Phenotypic Screening Coupled with AI-Driven Target Deconvolution Identifies α-Terthienyl as a Dual DPP-IV/HSD17β13 Modulator with Efficacy in a Mouse Model of MASLD
表型筛选结合人工智能驱动的靶点解卷积,鉴定出α-三噻吩是一种双重DPP-IV/HSD17β13调节剂,在MASLD小鼠模型中具有疗效。
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doi:10.64898/2025.12.12.693988
Hoegeman, Kathryn M; Wotring, Jesse W; Fursmidt, Reid; Gaetz, Jedidiah; Khalil, Ehab M; Selinger, Douglas W; Kovalenko, Ilya; Schultz, Tracey L; McCarty, Sean M; O'Meara, Matthew J; Clasby, Martin C; Sexton, Jonathan Z