Carbocyclic pyrimidine nucleosides as inhibitors of S-adenosylhomocysteine hydrolase
碳环嘧啶核苷作为 S-腺苷同型半胱氨酸水解酶的抑制剂
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作者：Sylvester L Mosley, Brian A Bakke, Joshua M Sadler, Naresh K Sunkara, Kathleen M Dorgan, Zhaohui Sunny Zhou, Katherine L Seley-Radtke
Abstract
The design, synthesis, and unexpected inhibitory activity against S-adenosyl-homocysteine (SAH) hydrolase (SAHase, EC 3.3.1.1) for a series of truncated carbocyclic pyrimidine nucleoside analogues is presented. Of the four nucleosides obtained, 10 was found to be active with a Ki value of 5.0 microM against SAHase.
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