日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Classically activated macrophages undergo functionally significant nucleotide metabolism remodelling driven by nitric oxide

经典激活的巨噬细胞在硝酸的驱动下发生具有重要功能意义的核苷酸代谢重塑。

Steven V John ,Gretchen L Seim ,Billy J Erazo-Flores ,James A Votava ,Uzziah S Urquiza ,Nicholas L Arp ,John Steill ,Jack Freeman ,Lauren N Carnevale ,Isaiah Roberts ,Xin Qing ,Stuart A Lipton ,Ron Stewart ,Laura J Knoll ,Jing Fan

Single-Cell Patch-Clamp/Proteomics of Human Alzheimer's Disease iPSC-Derived Excitatory Neurons Versus Isogenic Wild-Type Controls Suggests Novel Causation and Therapeutic Targets

人类阿尔茨海默病 iPSC 衍生的兴奋性神经元与同源野生型对照的单细胞膜片钳/蛋白质组学表明了新的病因和治疗靶点

Swagata Ghatak, Jolene K Diedrich, Maria Talantova, Nivedita Bhadra, Henry Scott, Meetal Sharma, Matthew Albertolle, Nicholas J Schork, John R Yates 3rd, Stuart A Lipton

Metabolic Bypass Rescues Aberrant S-nitrosylation-Induced TCA Cycle Inhibition and Synapse Loss in Alzheimer's Disease Human Neurons

代谢旁路挽救了阿尔茨海默病人类神经元中异常的 S-亚硝化诱导的 TCA 循环抑制和突触丢失

Alexander Y Andreyev, Hongmei Yang, Paschalis-Thomas Doulias, Nima Dolatabadi, Xu Zhang, Melissa Luevanos, Mayra Blanco, Christine Baal, Ivan Putra, Tomohiro Nakamura, Harry Ischiropoulos, Steven R Tannenbaum, Stuart A Lipton

Targeted protein S-nitrosylation of ACE2 inhibits SARS-CoV-2 infection

ACE2蛋白的靶向S-亚硝基化可抑制SARS-CoV-2感染

Chang-Ki Oh ,Tomohiro Nakamura ,Nathan Beutler ,Xu Zhang ,Juan Piña-Crespo ,Maria Talantova ,Swagata Ghatak ,Dorit Trudler ,Lauren N Carnevale ,Scott R McKercher ,Malina A Bakowski ,Jolene K Diedrich ,Amanda J Roberts ,Ashley K Woods ,Victor Chi ,Anil K Gupta ,Mia A Rosenfeld ,Fiona L Kearns ,Lorenzo Casalino ,Namir Shaabani ,Hejun Liu ,Ian A Wilson ,Rommie E Amaro ,Dennis R Burton ,John R Yates 3rd ,Cyrus Becker ,Thomas F Rogers ,Arnab K Chatterjee ,Stuart A Lipton

S-Nitrosylation-mediated dysfunction of TCA cycle enzymes in synucleinopathy studied in postmortem human brains and hiPSC-derived neurons

在死后人类大脑和 hiPSC 衍生的神经元中研究了突触核蛋白病中 S-亚硝化介导的 TCA 循环酶功能障碍

Paschalis-Thomas Doulias, Hongmei Yang, Alexander Y Andreyev, Nima Dolatabadi, Henry Scott, Charlene K Raspur, Parth R Patel, Tomohiro Nakamura, Steven R Tannenbaum, Harry Ischiropoulos, Stuart A Lipton

S-Nitrosylation of cathepsin B affects autophagic flux and accumulation of protein aggregates in neurodegenerative disorders

组织蛋白酶B的S-亚硝基化影响自噬通量和神经退行性疾病中蛋白质聚集体的积累。

Ki-Ryeong Kim ,Eun-Jung Cho ,Jae-Won Eom ,Sang-Seok Oh ,Tomohiro Nakamura ,Chang-Ki Oh ,Stuart A Lipton ,Yang-Hee Kim

Mechanistic insight into female predominance in Alzheimer's disease based on aberrant protein S-nitrosylation of C3

基于C3蛋白异常S-亚硝基化的阿尔茨海默病女性高发机制研究

Hongmei Yang ,Chang-Ki Oh ,Haitham Amal ,John S Wishnok ,Sarah Lewis ,Emily Schahrer ,Dorit Trudler ,Tomohiro Nakamura ,Steven R Tannenbaum ,Stuart A Lipton

S-Nitrosylation of p62 Inhibits Autophagic Flux to Promote α-Synuclein Secretion and Spread in Parkinson's Disease and Lewy Body Dementia

p62 的 S-亚硝基化抑制自噬流,从而促进帕金森病和路易体痴呆中 α-突触核蛋白的分泌和扩散

Chang-Ki Oh ,Nima Dolatabadi ,Piotr Cieplak ,Maria T Diaz-Meco ,Jorge Moscat ,John P Nolan ,Tomohiro Nakamura ,Stuart A Lipton

Noncanonical transnitrosylation network contributes to synapse loss in Alzheimer's disease

非规范的亚硝基化网络导致阿尔茨海默病中的突触丢失

Tomohiro Nakamura #, Chang-Ki Oh #, Lujian Liao, Xu Zhang, Kevin M Lopez, Daniel Gibbs, Amanda K Deal, Henry R Scott, Brian Spencer, Eliezer Masliah, Robert A Rissman, John R Yates 3rd, Stuart A Lipton

Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation

二甲双胍通过抑制线粒体ATP和DNA合成,阻断NLRP3炎症小体的激活和肺部炎症。

Hongxu Xian ,Yuan Liu ,Alexandra Rundberg Nilsson ,Raphaella Gatchalian ,Timothy R Crother ,Warren G Tourtellotte ,Yi Zhang ,German R Aleman-Muench ,Gavin Lewis ,Weixuan Chen ,Sarah Kang ,Melissa Luevanos ,Dorit Trudler ,Stuart A Lipton ,Pejman Soroosh ,John Teijaro ,Juan Carlos de la Torre ,Moshe Arditi ,Michael Karin ,Elsa Sanchez-Lopez