Studies Exploring the Interaction of the Organophosphorus Compound Paraoxon with Fullerenes

研究有机磷化合物对氧磷与富勒烯的相互作用

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Abstract

In vitro experiments previously published demonstrated the ability of fullerenes to decrease the capability of organophosphorus (OP) compounds to inhibit acetylcholinesterase. Experiments described herein demonstrate molecular level affinity interactions between fullerenes and the OP test compound paraoxon with NMR spectroscopy. The calculated binding constant of 19 M(-1) indicates that this binding was not covalent.

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