【文献解析】Co-targeting EGFR and SUCLG2 disrupts a nuclear transcriptional program driving neuroendocrine differentiation and TKI resistance in castration-resistant prostate cancer
1. 领域背景与文献文献英文标题:Co-targeting EGFR and SUCLG2 disrupts a nuclear transcriptional program driving neuroendocrine differentiation and TKI resistance in castration-resistant prostate cancer;发表期刊:Cell Communication and Signaling;影响因子:未公开;研究领域:泌尿生殖系统肿瘤(去势抵抗
【文献解析】蛋白精氨酸甲基转移酶5通过调控尿素循环维持肠道干细胞微环境稳态与再生
1. 领域背景与文献文献英文标题:Protein arginine methyltransferase 5 orchestrates the homeostasis and reconstitution of intestinal stem cell niche via balancing urea cycling;发表期刊:Cell Communication and Signaling;影响因子:未公开;研究领域:肠道干细胞生物学、辐射诱导肠损伤修复、蛋白翻译后修饰调
【文献解析】多组学与实验证据揭示caspase-8作为人软骨细胞中炎症、衰老及纤维化信号的非凋亡调控因子
1. 领域背景与文献文献英文标题:Multi-omics and experimental evidence in human chondrocytes identify caspase-8 as a non-apoptotic regulator of inflammatory, senescent, and fibrotic signaling in osteoarthritis;发表期刊:未公开;影响因子:未公开;研究领域:骨关节炎(OA)发病机制与靶向治疗骨关节炎是全球
【文献解析】幽门螺杆菌感染激活胃细胞中HIF-1α/ALS2/Rab5信号轴
1. 领域背景与文献文献英文标题:Helicobacter pylori infection activates the HIF-1α/ALS2/Rab5 signaling axis in gastric cells;发表期刊:Cell Communication and Signaling;影响因子:未公开;研究领域:肿瘤学-胃癌分子机制胃癌是全球范围内发病率和死亡率均位居前列的恶性肿瘤,幽门螺杆菌(Hp)感染是被世界卫生
【文献解析】COVID-19与复发性流产患者调节性B细胞表观遗传失调的关联
1. 领域背景与文献文献英文标题:COVID-19 is associated with epigenetic dysregulation in regulatory B cells linked to recurrent pregnancy loss;发表期刊:Cell Communication and Signaling;影响因子:未公开;研究领域:生殖免疫学、表观遗传学交叉领域复发性流产(RPL)影响1-2%的育龄女性,约半数病例病因不明,
【文献解析】Raw:一种与dSarm协同调控发育和轴突退化的TIR折叠cADPR水解酶
1. 领域背景与文献文献英文标题:Raw defines a TIR-fold cADPR hydrolase cooperating with dSarm in development and axon degeneration;发表期刊:Cell Communication and Signaling;影响因子:8.9(2024);研究领域:细胞信号传导、神经生物学(轴突退化调控)、发育生物学领域共识:TIR(Toll/interleukin-1 recept
【文献解析】解码TNF受体超家族对CD4+Foxp3+调节性T细胞介导耐受的调控:对移植物抗宿主病治疗的启示
1. 领域背景与文献文献英文标题:Decoding TNF receptor superfamily control of CD4+Foxp3+ Regulatory T cell-mediated tolerance: implications for the treatment of graft‑versus‑host disease;发表期刊:Cell Communication and Signaling;影响因子:未公开;研究领域:移植免疫学、肿瘤免疫学异基因造血干细胞移
【文献解析】Neddylation blockade protects endothelial cells against inflammation and ischemia-reperfusion injuries
1. 领域背景与文献文献英文标题:Neddylation blockade protects endothelial cells against inflammation and ischemia-reperfusion injuries;发表期刊:Cell Commun Signal;影响因子:未公开;研究领域:器官移植与缺血再灌注损伤(移植免疫学、血管生物学)器官移植是终末期器官衰竭患者的有效治疗方案,但慢性移植物功
【文献解析】鼠伤寒沙门氏菌劫持宿主葡萄糖转运蛋白以支持胞内增殖
1. 领域背景与文献文献英文标题:Salmonella Typhimurium hijacks a host glucose transporter for intravacuolar proliferation;发表期刊:Cell Communication and Signaling;影响因子:未公开;研究领域:感染免疫、胞内细菌致病机制、宿主代谢调控胞内寄生菌是一类能侵入宿主细胞并在胞内微环境中完成生存、增殖周期的
【文献解析】与信号惰性TLR8b异源二聚化将草鱼TLR8a从促病毒传感器转变为抗病毒传感器
1. 领域背景与文献文献英文标题:Heterodimerization with signaling-inert TLR8b converts TLR8a from proviral to antiviral sensor in Ctenopharyngodon idella;发表期刊:Cell Communication and Signaling;影响因子:8.9(2024);研究领域:鱼类先天免疫、Toll样受体(TLR)进化与功能调控Toll样受体(TLR)是先天免