ACSL4/FACL4 Polyclonal antibody (22401-1-AP)
ACSL4; FACL4; ACS4; ACSL 4; Arachidonate--CoA ligase
用户验证的应用
经验证应用
| 项目 | 详情 |
|---|---|
| Positive WB detected in | BV-2 cells, HEK-293 cells, HeLa cells, HepG2 cells, COLO 320 cells, NIH/3T3 cells, mouse kidney tissue, rat kidney tissue, RAW 264.7 cells |
| Positive IP detected in | HEK-293 cells |
| Positive IHC detected in | mouse brain tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
推荐稀释说明
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. Sample-dependent, Check data in validation data gallery.
详细信息
背景信息
Acyl-CoA synthetase long-chain family member 4 (Acsl4), an important enzyme involved in lipid metabolism, participates in ferroptosis by converting free AA into arachidonoyl-CoA to generate lipid hydroperoxides. Recent studies revealed that ACSL4 is involved in biological responses including inflammation, steroidogenesis, cell death, female fertility, and cancer. Acsl4 has two isoforms: 79 kDa and 75 kDa. ACSL4 also can be detected in 70 kDa(PMID:35326233).
文献引用 (145)
Bio-barrier-adaptable biomimetic nanomedicines combined with ultrasound for enhanced cancer therapy.
生物屏障适应性仿生纳米药物与超声波结合，可增强癌症治疗效果
Redox regulation of TRIM28 facilitates neuronal ferroptosis by promoting SUMOylation and inhibiting OPTN-selective autophagic degradation of ACSL4.
TRIM28 的氧化还原调控通过促进 SUMO 化和抑制 OPTN 选择性自噬降解 ACSL4 来促进神经元铁死亡
Injectable ECM-mimetic dynamic hydrogels abolish ferroptosis-induced post-discectomy herniation through delivering nucleus pulposus progenitor cell-derived exosomes
可注射的 ECM 模拟动态水凝胶通过递送髓核祖细胞衍生的外泌体来消除铁死亡诱导的椎间盘切除术后疝。
Attenuated growth factor signaling during cell death initiation sensitizes membranes towards peroxidation
细胞死亡启动过程中生长因子信号减弱使膜对过氧化敏感
Palmitoylation-dependent regulation of GPX4 suppresses ferroptosis
棕榈酰化依赖的GPX4调节抑制铁死亡
Elevated Histone Lactylation Mediates Ferroptosis Resistance in Endometriosis Through the METTL3-Regulated HIF1A/HMOX1 Signaling Pathway.
组蛋白乳化水平升高通过 METTL3 调控的 HIF1A/HMOX1 信号通路介导子宫内膜异位症中的铁死亡抵抗
Inhibition of Ferroptosis Delays Aging and Extends Healthspan Across Multiple Species.
抑制铁死亡可延缓衰老并延长多种物种的健康寿命
Lactiplantibacillus plantarum -derived extracellular vesicles alleviate acute lung injury by inhibiting ferroptosis of macrophages.
植物乳杆菌衍生的细胞外囊泡通过抑制巨噬细胞的铁死亡来减轻急性肺损伤
A decrease in Flavonifractor plautii and its product, phytosphingosine, predisposes individuals with phlegm-dampness constitution to metabolic disorders.
黄酮类化合物及其产物植物鞘氨醇的减少，使痰湿体质的人容易发生代谢紊乱
A CD147-targeted small-molecule inhibitor potentiates gemcitabine efficacy by triggering ferroptosis in pancreatic ductal adenocarcinoma
CD147靶向小分子抑制剂通过诱导胰腺导管腺癌中的铁死亡来增强吉西他滨的疗效
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