日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Intradermal delivery of lipophilic siRNAs enables prolonged skin retention and sustained gene silencing in a porcine model.

在猪模型中,皮内注射亲脂性siRNA可实现皮肤长期滞留和持续基因沉默。

Fakih Hassan H, Zain Ui Abideen Mohammad, Rachid Mohamad Omar, Gross Katherine Y, Ormsby Thomas J R, Ross Vella M, Gagnon Rosemary, Dahlke Christopher, Furgal Raymond C, Lochmann Clemens, Summers Ashley, Sleiman Hanadi F, Fürst Sylvia M, Jackson Shanté N, Gordilho Juliana O, Bouix-Peter Claire, Portal Thibaud, Tang Qi, Harris John E, Khvorova Anastasia, Blanchard Carine, Alterman Julia F

Therapeutic delivery of albumin-binding siRNA targeting IRS2 to diverse cell types reduces mammary tumor growth.

将靶向 IRS2 的白蛋白结合 siRNA 治疗性递送至多种细胞类型可减少乳腺肿瘤的生长。

Tocheny Claire E, Buchwald Julianna E, Dahlke Christopher D, Fakih Hassan H, Morgan Jennifer S, Summers Ashley, Silva Christi A, Jackson Samuel O, Lee Ji-Sun, Card Michael-Anthony, Echeverria Dimas, Peterson Cornelia, Mercurio Arthur M, Khvorova Anastasia, Shaw Leslie M

An siRNA targeting S6k1 identifies photoreceptor phospholipid metabolism as a contributor to lipid buildup in age-related macular degeneration.

针对 S6k1 的 siRNA 发现光感受器磷脂代谢是导致年龄相关性黄斑变性中脂质积累的因素之一。

Cheng Shun-Yun, Giguere Delaney, Kim San, Seddon Johanna M, Caiazzi Jillian, Gross Katherine, McHugh Nicholas, Echeverria Dimas, Alterman Julia F, Gray-Edwards Heather, Benatti Hector Ribeiro, Renner Lauren, Woolard Hannah, Stoddard Jonathan, McGill Trevor J, Neuringer Martha, Brush Richard S, Agbaga Martin-Paul, Khvorova Anastasia, Punzo Claudio

Divalent siRNA for prion disease.

用于朊病毒病的二价siRNA。

Gentile Juliana E, Corridon Taylor L, Serack Fiona E, Echeverria Dimas, Kennedy Zachary C, Gallant-Behm Corrie L, Hassler Matthew R, Kinberger Garth A, Kelemen Margaret N, Kamath Nikita G, Lian Yuan, Gross Katherine Y, Miller Rachael, DeSouza-Lenz Kendrick, Howard Michael, Guzman Kenia, Chan Nathan, Laversenne Vanessa, Curtis Daniel T, Fettes Kevin, Lemaitre Marc, Jackson Aimee L, Yamada Ken, Alterman Julia F, Coffey Alissa A, Minikel Eric Vallabh, Khvorova Anastasia, Vallabh Sonia M

Suppression of Huntington's Disease Somatic Instability by Transcriptional Repression and Direct CAG Repeat Binding.

通过转录抑制和直接 CAG 重复序列结合抑制亨廷顿病体细胞不稳定性。

Mathews Ella W, Coffey Sydney R, Gärtner Annette, Belgrad Jillian, Bragg Robert M, O'Reilly Daniel, Cantle Jeffrey P, McHugh Cassandra, Summers Ashley, Fentz Joachim, Schwagarus Tom, Cornelius Antje, Lingos Ioannis, Burch Zoe, Kovalenko Marina, Andrew Marissa A, Bennett C Frank, Kordasiewicz Holly B, Marchionini Deanna M, Wilkinson Hilary, Vogt Thomas F, Beuzer Paolo, Pinto Ricardo M, Khvorova Anastasia, Howland David, Wheeler Vanessa C, Carroll Jeffrey B

Potent and durable gene modulation in heart and muscle with chemically defined lipophilic siRNAs

利用化学成分明确的亲脂性siRNA在心脏和肌肉中实现高效持久的基因调控

Fakih, Hassan H; Lochmann, Clemens; Gagnon, Rosemary; Summers, Ashley; Caiazzi, Jillian; Buchwald, Julianna E; Tang, Qi; Maru, Bruktawit; Hildebrand, Samuel R; Abideen, Mohammad Zain U I; Furgal, Raymond C; Gross, Katherine Y; Yang, Yeon-Suk; Cooper, David; Monopoli, Kathryn R; Echeverria, Dimas; Shim, Jae-Hyuck; Yamada, Ken; Alterman, Julia F; Khvorova, Anastasia

Systematic analysis of siRNA and mRNA features impacting fully chemically modified siRNA efficacy.

对影响完全化学修饰的siRNA功效的siRNA和mRNA特征进行系统分析

Davis Sarah M, Hildebrand Samuel, MacMillan Hannah J, Monopoli Kathryn R, Buchwald Julianna, Sousa Jacquelyn, Cooper David, Ly Socheata, Echeverria Dimas, McHugh Nicholas, Ferguson Chantal, Coles Andrew, Hariharan Vignesh N, O'Reilly Daniel, Tang Qi, Furgal Raymond, Yamada Ken, Alterman Julia F, Gilbert James W, Knox Emily, Pineda Yamilett, Weston Caitlyn N, Baer Christina E, Pai Athma A, Khvorova Anastasia

RNAi-mediated silencing of SOD1 profoundly extends survival and functional outcomes in ALS mice

RNAi介导的SOD1基因沉默显著延长了ALS小鼠的生存期并改善了其功能预后。

Alexandra Weiss ,James W Gilbert ,Iris Valeria Rivera Flores ,Jillian Belgrad ,Chantal Ferguson ,Elif O Dogan ,Nicholas Wightman ,Kit Mocarski ,Dimas Echeverria ,Ashley L Harkins ,Ashley Summers ,Brianna Bramato ,Nicholas McHugh ,Raymond Furgal ,Nozomi Yamada ,David Cooper ,Kathryn Monopoli ,Bruno M D C Godinho ,Matthew R Hassler ,Ken Yamada ,Paul Greer ,Nils Henninger ,Robert H Brown Jr ,Anastasia Khvorova

Similar, but not the same: multiomics comparison of human valve interstitial cells and osteoblast osteogenic differentiation expanded with an estimation of data-dependent and data-independent PASEF proteomics

相似但不相同:人类瓣膜间质细胞和成骨细胞成骨分化的多组学比较扩展,并估计了数据依赖和数据独立的 PASEF 蛋白质组学

Arseniy Lobov, Polina Kuchur, Nadezhda Boyarskaya, Daria Perepletchikova, Ivan Taraskin, Andrei Ivashkin, Daria Kostina, Irina Khvorova, Vladimir Uspensky, Egor Repkin, Evgeny Denisov, Tatiana Gerashchenko, Rashid Tikhilov, Svetlana Bozhkova, Vitaly Karelkin, Chunli Wang, Kang Xu, Anna Malashicheva

Endothelial-mesenchymal crosstalk drives osteogenic differentiation of human osteoblasts through Notch signaling

内皮-间质细胞相互作用通过Notch信号通路驱动人类成骨细胞的成骨分化

Perepletchikova, Daria; Kuchur, Polina; Basovich, Liubov; Khvorova, Irina; Lobov, Arseniy; Azarkina, Kseniia; Aksenov, Nikolay; Bozhkova, Svetlana; Karelkin, Vitaliy; Malashicheva, Anna