用户验证的应用
经验证应用
| 项目 | 详情 |
|---|---|
| Positive WB detected in | bEnd.3 cells, mouse liver tissue, mouse spleen tissue |
| Positive IHC detected in | mouse liver tissue, mouse brain tissue, mouse kidney tissue, mouse spleen tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Positive IF-P detected in | mouse brain tissue, mouse kidney tissue |
| Positive IF-Fro detected in | mouse brain tissue |
推荐稀释说明
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. Sample-dependent, Check data in validation data gallery.
详细信息
背景信息
Platelet endothelial cell adhesion molecule-1 (PECAM-1, CD31) is a member of the immunoglobulin gene superfamily of cell adhesion molecules. CD31 is a transmembrane glycoprotein that is highly expressed on the surface of the endothelium, making up a large portion of its intracellular junctions. PECAM-1 is also present on the surface of hematopoietic cells and immune cells including platelets, monocytes, neutrophils, natural killer cells, megakaryocytes and some types of T-cell (PMID: 9011572). As well as its role in cell-cell adhesion, PECAM-1 functions as a signaling receptor, and is involved in important physiological events such as nitric oxide production, regulation of T-cell immunity and tolerance, leukocyte transendothelial migration and inflammation and angiogenesis (PMID: 21183735; 20978210; 17872453; 20634489).
文献引用 (71)
Evenly Distributed Microporous Structure and E7 Peptide Functionalization Synergistically Accelerate Osteogenesis and Angiogenesis in Engineered Periosteum.
均匀分布的微孔结构和 E7 肽功能化协同加速工程化骨膜的成骨和血管生成
A natural small molecule isoginkgetin alleviates hypercholesterolemia and atherosclerosis by targeting ACLY.
天然小分子异银杏黄素通过靶向ACLY缓解高胆固醇血症和动脉粥样硬化
Dominant follicle-targeted nanocarriers for GH delivery to alleviate premature ovarian insufficiency.
以优势卵泡为靶点的纳米载体用于输送生长激素，以缓解卵巢早衰
Targeting capture and eradicate circulating tumor cells by activated platelet derived vehicle for inhibiting triple-negative breast cancer metastasis.
利用活化血小板衍生的载体靶向捕获和清除循环肿瘤细胞，以抑制三阴性乳腺癌转移
Elastin-like polypeptide and triclosan-modified PCL membrane provides aseptic protection in tissue regeneration.
弹性蛋白样多肽和三氯生修饰的PCL膜在组织再生中提供无菌保护
Self-assembled extracellular matrix-lipid nanoparticle composite for site-specific siRNA delivery to improve cardiac repair post-myocardial infarction.
自组装细胞外基质-脂质纳米颗粒复合材料用于定点siRNA递送，以改善心肌梗死后的心脏修复
Notch1 signaling regulates Sox9 and VEGFA expression and governs BMP2-induced endochondral ossification of mesenchymal stem cells.
Notch1 信号调节 Sox9 和 VEGFA 的表达，并控制 BMP2 诱导的间充质干细胞的软骨内成骨
Polygonati Rhizoma Prevents Glucocorticoid-Induced Growth Inhibition of Muscle via Promoting Muscle Angiogenesis Through Deoxycholic Acid.
虎杖通过脱氧胆酸促进肌肉血管生成，从而防止糖皮质激素引起的肌肉生长抑制
LDHA-mediated glycolysis in stria vascularis endothelial cells regulates macrophages function through CX3CL1-CX3CR1 pathway in noise-induced oxidative stress
噪声诱导的氧化应激中血管纹内皮细胞LDHA介导的糖酵解通过CX3CL1-CX3CR1通路调节巨噬细胞功能
Exosomes containing miR-152-3p targeting FGFR3 mediate SLC7A7-induced angiogenesis in bladder cancer.
含有靶向 FGFR3 的 miR-152-3p 的外泌体介导 SLC7A7 诱导的膀胱癌血管生成
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