日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Patient-derived orthotopic xenograft models recapitulate the peritoneal dissemination of pancreatic cancer and delineate its transcriptional and regulatory programs

患者来源的原位异种移植模型重现了胰腺癌的腹膜播散，并阐明了其转录和调控程序。

期刊:Journal of Experimental & Clinical Cancer Research
影响因子:12.8
doi:10.1186/s13046-026-03668-9
Furukawa, Takaaki; Kumegawa, Kohei; Miyata, Kenichi; Takamatsu, Manabu; Iesato, Asumi; Saeki, Sumito; Yang, Liying; Shibata, Chikako; Takahara, Tomoko; Masuda, Kaoru; Mie, Takafumi; Okamoto, Takeshi; Takeda, Tsuyoshi; Sasaki, Takashi; Ozaka, Masato; Tanaka, Miwa; Takahashi, Shunji; Noda, Tetsuo; Yao, Ryoji; Sasahira, Naoki; Maruyama, Reo
信号转导
胰腺癌
肿瘤
肿瘤免疫
发表日期：2026
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BRAF(V600E) patient derived colon cancer organoids identify biomarkers of response to EGFR and BRAF inhibition and replicate clinical data

BRAF(V600E)患者来源的结肠癌类器官可识别EGFR和BRAF抑制剂疗效的生物标志物，并能重现临床数据。

期刊:Journal of Experimental & Clinical Cancer Research
影响因子:12.8
doi:10.1186/s13046-026-03699-2
Kotarac, Anna; Osumi, Hiroki; Malt, Alexander; Alp, Keziban Merve; Jarosch, Armin; Werner, Johannes; Benary, Manuela; Neumann, Christopher C M; Yao, Ryoji; Mertins, Philipp; Eils, Roland; Beule, Dieter; Sers, Christine; Keilholz, Ulrich; Ishaque, Naveed; Stintzing, Sebastian; Vecchione, Loredana
肿瘤
肠癌
肿瘤免疫
EGF
BRAF
EGFR
3D/类器官
发表日期：2026
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Ribosome biogenesis as a potential therapeutic target in KRAS mutant colorectal cancer.

核糖体生物合成作为KRAS突变型结直肠癌的潜在治疗靶点。

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-025-67979-9
Tanaka Yui, Sakahara Mizuho, Yamanaka Hitomi, Natsume Yasuko, Kusama Daisuke, Kumegawa Kohei, Yoshikawa Harunori, Abe Yuich, Okabayashi Koji, Matui Shimpei, Kitagawa Yuko, Koshikawa Naohiko, Osumi Hiroki, Shinozaki Eiji, Nagayama Satoshi, Adachi Jun, Maruyama Reo, Yao Ryoji
肠癌
肿瘤
RAS
发表日期：2025
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Integration of human inspection and artificial intelligence-based morphological typing of patient-derived organoids reveals interpatient heterogeneity of colorectal cancer

结合人工检查和基于人工智能的患者来源类器官形态学分型，揭示了结直肠癌患者间的异质性

期刊:Cancer Science
影响因子:4.3
doi:10.1111/cas.15396
Okamoto, Takuya; Natsume, Yasuko; Doi, Motomichi; Nosato, Hirokazu; Iwaki, Toshiyuki; Yamanaka, Hitomi; Yamamoto, Mayuko; Kawachi, Hiroshi; Noda, Tetsuo; Nagayama, Satoshi; Sakanashi, Hidenori; Yao, Ryoji
3D/类器官
肿瘤
肠癌
肿瘤免疫
发表日期：2022
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Evaluation of the RAS signaling network in response to MEK inhibition using organoids derived from a familial adenomatous polyposis patient

利用源自家族性腺瘤性息肉病患者的类器官评估 RAS 信号网络对 MEK 抑制的反应

期刊:Scientific Reports
影响因子:3.9
doi:10.1038/s41598-020-74530-x
Osumi, Hiroki; Muroi, Atsushi; Sakahara, Mizuho; Kawachi, Hiroshi; Okamoto, Takuya; Natsume, Yasuko; Yamanaka, Hitomi; Takano, Hiroshi; Kusama, Daisuke; Shinozaki, Eiji; Ooki, Akira; Yamaguchi, Kensei; Ueno, Masashi; Takeuchi, Kengo; Noda, Tetsuo; Nagayama, Satoshi; Koshikawa, Naohiko; Yao, Ryoji
3D/类器官
信号转导
RAS
免疫/内分泌
发表日期：2020
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MCRIP1 promotes the expression of lung-surfactant proteins in mice by disrupting CtBP-mediated epigenetic gene silencing

MCRIP1通过破坏CtBP介导的表观遗传基因沉默来促进小鼠肺表面活性蛋白的表达

期刊:Communications Biology
影响因子:5.1
doi:10.1038/s42003-019-0478-3
Weng, Jane S; Nakamura, Takanori; Moriizumi, Hisashi; Takano, Hiroshi; Yao, Ryoji; Takekawa, Mutsuhiro
MCR
RIP
表观遗传
发表日期：2019
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Odf2 haploinsufficiency causes a new type of decapitated and decaudated spermatozoa, Odf2-DDS, in mice.

Odf2 单倍体不足会导致小鼠出现一种新型的去头去尾精子，即 Odf2-DDS

期刊:Scientific Reports
影响因子:3.9
doi:10.1038/s41598-019-50516-2
Ito Chizuru, Akutsu Hidenori, Yao Ryoji, Yoshida Keiichi, Yamatoya Kenji, Mutoh Tohru, Makino Tsukasa, Aoyama Kazuhiro, Ishikawa Hiroaki, Kunimoto Koshi, Tsukita Sachiko, Noda Tetsuo, Kikkawa Masahide, Toshimori Kiyotaka
发育与干细胞
发表日期：2019
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Report on the use of non-clinical studies in the regulatory evaluation of oncology drugs

关于在肿瘤药物监管评估中使用非临床研究的报告

期刊:Cancer Science
影响因子:4.3
doi:10.1111/cas.12857
Hayakawa, Yoshihiro; Kawada, Manabu; Nishikawa, Hiroyoshi; Ochiya, Takahiro; Saya, Hideyuki; Seimiya, Hiroyuki; Yao, Ryoji; Hayashi, Masahiro; Kai, Chieko; Matsuda, Akira; Naoe, Tomoki; Ohtsu, Atsushi; Okazaki, Taku; Saji, Hideo; Sata, Masataka; Sugimura, Haruhiko; Sugiyama, Yuichi; Toi, Masakazu; Irimura, Tatsuro
肿瘤
肿瘤免疫
发表日期：2016
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JCA-AACR Joint Symposia in the 73rd Annual Meeting of the Japanese Cancer Association, Yokohama, 25-26 September 2014

日本癌症协会-美国癌症研究协会联合研讨会，日本癌症协会第73届年会，横滨，2014年9月25-26日

期刊:Cancer Science
影响因子:4.3
doi:10.1111/cas.12625
Yao, Ryoji; Mori, Seiichi; Noda, Tetsuo
肿瘤
肿瘤免疫
发表日期：2015
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TACC3 is required for the proper mitosis of sclerotome mesenchymal cells during formation of the axial skeleton

TACC3是轴骨形成过程中生骨节间充质细胞正常有丝分裂所必需的。

期刊:Cancer Science
影响因子:4.3
doi:10.1111/j.1349-7006.2007.00433.x
Yao, Ryoji; Natsume, Yasuko; Noda, Tetsuo
细胞生物学
发表日期：2007
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