日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

MTA-Cooperative PRMT5 Inhibitors: Mechanism Switching Through Structure-Based Design

MTA协同PRMT5抑制剂:基于结构的机制转换设计

Kevin M Cottrell,Douglas A Whittington,Kimberly J Briggs,Haris Jahic,Janid A Ali,Alvaro J Amor,Deepali Gotur,Matthew R Tonini,Wenhai Zhang,Alan Huang,John P Maxwell

LIG1 Is a Synthetic Lethal Target in BRCA1 Mutant Cancers.

LIG1 是 BRCA1 突变癌症中的合成致死靶点

Martires Lauren Catherine M, Ahronian Leanne G, Pratt Charlotte B, Das Nikitha M, Zhang Xiaobin, Whittington Douglas A, Zhang Hongxiang, Shen Binzhang, Come Jon, McCarren Patrick, Liu Mu-Sen, Min Chengyin, Feng Tianshu, Jahic Haris, Ali Janid A, Aird Daniel R, Li Fang, Andersen Jannik N, Huang Alan, Mallender William D, Nicholson Hilary E

The USP1 Inhibitor KSQ-4279 Overcomes PARP Inhibitor Resistance in Homologous Recombination-Deficient Tumors

USP1 抑制剂 KSQ-4279 克服了同源重组缺陷肿瘤中的 PARP 抑制剂耐药性

Louise Cadzow, Jehrod Brenneman, Erica Tobin, Pamela Sullivan, Sumeet Nayak, Janid A Ali, Sol Shenker, Jim Griffith, Michael McGuire, Paula Grasberger, Yuji Mishina, Morgan Murray, Anne E Dodson, Hugh Gannon, Elsa Krall, Jeff Hixon, Edmond Chipumuro, Kerstin Sinkevicius, Prafulla C Gokhale, Suthakar

Discovery of TNG908: A Selective, Brain Penetrant, MTA-Cooperative PRMT5 Inhibitor That Is Synthetically Lethal with MTAP-Deleted Cancers

TNG908 的发现:一种选择性强、可穿透血脑屏障、与 MTA 协同作用的 PRMT5 抑制剂,对 MTAP 缺失的癌症具有合成致死作用

Kevin M Cottrell,Kimberly J Briggs,Douglas A Whittington,Haris Jahic,Janid A Ali,Charles B Davis,Shanzhong Gong,Deepali Gotur,Lina Gu,Patrick McCarren,Matthew R Tonini,Alice Tsai,Erik W Wilker,Hongling Yuan,Minjie Zhang,Wenhai Zhang,Alan Huang,John P Maxwell

Discovery of a Selective Phosphoinositide-3-Kinase (PI3K)-γ Inhibitor (IPI-549) as an Immuno-Oncology Clinical Candidate

发现一种选择性磷脂酰肌醇-3-激酶 (PI3K)-γ 抑制剂 (IPI-549) 作为免疫肿瘤学临床候选药物

Evans, Catherine A; Liu, Tao; Lescarbeau, André; Nair, Somarajan J; Grenier, Louis; Pradeilles, Johan A; Glenadel, Quentin; Tibbitts, Thomas; Rowley, Ann M; DiNitto, Jonathan P; Brophy, Erin E; O'Hearn, Erin L; Ali, Janid A; Winkler, David G; Goldstein, Stanley I; O'Hearn, Patrick; Martin, Christian M; Hoyt, Jennifer G; Soglia, John R; Cheung, Culver; Pink, Melissa M; Proctor, Jennifer L; Palombella, Vito J; Tremblay, Martin R; Castro, Alfredo C

HSP90 inhibition enhances antimitotic drug-induced mitotic arrest and cell death in preclinical models of non-small cell lung cancer

在非小细胞肺癌临床前模型中,HSP90 抑制可增强抗有丝分裂药物诱导的有丝分裂停滞和细胞死亡

Brenda C O'Connell, Katie O'Callaghan, Bonnie Tillotson, Mark Douglas, Nafeeza Hafeez, Kip A West, Howard Stern, Janid A Ali, Paul Changelian, Christian C Fritz, Vito J Palombella, Karen McGovern, Jeffery L Kutok

PI3K-δ and PI3K-γ inhibition by IPI-145 abrogates immune responses and suppresses activity in autoimmune and inflammatory disease models

IPI-145 抑制 PI3K-δ 和 PI3K-γ 可消除免疫反应并抑制自身免疫和炎症疾病模型中的活性

David G Winkler, Kerrie L Faia, Jonathan P DiNitto, Janid A Ali, Kerry F White, Erin E Brophy, Melissa M Pink, Jennifer L Proctor, Jennifer Lussier, Christian M Martin, Jennifer G Hoyt, Bonnie Tillotson, Erin L Murphy, Alice R Lim, Brian D Thomas, John R Macdougall, Pingda Ren, Yi Liu, Lian-Sheng Li