Rilei Yu相关文献与解析，生知库 | 链接生命科学的每一步

Min Li #, Zheng Wang #, Jingjing Tao #, Hongfei Jiang, Huang Yang, Dong Guo, Hong Zhao, Xuxiao He, Shudi Luo, Xiaoming Jiang, Li Yuan, Liwei Xiao, Haiyan He, Rilei Yu, Jing Fang, Tingbo Liang, Zhengwei Mao, Daqian Xu, Zhimin Lu

肿瘤

表观遗传

发表日期：2024

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Discovery of a pyrrole-pyridinimidazole derivative as novel SIRT6 inhibitor for sensitizing pancreatic cancer to gemcitabine

发现吡咯-吡啶咪唑衍生物作为新型 SIRT6 抑制剂，可增强胰腺癌对吉西他滨的敏感性

期刊:Cell Death & Disease

影响因子:8.1

doi:10.1038/s41419-023-06018-1

Nannan Song #, Xian Guan #, Siqi Zhang, Yanqing Wang, Xuekai Wang, Zhongxia Lu, Daochen Chong, Jennifer Yiyang Wang, Rilei Yu, Wengong Yu, Tao Jiang, Yuchao Gu

Design and syntheses of a bimolecular STING agonist based on the covalent STING antagonist

基于共价 STING 拮抗剂的双分子 STING 激动剂的设计和合成

期刊:European Journal of Medicinal Chemistry

影响因子:6

doi:10.1016/j.ejmech.2023.115184

Ruochen Zang, Liang Xue, Meifang Zhang, Xiaoyue Peng, Xionghao Li, Kaixin Du, Chuanqin Shi, Yuqian Liu, Yuxi Lin, Wenwei Han, Rilei Yu, Qian Wang, Jinbo Yang, Xin Wang, Tao Jiang

信号转导

发表日期：2023

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Fructose-1,6-bisphosphatase 1 functions as a protein phosphatase to dephosphorylate histone H3 and suppresses PPARα-regulated gene transcription and tumour growth

果糖-1,6-双磷酸酶 1 作为一种蛋白磷酸酶，可使组蛋白 H3 去磷酸化，并抑制 PPARα 调节的基因转录和肿瘤生长

期刊:Nature Cell Biology

影响因子:17.3

doi:10.1038/s41556-022-01009-4

Zheng Wang #, Min Li #, Hongfei Jiang, Shudi Luo, Fei Shao, Yan Xia, Mengke Yang, Xiangle Ren, Tong Liu, Meisi Yan, Xu Qian, Haiyan He, Dong Guo, Yuran Duan, Ke Wu, Lei Wang, Guimei Ji, Yuli Shen, Lin Li, Peixiang Zheng, Bofei Dong, Jing Fang, Min Zheng, Tingbo Liang, Haitao Li, Rilei Yu, Daqian Xu,

Design, Synthesis and Evaluation of Novel Phorbazole C Derivatives as MNK Inhibitors through Virtual High-Throughput Screening

通过虚拟高通量筛选设计、合成和评估新型 Phorbazole C 衍生物作为 MNK 抑制剂

期刊:Marine Drugs

影响因子:4.9

doi:10.3390/md20070429

Xin Jin, Maowei Li, Tingting Qiu, Rilei Yu, Tao Jiang

发表日期：2022

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PGK1-coupled HSP90 stabilizes GSK3β expression to regulate the stemness of breast cancer stem cells

PGK1 偶联的 HSP90 稳定 GSK3β 表达来调节乳腺癌干细胞的干性

期刊:Cancer Biology & Medicine

影响因子:5.6

doi:10.20892/j.issn.2095-3941.2020.0362

Wei Tang, Yu Wu, Xin Qi, Rilei Yu, Zhimin Lu, Ao Chen, Xinglong Fan, Jing Li

Guanidine modifications enhance the anti-herpes simplex virus activity of (E,E)-4,6-bis(styryl)-pyrimidine derivatives in vitro and in vivo

胍修饰增强（E,E）-4,6-双（苯乙烯基）-嘧啶衍生物体外和体内的抗单纯疱疹病毒活性

期刊:British Journal of Pharmacology

影响因子:6.8

doi:10.1111/bph.14918

Wei Wang, Cuijing Xu, Jianqiang Zhang, Jinpeng Wang, Rilei Yu, Dongping Wang, Ruijuan Yin, Wenmiao Li, Tao Jiang

Antidiabetic activity in vitro and in vivo of BDB, a selective inhibitor of protein tyrosine phosphatase 1B, from Rhodomela confervoides

源自 Rhodomela confervoides 的蛋白酪氨酸磷酸酶 1B 选择性抑制剂 BDB 的体外和体内抗糖尿病活性

期刊:British Journal of Pharmacology

影响因子:6.8

doi:10.1111/bph.15195

Jiao Luo, Meiling Zheng, Bo Jiang, Chao Li, Shuju Guo, Lijun Wang, Xiangqian Li, Rilei Yu, Dayong Shi

Fructose-1,6-bisphosphatase 1 dephosphorylates and inhibits TERT for tumor suppression

果糖-1,6-双磷酸酶 1 去磷酸化并抑制 TERT，从而抑制肿瘤

Discovery of a pyrrole-pyridinimidazole derivative as novel SIRT6 inhibitor for sensitizing pancreatic cancer to gemcitabine

发现吡咯-吡啶咪唑衍生物作为新型 SIRT6 抑制剂，可增强胰腺癌对吉西他滨的敏感性

Design and syntheses of a bimolecular STING agonist based on the covalent STING antagonist

基于共价 STING 拮抗剂的双分子 STING 激动剂的设计和合成

Fructose-1,6-bisphosphatase 1 functions as a protein phosphatase to dephosphorylate histone H3 and suppresses PPARα-regulated gene transcription and tumour growth

果糖-1,6-双磷酸酶 1 作为一种蛋白磷酸酶，可使组蛋白 H3 去磷酸化，并抑制 PPARα 调节的基因转录和肿瘤生长

Design, Synthesis and Evaluation of Novel Phorbazole C Derivatives as MNK Inhibitors through Virtual High-Throughput Screening

通过虚拟高通量筛选设计、合成和评估新型 Phorbazole C 衍生物作为 MNK 抑制剂

PGK1-coupled HSP90 stabilizes GSK3β expression to regulate the stemness of breast cancer stem cells

PGK1 偶联的 HSP90 稳定 GSK3β 表达来调节乳腺癌干细胞的干性

Guanidine modifications enhance the anti-herpes simplex virus activity of (E,E)-4,6-bis(styryl)-pyrimidine derivatives in vitro and in vivo

胍修饰增强（E,E）-4,6-双（苯乙烯基）-嘧啶衍生物体外和体内的抗单纯疱疹病毒活性

Antidiabetic activity in vitro and in vivo of BDB, a selective inhibitor of protein tyrosine phosphatase 1B, from Rhodomela confervoides

源自 Rhodomela confervoides 的蛋白酪氨酸磷酸酶 1B 选择性抑制剂 BDB 的体外和体内抗糖尿病活性