Mature CD8(+) T-cell clonal expansion in the oral cavity and digestive tract: a severe lymphoid malignancy that mimics Crohn's disease

In patients with atypical Crohn's disease features, including severe oral ulcerations and resistance to standard treatment, the possibility of a mature clonal CD8(+) T-cell lymphoproliferative disorder should be investigated. Clinicians should be aware of this differential diagnosis because CD8(+) T-cell lymphoma prognosis can be remarkably favorable upon oral treatment with cyclophosphamide.