日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

ID2 Suppresses Multiple Myeloma Cell Proliferation by Repressing the Activity of the Transcription Factor TCF3.

ID2 通过抑制转录因子 TCF3 的活性来抑制多发性骨髓瘤细胞增殖。

Fulciniti Mariateresa, Yao Yao, Perini Tommaso, Fong Ng Jessica, Schavgoulidze Anaïs, Deng Shuhui, Cui Jian, Encinas Mayoral Jessica, Ladisa Francesco, Young Ryan M, Epstein Charles B, White Cassandra M, Ott Christopher J, Gulla Annamaria, Matulis Shannon M, Sperling Adam S, Morelli Eugenio, Boise Lawrence H, Binder Moritz, Szalat Raphael, Samur Mehmet K, Anderson Kenneth C, Munshi Nikhil C

A Dimeric Rocaglate Promotes Multivalent eIF4A-RNA Assembly.

二聚体罗卡格酸酯促进多价eIF4A-RNA组装。

Liu Jie, Moore Megan K, Lou Kevin, Wassarman Douglas R, Arab Abolfazl, Ojeda Samuel, Karakyriakou Barbara, Koglin Ann-Sophie, Ott Christopher J, Gilbert Luke A, Shokat Kevan M

Oxidation of retromer complex controls mitochondrial translation

逆转录酶复合物的氧化控制线粒体翻译

Zhang, Junbing; Ali, Md Yousuf; Chong, Harrison Byron; Tien, Pei-Chieh; Woods, James; Noble, Carolina; Vornbäumen, Tristan; Ordulu, Zehra; Possemato, Anthony P; Harry, Stefan; Fonticella, Jay Miguel; Fellah, Lina; Harrison, Drew; Ge, Maolin; Khandelwal, Neha; Huang, Yingfei; Chauvin, Maëva; Bischof, Anica Tamara; Hambelton, Grace Marie; Gohar, Magdy Farag; Zhang, Siwen; Choi, MinGyu; Bouberhan, Sara; Oliva, Esther; Mino-Kenudson, Mari; Pavlova, Natalya N; Lawrence, Michael; Gainor, Justin F; Beausoleil, Sean A; Bardeesy, Nabeel; Mostoslavsky, Raul; Pépin, David; Ott, Christopher J; Liau, Brian; Bar-Peled, Liron

Correction: DNAJB1-PRKACA Fusion Drives Fibrolamellar Liver Cancer through Impaired SIK Signaling and CRTC2/p300-Mediated Transcriptional Reprogramming

更正:DNAJB1-PRKACA融合通过损害SIK信号传导和CRTC2/p300介导的转录重编程驱动纤维板层型肝癌

Gritti, Ilaria; Wan, Jinkai; Weeresekara, Vajira; Vaz, Joel M; Tarantino, Giuseppe; Bryde, Tenna Holgersen; Vijay, Vindhya; Kammula, Ashwin V; Kattel, Prabhat; Zhu, Songli; Vu, Phuong; Chan, Marina; Wu, Meng-Ju; Gordan, John D; Patra, Krushna C; Silveira, Vanessa S; Manguso, Robert T; Wein, Marc N; Ott, Christopher J; Qi, Jun; Liu, David; Sakamoto, Kei; Gujral, Taranjit S; Bardeesy, Nabeel

DNAJB1-PRKACA Fusion Drives Fibrolamellar Liver Cancer through Impaired SIK Signaling and CRTC2/p300-Mediated Transcriptional Reprogramming.

DNAJB1-PRKACA融合通过损害SIK信号传导和CRTC2/p300介导的转录重编程驱动纤维板层肝癌

Gritti Ilaria, Wan Jinkai, Weeresekara Vajira, Vaz Joel M, Tarantino Giuseppe, Bryde Tenna Holgersen, Vijay Vindhya, Kammula Ashwin V, Kattel Prabhat, Zhu Songli, Vu Phuong, Chan Marina, Wu Meng-Ju, Gordan John D, Patra Krushna C, Silveira Vanessa S, Manguso Robert T, Wein Marc N, Ott Christopher J, Qi Jun, Liu David, Sakamoto Kei, Gujral Taranjit S, Bardeesy Nabeel

Targeted degradation of CDK9 potently disrupts the MYC-regulated network.

靶向降解 CDK9 可有效破坏 MYC 调控网络

Toure Mohammed A, Motoyama Keisuke, Xiang Yichen, Urgiles Julie, Kabinger Florian, Koglin Ann-Sophie, Iyer Ramya S, Gagnon Kaitlyn, Kumar Amruth, Ojeda Samuel, Harrison Drew A, Rees Matthew G, Roth Jennifer A, Ott Christopher J, Schiavoni Richard, Whittaker Charles A, Levine Stuart S, White Forest M, Calo Eliezer, Richters Andre, Koehler Angela N

Structure-Guided Design of ISOX-DUAL-Based Degraders Targeting BRD4 and CBP/EP300: A Case of Degrader Collapse.

基于 ISOX-DUAL 的结构导向降解剂设计:针对 BRD4 和 CBP/EP300 的降解剂崩溃案例

Edmonds Anthony K, Balourdas Dimitrios-Ilias, Marsh Graham P, Felix Robert, Brasher Bradley, Cooper Jeff, Graber-Feesl Cari, Kollareddy Madhu, Malik Karim, Stewart Helen, Chevassut Timothy J T, Lineham Ella, Morley Simon, Fedorov Oleg, Bennett James, Rajasekaran Mohan B, Ojeda Samuel, Harrison Drew A, Ott Christopher J, Joerger Andreas C, Maple Hannah J, Spencer John

p300/CBP is an essential driver of pathogenic enhancer activity and gene expression in Ewing sarcoma.

p300/CBP 是尤文氏肉瘤中致病增强子活性和基因表达的重要驱动因素。

Godfrey Laura C, Regalado Brandon, Schweber Sydney R, Hatton Charles, Wenge Daniela V, Wen Yanhe, Boileau Meaghan, Wessels Maria, Qi Jun, Ott Christopher J, Stegmaier Kimberly, Rivera Miguel N, Armstrong Scott A

Targeting Monounsaturated Fatty Acid Metabolism for Radiosensitization of KRAS Mutant 3D Lung Cancer Models.

靶向单不饱和脂肪酸代谢以增强 KRAS 突变 3D 肺癌模型的放射敏感性

Lu Shan, Pan Xiao, Volckova Eva, Shinde Anjali, Fuller Schuyler R, Egan Regina, Ma Jianli, Kung Jong, Ott Christopher J, Hata Aaron N, Benes Cyril H, Kang Jing X, Willers Henning

Development of p300-targeting degraders with enhanced selectivity and onset of degradation.

开发具有增强选择性和更快降解速度的p300靶向降解剂

Marsh Graham P, Cooper Mark S, Goggins Sean, Reynolds Stephen J, Wheeler Dean F, Cresser-Brown Joel O, Arnold Robert E, Babcock Emily G, Hughes Gareth, Bosnakovski Darko, Kyba Michael, Ojeda Samuel, Harrison Drew A, Ott Christopher J, Maple Hannah J