日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Blocking LIF and PD-L1 enhances the antitumor efficacy of SBRT in murine PDAC models.

阻断 LIF 和 PD-L1 可增强 SBRT 在小鼠 PDAC 模型中的抗肿瘤疗效

Ye Jian, Qin Shuyang S, Hughson Angela L, Hannon Gary, Salama Noah A, Vrooman Tara G, Lesch Maggie L, Lesser Sidney, Eckl Sarah L, Jewell Rachel, Benoodt Lauren, Mills Bradley N, Johnston Carl J, Lord Edith, Belt Brian A, Calvi Laura M, Linehan David, Luheshi Nadia, Eyles Jim, Gerber Scott A

Blockade of LIF and PD-L1 Enhances Chemotherapy in Preclinical PDAC Models

阻断 LIF 和 PD-L1 可增强临床前 PDAC 模型中的化疗效果

Ye, Jian; Qin, Shuyang S; Hughson, Angela L; Hannon, Gary; Vrooman, Tara G; Lesch, Maggie L; Eckl, Sarah L; Benoodt, Lauren; Mills, Bradley N; Lord, Edith M; Belt, Brian A; Linehan, David C; Luheshi, Nadia; Eyles, Jim; Gerber, Scott A

Intratumoral IL12 mRNA administration activates innate and adaptive pathways in checkpoint inhibitor resistant tumors resulting in complete responses.

肿瘤内注射IL12 mRNA可激活免疫检查点抑制剂耐药肿瘤的先天性和适应性免疫通路,从而产生完全缓解

Lakshmipathi Jayalakshmi, Santha Sreevidya, Li Man, Qian Yuping, Roy Simon F, Luheshi Nadia, Politi Katerina, Bosenberg Marcus, Eyles Jim, Muthusamy Viswanathan

Extensive Biotransformation Profiling of AZD8205, an Anti-B7-H4 Antibody-Drug Conjugate, Elucidates Pathways Underlying Its Stability In Vivo

对抗B7-H4抗体-药物偶联物AZD8205进行广泛的生物转化分析,阐明了其体内稳定性的潜在途径

Huang, Yue; Tan, Hui Yin; Yuan, Jiaqi; Mu, Ruipeng; Yang, Junyan; Ball, Kathryn; Vijayakrishnan, Balakumar; Masterson, Luke; Kinneer, Krista; Luheshi, Nadia; Liang, Meina; Rosenbaum, Anton I

Integrating IL-12 mRNA nanotechnology with SBRT eliminates T cell exhaustion in preclinical models of pancreatic cancer.

将 IL-12 mRNA 纳米技术与 SBRT 相结合,可消除胰腺癌临床前模型中的 T 细胞耗竭

Hughson Angela L, Hannon Gary, Salama Noah A, Vrooman Tara G, Stockwell Caroline A, Mills Bradley N, Garrett-Larsen Jesse, Qiu Haoming, Katerji Roula, Benoodt Lauren, Johnston Carl J, Murphy Joseph D, Kruger Emma, Ye Jian, Gavras Nicholas W, Keeley David C, Qin Shuyang S, Lesch Maggie L, Muhitch Jason B, Love Tanzy M T, Calvi Laura M, Lord Edith M, Luheshi Nadia, Elyes Jim, Linehan David C, Gerber Scott A

A mechanistic PK/PD model of AZD0171 (anti-LIF) to support Phase II dose selection

AZD0171(抗LIF)的机制性PK/PD模型,用于支持II期剂量选择

Shahraz, Azar; Penney, Mark; Candido, Juliana; Opoku-Ansah, Grace; Neubauer, Melanie; Eyles, Jim; Ojo, Oluwaseun; Liu, Nelson; Luheshi, Nadia M; Phipps, Alex; Vishwanathan, Karthick

Understanding the influence of the tumor microenvironment on macrophage responses to CD40 agonists

了解肿瘤微环境对巨噬细胞CD40激动剂反应的影响

Luheshi, Nadia; Davies, Gareth; Legg, James

Nuclear retention of IL-1 alpha by necrotic cells: a mechanism to dampen sterile inflammation

坏死细胞对IL-1α的核内滞留:一种抑制无菌性炎症的机制

Luheshi, Nadia M; McColl, Barry W; Brough, David

The dynamics and mechanisms of interleukin-1alpha and beta nuclear import.

白细胞介素-1α和β核输入的动力学和机制

Luheshi Nadia M, Rothwell Nancy J, Brough David