Lamb Jeffrey相关文献与解析，生知库 | 链接生命科学的每一步

Soma Dash, Maureen C Lamb, Jeffrey J Lange, Mary C McKinney, Dai Tsuchiya, Fengli Guo, Xia Zhao, Timothy J Corbin, MaryEllen Kirkman, Kym Delventhal, Emma L Moore, Sean McKinney, Rita Shiang, Paul A Trainor

信号转导

Goat

IgG Fc

发表日期：2023

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Key Parameters of Tumor Epitope Immunogenicity Revealed Through a Consortium Approach Improve Neoantigen Prediction

通过联合研究方法揭示肿瘤表位免疫原性的关键参数，从而改进新抗原预测

期刊:Cell

影响因子:45.5

doi:10.1016/j.cell.2020.09.015

Daniel K Wells ，Marit M van Buuren ，Kristen K Dang ，Vanessa M Hubbard-Lucey ，Kathleen C F Sheehan ，Katie M Campbell ，Andrew Lamb ，Jeffrey P Ward ，John Sidney ，Ana B Blazquez ，Andrew J Rech ，Jesse M Zaretsky ，Begonya Comin-Anduix ，Alphonsus H C Ng ，William Chour ，Thomas V Yu ，Hira Rizvi ，Jia M Chen ，Patrice Manning ，Gabriela M Steiner ，Xengie C Doan ，Justin Guinney ，Adam Kolom ，Cheryl Selinsky ，Antoni Ribas ，Matthew D Hellmann ，Nir Hacohen ，Alessandro Sette ，James R Heath ，Nina Bhardwaj ，Fred Ramsdell ，Robert D Schreiber ，Ton N Schumacher ，Pia Kvistborg ，Nadine A Defranoux

Neutrophil L-Plastin Controls Ocular Paucibacteriality and Susceptibility to Keratitis.

中性粒细胞 L-Plastin 控制眼部细菌稀少性和角膜炎易感性

期刊:Frontiers in Immunology

影响因子:5.9

doi:10.3389/fimmu.2020.00547

Lu Xiaoxiao, Kugadas Abirami, Smith-Page Kirsten, Lamb Jeffrey, Lin Tiffany, Ru Yusha, Morley Sharon Celeste, Fichorova Raina, Mittal Sharad K, Chauhan Sunil K, Littleton Sejiro, Saban Daniel, Gadjeva Mihaela

Discovery of 2-(2-benzoxazoyl amino)-4-aryl-5-cyanopyrimidine as negative allosteric modulators (NAMs) of metabotropic glutamate receptor 5 (mGlu₅): from an artificial neural network virtual screen to an in vivo tool compound

发现 2-(2-苯并恶唑基氨基)-4-芳基-5-氰基嘧啶作为代谢型谷氨酸受体 5 (mGlu₅) 的负变构调节剂 (NAM)：从人工神经网络虚拟筛选到体内工具化合物

期刊:ChemMedChem

影响因子:3.4

doi:10.1002/cmdc.201100510

Mueller, Ralf; Dawson, Eric S; Meiler, Jens; Rodriguez, Alice L; Chauder, Brian A; Bates, Brittney S; Felts, Andrew S; Lamb, Jeffrey P; Menon, Usha N; Jadhav, Sataywan B; Kane, Alexander S; Jones, Carrie K; Gregory, Karen J; Niswender, Colleen M; Conn, P Jeffrey; Olsen, Christopher M; Winder, Danny G; Emmitte, Kyle A; Lindsley, Craig W

Improved synthesis of UDP-2-(2-ketopropyl)galactose and a first synthesis of UDP-2-(2-ketopropyl)glucose for the site-specific linking of biomolecules via modified glycan residues using glycosyltransferases

利用糖基转移酶，通过修饰的聚糖残基，对UDP-2-(2-酮丙基)半乳糖进行改进合成，并首次合成UDP-2-(2-酮丙基)葡萄糖，用于生物分子的位点特异性连接。

期刊:Tetrahedron

影响因子:2.2

doi:10.1016/j.tet.2011.01.081

Dulcey, Andrés E; Qasba, Pradman K; Lamb, Jeffrey; Griffiths, Gary L

发表日期：2011

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Discovery of molecular switches within the ADX-47273 mGlu5 PAM scaffold that modulate modes of pharmacology to afford potent mGlu5 NAMs, PAMs and partial antagonists

在 ADX-47273 mGlu5 PAM 支架中发现分子开关，这些开关可调节药理学模式，从而产生强效的 mGlu5 NAM、PAM 和部分拮抗剂。

期刊:Bioorganic & Medicinal Chemistry Letters

影响因子:2.2

doi:10.1016/j.bmcl.2010.11.119

Lamb, Jeffrey P; Engers, Darren W; Niswender, Colleen M; Rodriguez, Alice L; Venable, Daryl F; Conn, P Jeffrey; Lindsley, Craig W

发表日期：2011

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3-Cyano-5-fluoro-N-arylbenzamides as negative allosteric modulators of mGlu(5): Identification of easily prepared tool compounds with CNS exposure in rats

3-氰基-5-氟-N-芳基苯甲酰胺作为mGlu(5)的负变构调节剂：易于制备的工具化合物在大鼠中枢神经系统暴露中的鉴定

期刊:Bioorganic & Medicinal Chemistry Letters

影响因子:2.2

doi:10.1016/j.bmcl.2010.06.064

Felts, Andrew S; Lindsley, Stacey R; Lamb, Jeffrey P; Rodriguez, Alice L; Menon, Usha N; Jadhav, Satyawan; Jones, Carrie K; Conn, P Jeffrey; Lindsley, Craig W; Emmitte, Kyle A

rRNA transcription is integral to phase separation and maintenance of nucleolar structure

rRNA 转录是相分离和核仁结构维持不可或缺的部分

Key Parameters of Tumor Epitope Immunogenicity Revealed Through a Consortium Approach Improve Neoantigen Prediction

通过联合研究方法揭示肿瘤表位免疫原性的关键参数，从而改进新抗原预测

Neutrophil L-Plastin Controls Ocular Paucibacteriality and Susceptibility to Keratitis.

中性粒细胞 L-Plastin 控制眼部细菌稀少性和角膜炎易感性

Discovery of 2-(2-benzoxazoyl amino)-4-aryl-5-cyanopyrimidine as negative allosteric modulators (NAMs) of metabotropic glutamate receptor 5 (mGlu₅): from an artificial neural network virtual screen to an in vivo tool compound

发现 2-(2-苯并恶唑基氨基)-4-芳基-5-氰基嘧啶作为代谢型谷氨酸受体 5 (mGlu₅) 的负变构调节剂 (NAM)：从人工神经网络虚拟筛选到体内工具化合物

Improved synthesis of UDP-2-(2-ketopropyl)galactose and a first synthesis of UDP-2-(2-ketopropyl)glucose for the site-specific linking of biomolecules via modified glycan residues using glycosyltransferases

利用糖基转移酶，通过修饰的聚糖残基，对UDP-2-(2-酮丙基)半乳糖进行改进合成，并首次合成UDP-2-(2-酮丙基)葡萄糖，用于生物分子的位点特异性连接。

Discovery of molecular switches within the ADX-47273 mGlu5 PAM scaffold that modulate modes of pharmacology to afford potent mGlu5 NAMs, PAMs and partial antagonists

在 ADX-47273 mGlu5 PAM 支架中发现分子开关，这些开关可调节药理学模式，从而产生强效的 mGlu5 NAM、PAM 和部分拮抗剂。

3-Cyano-5-fluoro-N-arylbenzamides as negative allosteric modulators of mGlu(5): Identification of easily prepared tool compounds with CNS exposure in rats

3-氰基-5-氟-N-芳基苯甲酰胺作为mGlu(5)的负变构调节剂：易于制备的工具化合物在大鼠中枢神经系统暴露中的鉴定