Global, regional, and national burden of headache disorders, 1990-2021, with forecasts to 2050: A Global Burden of Disease study 2021

1990-2021年全球、区域和国家头痛疾病负担及至2050年预测：2021年全球疾病负担研究

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作者：Wijeratne,Tissa,Oh,Jiyeon,Kim,Soeun,Yim,Yesol,Kim,Min Seo,Shin,Jae Il,Oh,Yun-Seo,Jung,Raon,Kim,Yun Seo,Smith,Lee,Aalruz,Hasan,Abd-Rabu,Rami,Abdulah,Deldar Morad,Aboagye,Richard Gyan,Abolmaali,Meysam,Abtahi,Dariush,Abualhasan,Ahmed,Adedoyin,Rufus Adesoji,Adnani,Qorinah Estiningtyas Sakilah,Afrashteh,Fatemeh,Aggarwal,Navidha,Ahmad,Danish,Ahmadi,Ali,Ahmadi,Negar Sadat,Ahmadzade,Amir Mahmoud,Ahmed,Syed Anees,Al Awaidy,Salah,Alabbad,Sawsan,Alajlani,Muaaz M,Al-Ajlouni,Yazan,Ali,Mohammed Usman,Ali,Syed Shujait,Ali,Waad,Almazan,Joseph Uy,Alshahrani,Najim Z,Altaf,Awais,Al-Wardat,Mohammad,Alzoubi,Karem H,Amiri,Sohrab,Amu,Hubert,Amusa,Ganiyu Adeniyi,Anderson,David B,Anwar,Saleha,Areda,Demelash,Asghari-Jafarabadi,Mohammad,Ashina,Sait,Ashraf,Javed,Ashraf,Tahira,Azargoonjahromi,Ali,Bahurupi,Yogesh,Baig,Atif Amin,Bandyopadhyay,Soham,Bardhan,Mainak,Barqawi,Hiba Jawdat,Bashiri,Azadeh,Bastan,Mohammad-Mahdi,Bemanalizadeh,Maryam,Bensenor,Isabela M,Berhie,Alemshet Yirga Yirga,Bhagavathula,Akshaya Srikanth,Bhaskar,Sonu,Bhat,Vivek,Bhatti,Gurjit Kaur,Bhatti,Jasvinder Singh,Bilgin,Cem,Biswas,Atanu,Bizzozero-Peroni,Bruno,Bustanji,Yasser,Cámera,Luis Alberto,Caronna,Edoardo,Carvalho,Andre F,Chakraborty,Sandip,Ching,Patrick R,Christodoulou,Nikos,Chu,Dinh-Toi,Chu,Hongyuan,Cruz-Martins,Natalia,Dadras,Omid,Dai,Xiaochen,D'Amico,Emanuele,Darwish,Amira Hamed,Deekonda,Sindhura,Devanbu,Vinoth Gnana Chellaiyan,Dharmaratne,Samath Dhamminda,Dima,Adriana,Dinkayehu,Temesgien Ergetie,Do,Huyen,Doku,Paul Narh,Doshi,Ojas Prakashbhai,E'mar,Abdel Rahman,Eissazade,Negin,Eltaha,Chadi,Fahim,Ayesha,Fares,Jawad,Farjoud Kouhanjani,Mohsen,Faro,Andre,Fazeli,Patrick,Fereshtehnejad,Seyed-Mohammad,Ferrara,Pietro,Ferreira,Nuno,Fischer,Florian,Fornari,Arianna,Gajdács,Márió,Gebregergis,Miglas Welay,Ghadimi,Delaram J,Ghaffari Jolfayi,Amir,Gnedovskaya,Elena V,Golechha,Mahaveer,Gomez Figueroa,Enrique,Hashempur,Mohammad Hashem,Hasnain,Md Saquib,Hassan,Amr,Hassan,Nageeb,Hassan Zadeh Tabatabaei,Mahgol Sadat,Hegazy,Mohamed I,Heidari,Golnaz,Helfer,Bartosz,Hossain,Md Mahbub,Househ,Mowafa,Hu,Chengxi,Iavicoli,Ivo,Ilesanmi,Olayinka Stephen,Ilic,Irena M,Ilyas,Muhana Fawwazy,Ilyasu,Salim,Ismail,Nahlah Elkudssiah,Jafari-Khounigh,Ali,Jahrami,Haitham,Janodia,Manthan Dilipkumar,Jayasinghe,Ruwan Duminda,Jeswani,Bijay Mukesh,Jonas,Jost B,Joseph,Nitin,Kalani,Rizwan,Khan,Moien A B,Khateri,Sorour,Khatib,Mahalaqua Nazli,Khayat Kashani,Hamid Reza,Khidri,Feriha Fatima,Khormali,Moein,Khosravi,Sepehr,Kim,Yun Jin,Kompani,Farzad,Kostev,Karel,Krishan,Kewal,Krishnan,Bindu,Defo,Barthelemy Kuate,Kuddus,Mohammed,Kulimbet,Mukhtar,Kumar,Rakesh,Kumar,Vijay,Kytö,Ville,Lasrado,Savita,Lee,Seung Won,Lenzi,Jacopo,Leonardi,Matilde,Lucchetti,Giancarlo,Lugo,Alessandra,Makhdoom,Irsa Fatima,Mallahzadeh,Arashk,Mansouri,Vahid,Marzo,Roy Rillera,Mathangasinghe,Yasith,Mayeli,Mahsa,Mehmood,Asim,Meretoja,Atte,Mestrovic,Tomislav,Mettananda,Sachith,Minervini,Giuseppe,Mishra,Archana,Mithra,Prasanna,Mohamed Ahmed,Khabab Abbasher Hussien,Mohammadzadeh,Ibrahim,Mohammed,Shafiu,Monasta,Lorenzo,Morrison,Shane Douglas,Nabavi,Amin,Natto,Zuhair S,Nauman,Javaid,Nieddu,Luciano,Nugen,Fred,Olagunju,Andrew T,Oliveira,Arão Belitardo,Oliveira,Welber Sousa,Omar,Hany A,Omer,Goran Latif,Otstavnov,Nikita,P A,Mahesh,Panos,Leonidas D,Parikh,Romil R,Patil,Shankargouda,Patra,Apurba,Pedersini,Paolo,Pensato,Umberto,Peprah,Prince,Peres,Mario F P,Piradov,Michael A,Pozo-Rosich,Patricia,Pradhan,Jalandhar,Prakash,Sanjay,Prashant,Akila,Puvvula,Jagadeesh,Rafiei,Alireza,Raggi,Alberto,Rahmani,Amir Masoud,Ramadan,Mahmoud Mohammed,Rathish,Devarajan,Rautalin,Ilari,Rawaf,Salman,Rezaeian,Mohsen,Rezazadeh Eidgahi,Donya,Rhee,Taeho Gregory,Roy,Priyanka,Saad Eddin,Adnan,Sabet,Cameron John,Saddik,Basema Ahmad,Sadeghi,Erfan,Saeed,Umar,Saheb Sharif-Askari,Fatemeh,Saheb Sharif-Askari,Narjes,Sahoo,Pragyan Monalisa,Salimi,Sohrab,Samy,Abdallah M,Saulam,Jennifer,Sawhney,Monika,Senol,Yigit Can,Senthilkumaran,Subramanian,Sethi,Yashendra,Seyedmirzaei,Homa,Shafie,Mahan,Shamsi,Anas,Sharifan,Amin,Shehata,Hatem Samir,Shenoy,Rekha Raghuveer,Shokraneh,Farhad,Sidhu,Jaspreet Kaur,Singh,Baljinder,Singh,Harmanjit,Singh,Jasvinder A,Singh,Surjit,Skryabina,Anna Aleksandrovna,Sobia,Farrukh,Srichawla,Bahadar S,Suresh,Vinay,Swain,Chandan Kumar,T Y,Sree Sudha,Tabaee Damavandi,Payam,Tabche,Celine,Tabish,Mohammad,Tanwar,Manoj,Temsah,Mohamad-Hani,Teramoto,Masayuki,Tran,Nghia Minh,Tran,Thang Huu,Tsatsakis,Aristidis,Udoakang,Aniefiok John,Usman,Jibrin Sammani,Uzunçıbuk,Hande,Van den Eynde,Jef,Vasankari,Tommi Juhani,Venketasubramanian,Narayanaswamy,Villafañe,Jorge Hugo,Wang,Lintao,Wang,Xingxin,Wang,Yuan-Pang,Wiangkham,Taweewat,Winkler,Andrea Sylvia,Wollie,Alemayehu Molla,Xiao,Zheman,Yismaw,Yazachew Engida Engida,Yousuf,Abdilahi,Zhao,Zhongyi,Zielińska,Magdalena,Chu,Min Kyung,Song,Tae-Jin,Yon,Dong Keon,Feigin,Valery L
期刊：Cell Reports Medicine影响因子：
时间：2025起止号：2025 Oct 21;6(10)：102348
doi：10.1016/j.xcrm.2025.102348

Abstract

Headache disorders, especially migraines and tension-type headaches (TTHs), are major global public health concerns, as shown by the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021. We provide updated global estimates of prevalence and years lived with disability (YLDs) from 1990 to 2021 across 204 countries and territories and forecasts through 2050. In 2021, there are 2.0 billion people with TTH and 1.2 billion with migraine. Although TTH is more prevalent, migraine causes higher disability. While crude prevalence and YLDs increased, age-standardized rates remained stable and are projected to continue this trend due to population growth. There is a disproportionately higher burden in women aged 30-44 and countries with higher Socio-demographic Index and Healthcare Access and Quality Index. Despite this, migraines remain underrecognized in health policies and funding. This study emphasizes the urgent need to prioritize headache disorders in global health agendas.

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