日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Targeting protein-ligand neosurfaces with a generalizable deep learning tool

使用可通用的深度学习工具靶向蛋白质-配体新表面

Anthony Marchand #, Stephen Buckley #, Arne Schneuing #, Martin Pacesa, Maddalena Elia, Pablo Gainza, Evgenia Elizarova, Rebecca M Neeser, Pao-Wan Lee, Luc Reymond, Yangyang Miao, Leo Scheller, Sandrine Georgeon, Joseph Schmidt, Philippe Schwaller, Sebastian J Maerkl, Michael Bronstein, Bruno E Corr

Protein-based bandpass filters for controlling cellular signaling with chemical inputs

基于蛋白质的带通滤波器用于通过化学输入控制细胞信号传导

Sailan Shui, Leo Scheller, Bruno E Correia

Dual ON/OFF-switch chimeric antigen receptor controlled by two clinically approved drugs

由两种临床批准的药物控制的双开关嵌合抗原受体

Greta Maria Paola Giordano Attianese, Sailan Shui, Elisabetta Cribioli, Melanie Triboulet, Leo Scheller, Morteza Hafezi, Patrick Reichenbach, Pablo Gainza, Sandrine Georgeon, Bruno E Correia, Melita Irving

Rational Design of Chemically Controlled Antibodies and Protein Therapeutics

化学控制抗体和蛋白质治疗的合理设计

Anthony Marchand, Lucia Bonati, Sailan Shui, Leo Scheller, Pablo Gainza, Stéphane Rosset, Sandrine Georgeon, Li Tang, Bruno E Correia

Programmable DARPin-based receptors for the detection of thrombotic markers

可编程 DARPin 受体用于检测血栓标志物

Tobias Strittmatter, Yidan Wang, Adrian Bertschi, Leo Scheller, Patrick C Freitag, Preetam Guha Ray, Pascal Stuecheli, Jonas V Schaefer, Thomas Reinberg, Dimitrios Tsakiris, Andreas Plückthun, Haifeng Ye, Martin Fussenegger

A rational blueprint for the design of chemically-controlled protein switches

化学控制蛋白质开关设计的合理蓝图

Sailan Shui, Pablo Gainza, Leo Scheller, Che Yang, Yoichi Kurumida, Stéphane Rosset, Sandrine Georgeon, Raphaël B Di Roberto, Rocío Castellanos-Rueda, Sai T Reddy, Bruno E Correia

Genetically encoded betaxanthin-based small-molecular fluorescent reporter for mammalian cells

用于哺乳动物细胞的基因编码的基于甜菜黄素的小分子荧光报告基因

Pascal Stücheli, Simon Sieber, David W Fuchs, Leo Scheller, Tobias Strittmatter, Pratik Saxena, Karl Gademann, Martin Fussenegger

Phosphoregulated orthogonal signal transduction in mammalian cells

哺乳动物细胞中的磷酸调节正交信号转导

Leo Scheller, Marc Schmollack, Adrian Bertschi, Maysam Mansouri, Pratik Saxena, Martin Fussenegger

Rewiring of endogenous signaling pathways to genomic targets for therapeutic cell reprogramming

将内源性信号通路重新连接到基因组靶点,用于治疗性细胞重编程

Krzysztof Krawczyk, Leo Scheller, Hyojin Kim, Martin Fussenegger

A modular degron library for synthetic circuits in mammalian cells

用于哺乳动物细胞合成电路的模块化降解单元库

Hélène Chassin, Marius Müller, Marcel Tigges, Leo Scheller, Moritz Lang, Martin Fussenegger