日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Changes in immune cell populations following KappaMab, lenalidomide and low-dose dexamethasone treatment in multiple myeloma

KappaMab、来那度胺和低剂量地塞米松治疗多发性骨髓瘤后免疫细胞群的变化

Samuel E Norton, Tiffany Khong, Malarmathy Ramachandran, Andrew J Highton, Kirsten A Ward-Hartstonge, Jake Shortt, Andrew Spencer, Roslyn A Kemp

A phase 1 clinical trial of the repurposable acetyllysine mimetic, n-methyl-2-pyrrolidone (NMP), in relapsed or refractory multiple myeloma

一项针对复发或难治性多发性骨髓瘤的可重复利用乙酰赖氨酸类似物N-甲基-2-吡咯烷酮(NMP)的I期临床试验

Jake Shortt; Galettis, Peter; Cheah, Chan Y; Davis, Joanne; Ludford-Menting, Mandy; Link, Emma K; Martin, Jennifer H; Koldej, Rachel; Ritchie, David

Rationally designed chimeric PI3K-BET bromodomain inhibitors elicit curative responses in MYC-driven lymphoma

合理设计的嵌合 PI3K-BET 溴结构域抑制剂可在 MYC 驱动的淋巴瘤中引发治愈反应

Danielle H Oh #, Xiao Ma #, Simon J Hogg, Jackson He, Conor Kearney, Daniella Brasacchio, Olivia Susanto, Belinda Maher, Ian G Jennings, Andrea Newbold, Peter Fraser, Emily Gruber, Lev M Kats, Gareth P Gregory, Ricky W Johnstone #, Philip E Thompson #, Jake Shortt #

Inhibition of mutant IDH1 promotes cycling of acute myeloid leukemia stem cells

抑制突变IDH1可促进急性髓系白血病干细胞循环

Emily Gruber, Joan So, Alexander C Lewis, Rheana Franich, Rachel Cole, Luciano G Martelotto, Amy J Rogers, Eva Vidacs, Peter Fraser, Kym Stanley, Lisa Jones, Anna Trigos, Niko Thio, Jason Li, Brandon Nicolay, Scott Daigle, Adriana E Tron, Marc L Hyer, Jake Shortt, Ricky W Johnstone, Lev M Kats

Distinct modulation of IFNγ-induced transcription by BET bromodomain and catalytic P300/CBP inhibition in breast cancer

乳腺癌中 BET 溴结构域和催化 P300/CBP 抑制对 IFNγ 诱导转录的不同调节

Simon J Hogg #, Olga Motorna #, Conor J Kearney, Emily B Derrick, Imran G House, Izabela Todorovski, Madison J Kelly, Magnus Zethoven, Kenneth D Bromberg, Albert Lai, Paul A Beavis, Jake Shortt, Ricky W Johnstone #, Stephin J Vervoort #

Targeting histone acetylation dynamics and oncogenic transcription by catalytic P300/CBP inhibition

通过抑制催化性P300/CBP来靶向组蛋白乙酰化动态和致癌转录

Simon J Hogg ,Olga Motorna ,Leonie A Cluse ,Timothy M Johanson ,Hannah D Coughlan ,Ramya Raviram ,Robert M Myers ,Matteo Costacurta ,Izabela Todorovski ,Lizzy Pijpers ,Stefan Bjelosevic ,Tobias Williams ,Shannon N Huskins ,Conor J Kearney ,Jennifer R Devlin ,Zheng Fan ,Jafar S Jabbari ,Ben P Martin ,Mohamed Fareh ,Madison J Kelly ,Daphné Dupéré-Richer ,Jarrod J Sandow ,Breon Feran ,Deborah Knight ,Tiffany Khong ,Andrew Spencer ,Simon J Harrison ,Gareth Gregory ,Vihandha O Wickramasinghe ,Andrew I Webb ,Phillippa C Taberlay ,Kenneth D Bromberg ,Albert Lai ,Anthony T Papenfuss ,Gordon K Smyth ,Rhys S Allan ,Jonathan D Licht ,Dan A Landau ,Omar Abdel-Wahab ,Jake Shortt ,Stephin J Vervoort ,Ricky W Johnstone

A novel CDK9 inhibitor increases the efficacy of venetoclax (ABT-199) in multiple models of hematologic malignancies

新型 CDK9 抑制剂可增强维奈克拉 (ABT-199) 在多种血液系统恶性肿瘤模型中的疗效

Darren C Phillips, Sha Jin, Gareth P Gregory, Qi Zhang, John Xue, Xiaoxian Zhao, Jun Chen, Yunsong Tong, Haichao Zhang, Morey Smith, Stephen K Tahir, Rick F Clark, Thomas D Penning, Jennifer R Devlin, Jake Shortt, Eric D Hsi, Daniel H Albert, Marina Konopleva, Ricky W Johnstone, Joel D Leverson, And

Genomic characterisation of Eμ-Myc mouse lymphomas identifies Bcor as a Myc co-operative tumour-suppressor gene

Eμ-Myc 小鼠淋巴瘤的基因组表征表明 Bcor 是一种 Myc 协同肿瘤抑制基因

Marcus Lefebure, Richard W Tothill, Elizabeth Kruse, Edwin D Hawkins, Jake Shortt, Geoffrey M Matthews, Gareth P Gregory, Benjamin P Martin, Madison J Kelly, Izabela Todorovski, Maria A Doyle, Richard Lupat, Jason Li, Jan Schroeder, Meaghan Wall, Stuart Craig, Gretchen Poortinga, Don Cameron, Megan

BET-Bromodomain Inhibitors Engage the Host Immune System and Regulate Expression of the Immune Checkpoint Ligand PD-L1

BET-溴结构域抑制剂参与宿主免疫系统并调节免疫检查点配体 PD-L1 的表达

Simon J Hogg, Stephin J Vervoort, Sumit Deswal, Christopher J Ott, Jason Li, Leonie A Cluse, Paul A Beavis, Phillip K Darcy, Benjamin P Martin, Andrew Spencer, Anna K Traunbauer, Irina Sadovnik, Karin Bauer, Peter Valent, James E Bradner, Johannes Zuber, Jake Shortt, Ricky W Johnstone

The CDK9 Inhibitor Dinaciclib Exerts Potent Apoptotic and Antitumor Effects in Preclinical Models of MLL-Rearranged Acute Myeloid Leukemia

CDK9 抑制剂 Dinaciclib 在 MLL 重排急性髓系白血病的临床前模型中发挥强大的凋亡和抗肿瘤作用

Adele Baker, Gareth P Gregory, Inge Verbrugge, Lev Kats, Joshua J Hilton, Eva Vidacs, Erwin M Lee, Richard B Lock, Johannes Zuber, Jake Shortt, Ricky W Johnstone