日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A Potent Inhibitor of Caspase‑8 Based on the IL-18 Tetrapeptide Sequence Reveals Shared Specificities between Inflammatory and Apoptotic Initiator Caspases.

基于 IL-18 四肽序列的强效 Caspase-8 抑制剂揭示了炎症和凋亡起始 Caspase 之间的共同特异性

Bourne Christopher M, Raniszewski Nicole R, Mahale Ashutosh B, Kulkarni Madhura, Exconde Patrick M, Liu Sherry, Yost Winslow, Wrong Tristan J, Patio Robert C, Kardhashi Matilda, Shosanya Teni, Kambayashi Mirai, Discher Bohdana M, Brodsky Igor E, Burslem George M, Taabazuing Cornelius Y

Human non-canonical inflammasomes activate CASP3 to limit intracellular Salmonella replication in macrophages.

人类非经典炎症小体激活 CASP3 以限制巨噬细胞内沙门氏菌的复制。

Kulkarni Madhura, Bourne Christopher M, Mahale Ashutosh B, Exconde Patrick M, Murphy Cecelia, Cervantes Sofia, Kardhashi Matilda, Kambayashi Mirai, Yoo William, Wrong Tristan J, Patio Robert C, Discher Bohdana M, Taabazuing Cornelius Y

Chemical Tools Based on the Tetrapeptide Sequence of IL-18 Reveals Shared Specificities between Inflammatory and Apoptotic Initiator Caspases.

基于IL-18四肽序列的化学工具揭示了炎症和凋亡起始半胱天冬酶之间的共同特异性

Bourne Christopher M, Raniszewski Nicole R, Kulkarni Madhura, Exconde Patrick M, Liu Sherry, Yost Winslow, Wrong Tristan J, Patio Robert C, Mahale Ashutosh, Kardhashi Matilda, Shosanya Teni, Kambayashi Mirai, Discher Bohdana M, Brodsky Igor E, Burslem George M, Taabazuing Cornelius Y

Harnessing Pyroptosis for Cancer Immunotherapy

利用细胞焦亡进行癌症免疫治疗

Bourne, Christopher M; Taabazuing, Cornelius Y

The NLRP1 and CARD8 inflammasomes

NLRP1 和 CARD8 炎症小体

Taabazuing, Cornelius Y; Griswold, Andrew R; Bachovchin, Daniel A

DPP9's Enzymatic Activity and Not Its Binding to CARD8 Inhibits Inflammasome Activation

DPP9的酶活性而非其与CARD8的结合抑制炎症小体的激活

Griswold, Andrew R; Ball, Daniel P; Bhattacharjee, Abir; Chui, Ashley J; Rao, Sahana D; Taabazuing, Cornelius Y; Bachovchin, Daniel A

The facial triad in the α-ketoglutarate dependent oxygenase FIH: A role for sterics in linking substrate binding to O(2) activation

α-酮戊二酸依赖性加氧酶FIH中的面部三联体:空间位阻在连接底物结合和O₂活化中的作用

Hangasky, John A; Taabazuing, Cornelius Y; Martin, Cristina B; Eron, Scott J; Knapp, Michael J

Increased Turnover at Limiting O2 Concentrations by the Thr(387) → Ala Variant of HIF-Prolyl Hydroxylase PHD2

在氧气浓度受限的情况下,HIF-脯氨酰羟化酶PHD2的Thr(387)→Ala变体的周转率增加

Pektas, Serap; Taabazuing, Cornelius Y; Knapp, Michael J

Oxygen sensing strategies in mammals and bacteria

哺乳动物和细菌的氧感知策略

Taabazuing, Cornelius Y; Hangasky, John A; Knapp, Michael J

Imposing function down a (cupin)-barrel: secondary structure and metal stereochemistry in the αKG-dependent oxygenases

αKG依赖性加氧酶的二级结构和金属立体化学:杯状蛋白的功能

Hangasky, John A; Taabazuing, Cornelius Y; Valliere, Meaghan A; Knapp, Michael J