【文献解析】慢性淋巴细胞白血病中临界免疫球蛋白重链可变区（IGHV）突变状态的预后价值：一项系统综述与荟萃分析
1. 领域背景与文献引入文献英文标题：Borderline IGHV mutational status defines a distinct subgroup of chronic lymphocytic leukemia with intermediate outcomes: a systematic review and meta-analysis；发表期刊：未明确提供；影响因子：未公开；研究领域：慢性淋巴细胞白血病预后标志物研究。慢性淋巴细胞白血病（
【文献解析】HDAC6抑制剂ACY-1215联合硼替佐米靶向NOTCH3驱动的T细胞急性淋巴细胞白血病
1. 领域背景与文献引入文献英文标题：ACY-1215, an HDAC6 inhibitor, in combination with bortezomib targets NOTCH3-driven T-cell acute lymphoblastic leukemia；发表期刊：未明确；影响因子：未公开；研究领域：T细胞急性淋巴细胞白血病（T-ALL）靶向治疗T细胞急性淋巴细胞白血病是一种侵袭性淋巴增殖性疾病，占儿童急
【文献解析】静脉溶栓24小时后血浆脂多糖水平作为急性缺血性脑卒中患者脑心综合征、卒中相关性肺炎及不良预后的潜在生物标志物——含LPS-T2的预测模型表现出稳健预测效能
1. 领域背景与文献文献英文标题：Plasma LPS level at 24 h after IVT serves as a potential biomarker for predicting CCS, SAP, and poor outcome in AIS patients, with the prediction models incorporating LPS‑T2 showing robust predictive performance.；发表期刊：未公开；影响因子：未公开；研究领域：急性缺血
【文献解析】LncRNA DLEU1通过ASCC2/ALKBH3-E2F1-G6PD轴调控胃癌的DNA修复与代谢适应
1. 领域背景与文献文献英文标题：LncRNA DLEU1 orchestrates DNA repair and metabolic adaptation via the ASCC2/ALKBH3-E2F1-G6PD axis in gastric cancer；发表期刊：Journal of Experimental & Clinical Cancer Research；影响因子：未公开；研究领域：胃癌分子机制、肿瘤DNA修复与代谢重编程。胃癌是全球范围内第五
【文献解析】基于蛋白质组学的宫颈癌分子分型及治疗靶点研究
1. 领域背景与文献文献英文标题：Proteome-based molecular classification of cervical cancer identifies subtype-specific therapeutic vulnerabilities；发表期刊：Journal of Experimental & Clinical Cancer Research；影响因子：未公开；研究领域：宫颈癌分子分型与精准治疗。宫颈癌是全球女性健康的主要恶性威胁
【文献解析】Spatial multi-omics reveals region-specific tumor microenvironment remodeling and therapeutic resistance mechanisms in hepatocellular carcinoma treated with lenvatinib, anti-PD-1, and radiotherapy
1. 领域背景与文献文献英文标题：Spatial multi-omics reveals region-specific tumor microenvironment remodeling and therapeutic resistance mechanisms in hepatocellular carcinoma treated with lenvatinib, anti-PD-1, and radiotherapy；发表期刊：Journal of Experimental & Clinical Cancer Research；影响因
【文献解析】癌症生物标志物的转录与表观遗传调控：整合肿瘤内在程序与免疫微环境的系统视角
1. 领域背景与文献引入文献英文标题：Transcriptional and epigenetic regulation of cancer biomarkers: a systems perspective integrating tumor-intrinsic programs and immune microenvironment；发表期刊：Journal of Experimental & Clinical Cancer Research；影响因子：11.3；研究领域：肿瘤学（癌症生物标志物
【文献解析】循环白细胞DNA甲基化特征预测子宫内膜异位症孕激素治疗反应
1. 领域背景与文献引入文献英文标题：Circulating leukocyte DNA methylation signatures predict progestin treatment response in endometriosis；发表期刊：Journal of Ovarian Research；影响因子：未公开；研究领域：妇科内分泌与生殖医学（子宫内膜异位症方向）。子宫内膜异位症是一种异质性、雌激素依赖性炎症性疾病
【文献解析】PARP inhibitors: clinical utility, mechanisms of resistance, and strategies to overcome resistance
1. 领域背景与文献引入文献英文标题：PARP inhibitors: clinical utility, mechanisms of resistance, and strategies to overcome resistance；发表期刊：Journal of Experimental & Clinical Cancer Research；影响因子：12.658；研究领域：肿瘤学，DNA损伤修复，精准医学。PARP抑制剂（PARPi）是基于“合成致死”原理
【文献解析】WFIKKN2：HER2阳性乳腺癌监测的新型循环生物标志物
1. 领域背景与文献文献英文标题：WFIKKN2 as a novel circulating biomarker for surveillance of HER2-positive breast cancer；发表期刊：BMC Cancer；影响因子：未公开；研究领域：肿瘤学-乳腺癌生物标志物研究领域共识：HER2阳性乳腺癌占所有乳腺癌的15%~20%，其复发风险显著高于其他乳腺癌亚型，尽管HER2靶向治疗的应用