日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Co-occurring gain-of-function mutations in HER2 and HER3 modulate HER2/HER3 activation, oncogenesis, and HER2 inhibitor sensitivity

HER2 和 HER3 同时发生的获得功能突变会调节 HER2/HER3 活化、肿瘤发生和 HER2 抑制剂敏感性

Ariella B Hanker, Benjamin P Brown, Jens Meiler, Arnaldo Marín, Harikrishna S Jayanthan, Dan Ye, Chang-Ching Lin, Hiroaki Akamatsu, Kyung-Min Lee, Sumanta Chatterjee, Dhivya R Sudhan, Alberto Servetto, Monica Red Brewer, James P Koch, Jonathan H Sheehan, Jie He, Alshad S Lalani, Carlos L Arteaga

Structure-function analysis of oncogenic EGFR Kinase Domain Duplication reveals insights into activation and a potential approach for therapeutic targeting

致癌 EGFR 激酶结构域重复的结构功能分析揭示了激活的见解和治疗靶向的潜在方法

Zhenfang Du #, Benjamin P Brown #, Soyeon Kim, Donna Ferguson, Dean C Pavlick, Gowtham Jayakumaran, Ryma Benayed, Jean-Nicolas Gallant, Yun-Kai Zhang, Yingjun Yan, Monica Red-Brewer, Siraj M Ali, Alexa B Schrock, Ahmet Zehir, Marc Ladanyi, Adam W Smith, Jens Meiler, Christine M Lovly

Hyperactivation of TORC1 Drives Resistance to the Pan-HER Tyrosine Kinase Inhibitor Neratinib in HER2-Mutant Cancers

TORC1 过度激活导致 HER2 突变型癌症对泛 HER 酪氨酸激酶抑制剂 Neratinib 产生耐药性

Dhivya R Sudhan, Angel Guerrero-Zotano, Helen Won, Paula González Ericsson, Alberto Servetto, Mariela Huerta-Rosario, Dan Ye, Kyung-Min Lee, Luigi Formisano, Yan Guo, Qi Liu, Lisa N Kinch, Monica Red Brewer, Teresa Dugger, James Koch, Michael J Wick, Richard E Cutler Jr, Alshad S Lalani, Richard Bry

An Acquired HER2T798I Gatekeeper Mutation Induces Resistance to Neratinib in a Patient with HER2 Mutant-Driven Breast Cancer

获得性 HER2T798I 门控突变导致 HER2 突变驱动乳腺癌患者对 Neratinib 产生耐药性

Ariella B Hanker, Monica Red Brewer, Jonathan H Sheehan, James P Koch, Gregory R Sliwoski, Rebecca Nagy, Richard Lanman, Michael F Berger, David M Hyman, David B Solit, Jie He, Vincent Miller, Richard E Cutler Jr, Alshad S Lalani, Darren Cross, Christine M Lovly, Jens Meiler, Carlos L Arteaga2

An ERBB1-3 Neutralizing Antibody Mixture With High Activity Against Drug-Resistant HER2+ Breast Cancers With ERBB Ligand Overexpression

一种对耐药性 HER2+ 乳腺癌(ERBB 配体过表达)具有高活性的 ERBB1-3 中和抗体混合物

Schwarz, Luis J; Hutchinson, Katherine E; Rexer, Brent N; Estrada, Mónica Valeria; Gonzalez Ericsson, Paula I; Sanders, Melinda E; Dugger, Teresa C; Formisano, Luigi; Guerrero-Zotano, Angel; Red-Brewer, Monica; Young, Christian D; Lantto, Johan; Pedersen, Mikkel W; Kragh, Michael; Horak, Ivan D; Arteaga, Carlos L

JAK2 inhibition sensitizes resistant EGFR-mutant lung adenocarcinoma to tyrosine kinase inhibitors

JAK2 抑制使耐药 EGFR 突变肺腺癌对酪氨酸激酶抑制剂敏感

Sizhi P Gao, Qing Chang, Ninghui Mao, Laura A Daly, Robert Vogel, Tyler Chan, Shu Hui Liu, Eirini Bournazou, Erez Schori, Haiying Zhang, Monica Red Brewer, William Pao, Luc Morris, Marc Ladanyi, Maria Arcila, Katia Manova-Todorova, Elisa de Stanchina, Larry Norton, Ross L Levine, Gregoire Altan-Bonn

EGFR Kinase Domain Duplication (EGFR-KDD) Is a Novel Oncogenic Driver in Lung Cancer That Is Clinically Responsive to Afatinib

EGFR 激酶结构域重复 (EGFR-KDD) 是肺癌中一种新的致癌驱动因素,对阿法替尼具有临床反应

Jean-Nicolas Gallant, Jonathan H Sheehan, Timothy M Shaver, Mark Bailey, Doron Lipson, Raghu Chandramohan, Monica Red Brewer, Sally J York, Mark G Kris, Jennifer A Pietenpol, Marc Ladanyi, Vincent A Miller, Siraj M Ali, Jens Meiler, Christine M Lovly

HER2 missense mutations have distinct effects on oncogenic signaling and migration

HER2 错义突变对致癌信号和迁移有明显影响

Daniel J Zabransky, Christopher L Yankaskas, Rory L Cochran, Hong Yuen Wong, Sarah Croessmann, David Chu, Shyam M Kavuri, Monica Red Brewer, D Marc Rosen, W Brian Dalton, Ashley Cimino-Mathews, Karen Cravero, Berry Button, Kelly Kyker-Snowman, Justin Cidado, Bracha Erlanger, Heather A Parsons, Krist

AZD9291, an irreversible EGFR TKI, overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer

AZD9291 是一种不可逆的 EGFR TKI,可克服肺癌中 T790M 介导的对 EGFR 抑制剂的耐药性

Darren A E Cross, Susan E Ashton, Serban Ghiorghiu, Cath Eberlein, Caroline A Nebhan, Paula J Spitzler, Jonathon P Orme, M Raymond V Finlay, Richard A Ward, Martine J Mellor, Gareth Hughes, Amar Rahi, Vivien N Jacobs, Monica Red Brewer, Eiki Ichihara, Jing Sun, Hailing Jin, Peter Ballard, Katherine

LYN-activating mutations mediate antiestrogen resistance in estrogen receptor-positive breast cancer

LYN 激活突变介导雌激素受体阳性乳腺癌的抗雌激素耐药性

Luis J Schwarz, Emily M Fox, Justin M Balko, Joan T Garrett, María Gabriela Kuba, Mónica Valeria Estrada, Ana María González-Angulo, Gordon B Mills, Monica Red-Brewer, Ingrid A Mayer, Vandana Abramson, Monica Rizzo, Mark C Kelley, Ingrid M Meszoely, Carlos L Arteaga