Daniela S,Getz,Gad,Gunter,Chris,Guttmacher,Alan,Guyer,Mark,Hayes,D Neil,Lander,Eric S,Ozenberger,Brad,Penny,Robert,Peterson,Jane,Sander,Chris,Shaw,Kenna M,Speed,Terence P,Spellman,Paul T,Vockley,Joseph G,Wheeler,David A,Wilson,Richard K,Hudson,Thomas J,Chin,Lynda,Knoppers,Bartha M,Lander,Eric S,Lichter,Peter,Stein,Lincoln D,Stratton,Michael R,Anderson,Warwick,Barker,Anna D,Bell,Cindy,Bobrow,Martin,Burke,Wylie,Collins,Francis S,Compton,Carolyn C,DePinho,Ronald A,Easton,Douglas F,Futreal,P Andrew,Gerhard,Daniela S,Green,Anthony R,Guyer,Mark,Hamilton,Stanley R,Hubbard,Tim J,Kallioniemi,Olli P,Kennedy,Karen L,Ley,Timothy J,Liu,Edison T,Lu,Youyong,Majumder,Partha,Marra,Marco,Ozenberger,Brad,Peterson,Jane,Schafer,Alan J,Spellman,Paul T,Stunnenberg,Hendrik G,Wainwright,Brandon J,Wilson,Richard K,Yang,Huanming
期刊：Nature影响因子：48.500
时间：2010起止号：2010 Apr 15;464(7291):993-8
doi：10.1038/nature08987研究方向： 肿瘤

Abstract

The International Cancer Genome Consortium (ICGC) was launched to coordinate large-scale cancer genome studies in tumours from 50 different cancer types and/or subtypes that are of clinical and societal importance across the globe. Systematic studies of more than 25,000 cancer genomes at the genomic, epigenomic and transcriptomic levels will reveal the repertoire of oncogenic mutations, uncover traces of the mutagenic influences, define clinically relevant subtypes for prognosis and therapeutic management, and enable the development of new cancer therapies.

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