日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Radionuclide Selection Influences Imaging Outcomes in Immuno-PET with a Brain-Penetrating Anti-Amyloid-β Antibody

放射性核素的选择会影响使用脑穿透性抗β-淀粉样蛋白抗体进行免疫PET成像的结果

Lopes van den Broek, Sara; Bratteby, Klas; Aguilar, Ximena; Tran, Thuy A; Syvänen, Stina; Sehlin, Dag

Pretargeted brain PET imaging reveals amyloid-β pathology using a TCO-modified antibody and a fluorine-18-labeled tetrazine.

预靶向脑部 PET 成像利用 TCO 修饰的抗体和氟-18 标记的四嗪揭示淀粉样蛋白-β 病理。

Lopes van den Broek Sara, Eriksson Jonas, Yang Qiaojun, Bucher Nadja M, Schlein Eva, Balestri Lorenzo J I, Odell Luke R, Sehlin Dag, Syvänen Stina

Astrocytic lipid droplets contain MHCII and may act as cogs in the antigen presentation machinery.

星形胶质细胞脂滴含有MHCII,可能在抗原呈递机制中发挥作用

Beretta Chiara, Dakhel Abdulkhalek, Eltom Khalid, Rosqvist Fredrik, Uzoni Simon, Mothes Tobias, Fletcher John S, Risérus Ulf, Sehlin Dag, Rostami Jinar, Michno Wojciech Piotr, Erlandsson Anna

Bispecific brain-penetrant antibodies for treatment of Alzheimer's disease

用于治疗阿尔茨海默病的双特异性脑穿透抗体

Sehlin, Dag; Hultqvist, Greta; Michno, Wojciech; Aguilar, Ximena; Dahlén, Amelia D; Cerilli, Enrica; Bucher, Nadja M; Lopes van den Broek, Sara; Syvänen, Stina

A brain-penetrant bispecific antibody lowers oligomeric alpha-synuclein and activates microglia in a mouse model of alpha-synuclein pathology.

在α-突触核蛋白病理小鼠模型中,一种可穿透血脑屏障的双特异性抗体可降低寡聚α-突触核蛋白水平并激活小胶质细胞

Sehlin Dag, Roshanbin Sahar, Zachrisson Olof, Ingelsson Martin, Syvänen Stina

Lowering the affinity of single-chain monovalent BBB shuttle scFc-scFv8D3 prolongs its half-life and increases brain concentration.

降低单链单价 BBB 穿梭分子 scFc-scFv8D3 的亲和力可延长其半衰期并提高其在大脑中的浓度

Rosa Andrés de la, Metzendorf Nicole G, Efverström Jonathan, Godec Ana, Sehlin Dag, Morrison Jamie, Hultqvist Greta

Imaging the pro‐coagulant state in Alzheimer’s Disease: Detection of fibrin and platelets accumulation in the brain by PET

利用PET成像技术检测阿尔茨海默病患者的促凝状态:脑内纤维蛋白和血小板聚集的检测

Elgendy, Islam Y; Gad, Mohamed M; Mansoor, Hend; Mahmoud, Ahmed N; Elbadawi, Ayman; Saad, Anas; Saad, Marwan; Elkaryoni, Ahmed; Secemsky, Eric A; Mamas, Mamas A; Monreal, Manuel; Weinberg, Ido; Pepine, Carl J; Soeterboek, Jens; Deckers, Kay; Backes, Walter H; Jansen, Jacobus FA; Schram, Miranda T; Bosma, Hans; Lakerveld, Jeroen; Sastry, Manu; Köhler, Sebastian; Lamanna‐Rama, Nicolás; Casquero‐Veiga, Marta; Ceron, Carlos; Sobrino, Gorka; Fernandez‐Nueda, Irene; Kossatz, Susanne; Sehlin, Dag; Desco, Manuel; Salinas, Beatriz; Cortes‐Canteli, Marta; Pelkmans, Wiesje; Shekari, Mahnaz; Escalante, Armand González; Kollmorgen, Gwendlyn; Quijano‐Rubio, Clara; Blennow, Kaj; Zetterberg, Henrik; Gispert, Juan Domingo; Suárez‐Calvet, Marc; Salvadó, Gemma; Casquero‐Veiga, Marta; Ceron, Carlos; Lamanna‐Rama, Nicolás; Fernandez‐Nueda, Irene; Rubio‐Retama, Jorge; Fuster, Valentin; Moro, Maria Angeles; Desco, Manuel; Herranz, Fernando; Salinas, Beatriz; Cortes‐Canteli, Marta

Comprehensive Approach for Sequential MALDI-MSI Analysis of Lipids, N-Glycans, and Peptides in Fresh-Frozen Rodent Brain Tissues

新鲜冷冻啮齿动物脑组织中脂质、N-糖和肽的序贯MALDI-MSI分析的综合方法

Lee, Yea-Rin; Kaya, Ibrahim; Wik, Elin; Baijnath, Sooraj; Lodén, Henrik; Nilsson, Anna; Zhang, Xiaoqun; Sehlin, Dag; Syvänen, Stina; Svenningsson, Per; Andrén, Per E

The effects of dose, valency, and affinity on TfR-mediated brain delivery in vivo

剂量、价态和亲和力对体内TfR介导的脑递送的影响

Bonvicini, Gillian; Singh, Sunitha; Sandersjöö, Lisa; Sehlin, Dag; Syvänen, Stina; Andersson, Ken G

High-affinity transferrin receptor binding improves brain delivery of bispecific antibodies at tracer dose.

高亲和力转铁蛋白受体结合可提高示踪剂量双特异性抗体向大脑的递送效率

Bonvicini Gillian, Singh Sunitha, Sandersjöö Lisa, Dallas Tiffany, Schlein Eva, Dahlén Amelia D, Lopes van den Broek Sara, Sehlin Dag, Andersson Ken G, Syvänen Stina