日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The new Bruton's tyrosine kinase inhibitors SPA8007 and SPA8009 reduce stemness and invasiveness of patient-derived glioblastoma tumorspheres

新型布鲁顿酪氨酸激酶抑制剂SPA8007和SPA8009可降低患者来源的胶质母细胞瘤肿瘤球的干性和侵袭性。

Jo, Euna; Lee, Eun; Oh, Yoojung; Lee, Dongkyu; Lee, Byungho; Kim, Kibyeong; Choi, Ran Joo; Hong, Jiyun; Jeon, Yuesong; Cho, Hyewon; Choi, Yong-Sung; Kim, Sangwoo; Won, So Young; Choi, Seonah; Roh, Tae Hoon; Moon, Ju Hyung; Kim, Eui Hyun; Chang, Jong Hee; Jeon, Raok; Kang, Seok-Gu

Exploring structural and biological insights of TEAD through rational design and synthesis of niflumic acid derivatives

通过合理设计和合成尼氟酸衍生物,探索TEAD的结构和生物学特性

Yong-Sung Choi ,Yoon-Jung Kim ,Yeram Jeon ,Jong Soon Kang ,Juhee Lee ,Eunmi Hong ,Young-Hoon Park ,Wantae Kim ,Boksik Cha ,Raok Jeon

The potential anti-amyloidogenic candidate, SPA1413, for Alzheimer's disease

治疗阿尔茨海默病的潜在抗淀粉样变性候选药物 SPA1413

Seong Soo A An, Kyu Hwan Shim, Shinwoo Kang, Young Kyo Kim, Lalita Subedi, Hyewon Cho, Seong-Min Hong, Mario A Tan, Raok Jeon, Keun-A Chang, Sun Yeou Kim

Targeting p21-activated kinase 4 (PAK4) with pyrazolo[3,4- d]pyrimidine derivative SPA7012 attenuates hepatic ischaemia-reperfusion injury in mice

利用吡唑并[3,4- d]嘧啶衍生物 SPA7012 靶向 p21 活化激酶 4 (PAK4) 可减轻小鼠肝缺血再灌注损伤

Yuancheng Mao, Eun Lee, Xiaohui Yang, Eun Ju Bae, Raok Jeon, Byung-Hyun Park

Identifying the natural polyphenol catechin as a multi-targeted agent against SARS-CoV-2 for the plausible therapy of COVID-19: an integrated computational approach

鉴定天然多酚儿茶素作为抗SARS-CoV-2多靶点药物,用于COVID-19的潜在治疗:一种综合计算方法

Mishra, Chandra Bhushan; Pandey, Preeti; Sharma, Ravi Datta; Malik, Md Zubbair; Mongre, Raj Kumar; Lynn, Andrew M; Prasad, Rajendra; Jeon, Raok; Prakash, Amresh

Anti-breast cancer action of carbonic anhydrase IX inhibitor 4-[4-(4-Benzo[1,3]dioxol-5-ylmethyl-piperazin-1-yl)-benzylidene-hydrazinocarbonyl]-benzenesulfonamide (BSM-0004): in vitro and in vivo studies

碳酸酐酶 IX 抑制剂 4-[4-(4-苯并[1,3]二氧杂环戊烯-5-基甲基-哌嗪-1-基)-苄亚甲基-肼基羰基]-苯磺酰胺 (BSM-0004) 的抗乳腺癌作用:体外和体内研究

Chandra Bhushan Mishra, Raj Kumar Mongre, Amresh Prakash, Raok Jeon, Claudiu T Supuran, Myeong-Sok Lee

Anti-inflammatory Effects of S. cumini Seed Extract on Gelatinase-B (MMP-9) Regulation against Hyperglycemic Cardiomyocyte Stress

孜然籽提取物对明胶酶B(MMP-9)调节的抗炎作用及其对高血糖心肌细胞应激的影响

Atale, Neha; Mishra, Chandra Bhushan; Kohli, Shrey; Mongre, Raj Kumar; Prakash, Amresh; Kumari, Sweta; Yadav, Umesh C S; Jeon, Raok; Rani, Vibha

Discovery of 5-Phenoxy-2-aminopyridine Derivatives as Potent and Selective Irreversible Inhibitors of Bruton's Tyrosine Kinase

发现 5-苯氧基-2-氨基吡啶衍生物作为布鲁顿酪氨酸激酶的强效和选择性不可逆抑制剂

Eun Lee, Hyewon Cho, Da Kyung Lee, JuHyun Ha, Byeong Jo Choi, Ji Hye Jeong, Jae-Ha Ryu, Jong Soon Kang, Raok Jeon

Discovery of Tricyclic Pyranochromenone as Novel Bruton's Tyrosine Kinase Inhibitors with in Vivo Antirheumatic Activity

发现三环吡喃色原酮作为新型布鲁顿酪氨酸激酶抑制剂,具有体内抗风湿活性

Hyewon Cho, Eun Lee, Hye Ah Kwon, Lee Seul, Hui-Jeon Jeon, Ji Hoon Yu, Jae-Ha Ryu, Raok Jeon

SPA0355 prevents ovariectomy-induced bone loss in mice

SPA0355 可预防小鼠卵巢切除引起的骨质流失

Sang Hoon Kim, Zhongkai Zhang, Young Jae Moon, Il Woon Park, Yong Gon Cho, Raok Jeon, Byung-Hyun Park