Abstract
This integrated multi-omics resource delineates the molecular and phenotypic trajectories underlying male morphotype differentiation (Blue Claw [BC], Orange Claw [OC], Small Male [SM]) in Macrobrachium rosenbergii during determinative developmental stages (100, 110, and 120 days post-stocking). The dataset comprises hemolymph metabolomes, gut microbiota 16S rRNA sequencing data and quantitative morphological trait data, thereby establishing a holistic framework capturing metabolic flux alterations, microbial community structure and phenotypic manifestations throughout morphotype specification. The synergistic integration of these layers provides support for the identification of heritable biomarkers linked to commercially advantageous morphotypes and reveals the important role of host-microbiota interactions in phenotypic divergence. All raw and processed omics data are deposited in NCBI SRA and Metabolights.