用户验证的应用
经验证应用
| 项目 | 详情 |
|---|---|
| Positive WB detected in | HEK-293T cells, Calyculin A treated HEK-293T cells, UV treated HEK-293T cells, UV treated NIH/3T3 cells, Anisomycin treated NIH/3T3 cells |
| Positive IF/ICC detected in | UV treated HEK-293 cells |
| Positive FC (Intra) detected in | Calyculin A treated HEK-293 cells |
推荐稀释比例
- Western Blot (WB)1:1000-1:4000
- Immunofluorescence (IF)/ICC1:200-1:800
- Flow Cytometry (FC) (INTRA)0.13 ug per 10^6 cells in a 100 µl suspension
推荐稀释说明
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. Sample-dependent, Check data in validation data gallery.
详细信息
背景信息
MAPK8(Mitogen-activated protein kinase 8) is also named as JNK1, PRKM8, SAPK1, SAPK1C and belongs to the MAP kinase subfamily. The JNK gene generates 10 forms of JNK through alternative splicing, and the protein encoded by the JNK gene has or does not have a COOH terminal, resulting in 46 kDa and 54 kDa proteins. MAPK8 is activated by dual phosphorylation at a Thr-Pro-Tyr motif during response to UV light. Phosphorylation of these sites in response to UV results in transcriptional activation of c-Jun. In the phosphorylation of JNK, JNK1 and JNK2/3 have molecular weights of 46 and 54 kDa(PMID: 21378396)
文献引用 (78)
Free fatty acid receptor-4 regulates T-cell-mediated allogeneic reaction through activating an aryl hydrocarbon receptor pathway
游离脂肪酸受体-4通过激活芳烃受体通路调节T细胞介导的同种异体反应。
Gut Microbiota Modulates Obesity-Associated Skeletal Deterioration Through Macrophage Aging and Grancalcin Secretion.
肠道菌群通过巨噬细胞衰老和颗粒钙蛋白分泌调节肥胖相关的骨骼退化
4-Octyl Itaconate Alleviates Myocardial Ischemia-Reperfusion Injury Through Promoting Angiogenesis via ERK Signaling Activation.
4-辛基衣康酸酯通过激活ERK信号促进血管生成，从而减轻心肌缺血再灌注损伤
Mannose-Glycated Metal-Phenolic Microcapsules Orchestrate Phenotype Switch of Macrophages for Boosting Tumor Immunotherapy.
甘露糖基化金属酚类微胶囊调控巨噬细胞表型转换以增强肿瘤免疫疗法
FNDC5/irisin-enriched sEVs conjugated with bone-targeting aptamer alleviate osteoporosis: a potential alternative to exercise.
富含 FNDC5/irisin 的 sEV 与骨靶向适体结合可缓解骨质疏松症：一种潜在的运动替代方案
PINK1 modulates Prdx2 to reduce lipotoxicity-induced apoptosis and attenuate cardiac dysfunction in heart failure mice with a preserved ejection fraction.
PINK1 调节 Prdx2 以减少脂毒性诱导的细胞凋亡，并减轻射血分数保留的心力衰竭小鼠的心脏功能障碍
Enhancing pancreatic cancer treatment: the role of H101 oncolytic virus in irreversible electroporation.
增强胰腺癌治疗：H101溶瘤病毒在不可逆电穿孔中的作用
Protective effects of Notoginsenoside R2 on reducing lipid accumulation and mitochondrial dysfunction in diabetic nephropathy through regulation of c-Src
三七皂苷R2通过调节c-Src减少糖尿病肾病脂质沉积和线粒体功能障碍的保护作用
Sophoridine inhibits proliferation and migration by targeting PIM1 in breast cancer.
槐定通过靶向乳腺癌细胞中的 PIM1 来抑制其增殖和迁移
Gut microbiota derived metabolite trimethylamine N-oxide influences prostate cancer progression via the p38/HMOX1 pathway
肠道微生物衍生的代谢物三甲胺 N-氧化物通过 p38/HMOX1 通路影响前列腺癌进展
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