【文献解析】一碳代谢关键氨基酸异常可能破坏癌症发展中的基因组稳定性
1. 领域背景与文献文献英文标题:The aberration of key amino acids participated one-carbon metabolism may jeopardize genetic stability in cancer development;发表期刊:Cell Communication and Signaling;影响因子:未公开;研究领域:肿瘤学(一碳代谢与基因组稳定性方向)一碳代谢是细胞内整合营养感知、代谢调
【文献解析】肿瘤代谢物2-羟基戊二酸通过降解CDH1调控细胞静止并增强化疗敏感性
1. 领域背景与文献文献英文标题:Oncometabolite 2-hydroxyglutarate destabilizes CDH1 to regulate quiescence and enhance chemotherapy sensitivity;发表期刊:Cell Communication and Signaling;影响因子:未公开;研究领域:肿瘤代谢调控与化疗增敏(涵盖神经胶质瘤、肺癌、结直肠癌等实体瘤)肿瘤代谢重编程是肿瘤
【文献解析】Mindin介导的αM整合素内吞激活STAT3维持角质形成细胞干性
1. 领域背景与文献文献英文标题:Mindin-mediated αM-integrin endocytosis activates STAT3 to maintain keratinocyte stemness;发表期刊:Cell Communication and Signaling;影响因子:未公开;研究领域:皮肤干细胞生物学、肿瘤干细胞调控、细胞信号转导领域共识:角质形成细胞干细胞是维持表皮稳态、驱动皮肤损伤修复
【文献解析】Co-targeting EGFR and SUCLG2 disrupts a nuclear transcriptional program driving neuroendocrine differentiation and TKI resistance in castration-resistant prostate cancer
1. 领域背景与文献文献英文标题:Co-targeting EGFR and SUCLG2 disrupts a nuclear transcriptional program driving neuroendocrine differentiation and TKI resistance in castration-resistant prostate cancer;发表期刊:Cell Communication and Signaling;影响因子:未公开;研究领域:泌尿生殖系统肿瘤(去势抵抗
【文献解析】蛋白精氨酸甲基转移酶5通过调控尿素循环维持肠道干细胞微环境稳态与再生
1. 领域背景与文献文献英文标题:Protein arginine methyltransferase 5 orchestrates the homeostasis and reconstitution of intestinal stem cell niche via balancing urea cycling;发表期刊:Cell Communication and Signaling;影响因子:未公开;研究领域:肠道干细胞生物学、辐射诱导肠损伤修复、蛋白翻译后修饰调
【文献解析】多组学与实验证据揭示caspase-8作为人软骨细胞中炎症、衰老及纤维化信号的非凋亡调控因子
1. 领域背景与文献文献英文标题:Multi-omics and experimental evidence in human chondrocytes identify caspase-8 as a non-apoptotic regulator of inflammatory, senescent, and fibrotic signaling in osteoarthritis;发表期刊:未公开;影响因子:未公开;研究领域:骨关节炎(OA)发病机制与靶向治疗骨关节炎是全球
【文献解析】幽门螺杆菌感染激活胃细胞中HIF-1α/ALS2/Rab5信号轴
1. 领域背景与文献文献英文标题:Helicobacter pylori infection activates the HIF-1α/ALS2/Rab5 signaling axis in gastric cells;发表期刊:Cell Communication and Signaling;影响因子:未公开;研究领域:肿瘤学-胃癌分子机制胃癌是全球范围内发病率和死亡率均位居前列的恶性肿瘤,幽门螺杆菌(Hp)感染是被世界卫生
【文献解析】NSCLC brain metastases exhibit reduced HLA-I antigen presentation machinery and immune evasion independent of IFNγ signaling defects
1. 领域背景与文献文献英文标题:NSCLC brain metastases exhibit reduced HLA-I antigen presentation machinery and immune evasion independent of IFNγ signaling defects;发表期刊:Molecular Cancer;影响因子:未公开;研究领域:肿瘤学-非小细胞肺癌脑转移免疫逃逸机制研究非小细胞肺癌(NSCLC)是全球发病率和死
【文献解析】靶向MORC2激活转座子介导的病毒模拟效应并增强三阴性乳腺癌免疫检查点阻断疗效
1. 领域背景与文献文献英文标题:Targeting MORC2 activates transposable element-mediated viral mimicry and potentiates immune checkpoint blockade in triple-negative breast cancer;发表期刊:Molecular Cancer(Mol Cancer);影响因子:未公开;研究领域:肿瘤学(三阴性乳腺癌免疫治疗与表观调控方向)三阴性乳
【文献解析】一种用于初级纤毛三通道成像的山羊来源γ-微管蛋白抗体
1. 领域背景与文献文献英文标题:A goat-derived gamma-tubulin antibody for triple-channel imaging of primary cilia;发表期刊:文献未明确提供;影响因子:文献未明确提供;研究领域:细胞生物学(初级纤毛研究、实验用抗体开发)领域共识:初级纤毛是存在于脊椎动物多种细胞表面的重要感觉细胞器,参与 Hedgehog 等多