日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Chronic Ketosis Provides Neuroprotection Through HIF- 1α-Mediated Control of the TXNIP/NLRP3 Axis by Regulating the Inflammatory and Apoptotic Response.

慢性酮症通过 HIF-1α 介导的 TXNIP/NLRP3 轴控制来调节炎症和凋亡反应,从而提供神经保护作用

Parveen Kehkashan, Salman Mohd, Mirzahosseini Golnoush, Parveen Arshi, Ishrat Tauheed, Puchowicz Michelle A

Direct and systemic actions of growth hormone receptor (GHR)-signaling on hepatic glycolysis, de novo lipogenesis and insulin sensitivity, associated with steatosis

生长激素受体 (GHR) 信号对肝糖酵解、从头脂肪生成和胰岛素敏感性的直接和系统性作用与脂肪变性相关

Vázquez-Borrego, Mari C; Del Río-Moreno, Mercedes; Pyatkov, Maxim; Sarmento-Cabral, André; Mahmood, Mariyah; Pelke, Natalie; Wnek, Magdalena; Cordoba-Chacon, Jose; Waxman, David J; Puchowicz, Michelle A; McGuinness, Owen P; Kineman, Rhonda D

Brain insulin signaling suppresses lipolysis in the absence of peripheral insulin receptors and requires the MAPK pathway

在没有外周胰岛素受体的情况下,大脑胰岛素信号抑制脂肪分解,并且需要 MAPK 通路

Matthäus Metz, James O'Hare, Bob Cheng, Michelle Puchowicz, Christoph Buettner, Thomas Scherer

Loss of Ptpmt1 limits mitochondrial utilization of carbohydrates and leads to muscle atrophy and heart failure in tissue-specific knockout mice

Ptpmt1 的缺失会限制线粒体对碳水化合物的利用,并导致组织特异性敲除小鼠的肌肉萎缩和心力衰竭

Hong Zheng #, Qianjin Li #, Shanhu Li #, Zhiguo Li, Marco Brotto, Daiana Weiss, Domenick Prosdocimo, Chunhui Xu, Ashruth Reddy, Michelle Puchowicz, Xinyang Zhao, M Neale Weitzmann, Mukesh K Jain, Cheng-Kui Qu

Effect of statin treatment on metabolites, lipids and prostanoids in patients with Statin Associated Muscle Symptoms (SAMS)

他汀类药物治疗对他汀类药物相关肌肉症状 (SAMS) 患者的代谢物、脂质和前列腺素的影响

Timothy J Garrett, Michelle A Puchowicz, Edwards A Park, Qingming Dong, Gregory Farage, Richard Childress, Joy Guingab, Claire L Simpson, Saunak Sen, Elizabeth C Brogdon, Logan M Buchanan, Rajendra Raghow, Marshall B Elam

Chronic intake of high dietary sucrose induces sexually dimorphic metabolic adaptations in mouse liver and adipose tissue

长期摄入高膳食蔗糖可诱导小鼠肝脏和脂肪组织发生性别差异代谢适应

Erin J Stephenson, Amanda S Stayton, Aarti Sethuraman, Prahlad K Rao, Alice Meyer, Charles Klazer Gomes, Molly C Mulcahy, Liam McAllan, Michelle A Puchowicz, Joseph F Pierre, Dave Bridges, Joan C Han

A mitochondrial long-chain fatty acid oxidation defect leads to transfer RNA uncharging and activation of the integrated stress response in the mouse heart

线粒体长链脂肪酸氧化缺陷导致转移 RNA 释放并激活小鼠心脏中的综合应激反应

Pablo Ranea-Robles, Natalya N Pavlova, Aaron Bender, Andrea S Pereyra, Jessica M Ellis, Brandon Stauffer, Chunli Yu, Craig B Thompson, Carmen Argmann, Michelle Puchowicz, Sander M Houten

Acute Hyperglycemia Exacerbates Hemorrhagic Transformation after Embolic Stroke and Reperfusion with tPA: A Possible Role of TXNIP-NLRP3 Inflammasome

急性高血糖加剧栓塞性卒中和 tPA 再灌注后的出血性转化:TXNIP-NLRP3 炎症小体的可能作用

Mohd Salman, Saifudeen Ismael, Lexiao Li, Heba A Ahmed, Michelle A Puchowicz, Tauheed Ishrat

Obesity-Dependent Adipokine Chemerin Suppresses Fatty Acid Oxidation to Confer Ferroptosis Resistance

肥胖依赖性脂肪因子趋化素抑制脂肪酸氧化,从而赋予细胞抵抗铁死亡的能力。

Sze Kiat Tan ,Iqbal Mahmud ,Flavia Fontanesi ,Michelle Puchowicz ,Chase K A Neumann ,Anthony J Griswold ,Rutulkumar Patel ,Marco Dispagna ,Hamzah H Ahmed ,Mark L Gonzalgo ,J Mark Brown ,Timothy J Garrett ,Scott M Welford

Novel role of xanthine oxidase-dependent H2O2 production in 12/15-lipoxygenase-mediated de novo lipogenesis, triglyceride biosynthesis and weight gain

黄嘌呤氧化酶依赖性H2O2生成在12/15-脂氧合酶介导的从头脂肪生成、甘油三酯生物合成和体重增加中的新作用

Suresh Govatati ,Prahalathan Pichavaram ,Arul M Mani ,Raj Kumar ,Deepti Sharma ,Ari Dienel ,Sunita Meena ,Michelle A Puchowicz ,Edwards A Park ,Gadiparthi N Rao