日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

CCNE1 amplification is synthetic lethal with PKMYT1 kinase inhibition

CCNE1 扩增与 PKMYT1 激酶抑制一起具有合成致死性

David Gallo #, Jordan T F Young #, Jimmy Fourtounis #, Giovanni Martino, Alejandro Álvarez-Quilón, Cynthia Bernier, Nicole M Duffy, Robert Papp, Anne Roulston, Rino Stocco, Janek Szychowski, Artur Veloso, Hunain Alam, Prasamit S Baruah, Alexanne Bonneau Fortin, Julian Bowlan, Natasha Chaudhary, Jess

RP-3500: A Novel, Potent, and Selective ATR Inhibitor that is Effective in Preclinical Models as a Monotherapy and in Combination with PARP Inhibitors

RP-3500:一种新型、强效且选择性的 ATR 抑制剂,在临床前模型中作为单一疗法和与 PARP 抑制剂联合使用均有效

Anne Roulston, Michal Zimmermann, Robert Papp, Alexander Skeldon, Charles Pellerin, Émilie Dumas-Bérube, Valerie Dumais, Stéphane Dorich, Lee D Fader, Sara Fournier, Li Li, Marie-Eve Leclaire, Shou Yun Yin, Amandine Chefson, Hunain Alam, William Yang, Chloe Fugère-Desjardins, Sabrina Vignini-Hammond

KMT2D Deficiency Impairs Super-Enhancers to Confer a Glycolytic Vulnerability in Lung Cancer

KMT2D缺陷会损害超级增强子,从而导致肺癌细胞糖酵解脆弱性。

Hunain Alam ,Ming Tang ,Mayinuer Maitituoheti ,Shilpa S Dhar ,Manish Kumar ,Chae Young Han ,Chandrashekar R Ambati ,Samir B Amin ,Bingnan Gu ,Tsai-Yu Chen ,Yu-Hsi Lin ,Jichao Chen ,Florian L Muller ,Nagireddy Putluri ,Elsa R Flores ,Francesco J DeMayo ,Laura Baseler ,Kunal Rai ,Min Gyu Lee

Enhancer Reprogramming Confers Dependence on Glycolysis and IGF Signaling in KMT2D Mutant Melanoma

增强子重编程使 KMT2D 突变黑色素瘤依赖于糖酵解和 IGF 信号传导

Mayinuer Maitituoheti, Emily Z Keung, Ming Tang, Liang Yan, Hunain Alam, Guangchun Han, Anand K Singh, Ayush T Raman, Christopher Terranova, Sharmistha Sarkar, Elias Orouji, Samir B Amin, Sneha Sharma, Maura Williams, Neha S Samant, Mayura Dhamdhere, Norman Zheng, Tara Shah, Amiksha Shah, Jacob B Ax

MLL4 Is Required to Maintain Broad H3K4me3 Peaks and Super-Enhancers at Tumor Suppressor Genes

MLL4 是维持肿瘤抑制基因中宽 H3K4me3 峰和超增强子所必需的

Shilpa S Dhar, Dongyu Zhao, Tao Lin, Bingnan Gu, Khusboo Pal, Sarah J Wu, Hunain Alam, Jie Lv, Kyuson Yun, Vidya Gopalakrishnan, Elsa R Flores, Paul A Northcott, Veena Rajaram, Wei Li, Ali Shilatifard, Roy V Sillitoe, Kaifu Chen, Min Gyu Lee

HP1γ Promotes Lung Adenocarcinoma by Downregulating the Transcription-Repressive Regulators NCOR2 and ZBTB7A

HP1γ通过下调转录抑制调节因子NCOR2和ZBTB7A促进肺腺癌

Hunain Alam, Na Li, Shilpa S Dhar, Sarah J Wu, Jie Lv, Kaifu Chen, Elsa R Flores, Laura Baseler, Min Gyu Lee

Transcriptional repression of histone deacetylase 3 by the histone demethylase KDM2A is coupled to tumorigenicity of lung cancer cells

组蛋白去甲基化酶 KDM2A 对组蛋白去乙酰化酶 3 的转录抑制与肺癌细胞的致瘤性有关

Shilpa S Dhar, Hunain Alam, Na Li, Klaus W Wagner, Jimyung Chung, Yeo Won Ahn, Min Gyu Lee

KDM2A promotes lung tumorigenesis by epigenetically enhancing ERK1/2 signaling

KDM2A 通过表观遗传增强 ERK1/2 信号传导促进肺肿瘤发生

Klaus W Wagner, Hunain Alam, Shilpa S Dhar, Uma Giri, Na Li, Yongkun Wei, Dipak Giri, Tina Cascone, Jae-Hwan Kim, Yuanqing Ye, Asha S Multani, Chia-Hsin Chan, Baruch Erez, Babita Saigal, Jimyung Chung, Hui-Kuan Lin, Xifeng Wu, Mien-Chie Hung, John V Heymach, Min Gyu Lee

Understanding the role of keratins 8 and 18 in neoplastic potential of breast cancer derived cell lines

了解角蛋白 8 和 18 在乳腺癌衍生细胞系肿瘤潜能中的作用

Sapna V Iyer, Prerana P Dange, Hunain Alam, Sharada S Sawant, Arvind D Ingle, Anita M Borges, Neelam V Shirsat, Sorab N Dalal, Milind M Vaidya