Alpha smooth muscle actin specific Polyclonal antibody (55135-1-AP)
ACTA2; Alpha SMA; a-SMA; smooth muscle actin; a SMA
用户验证的应用
经验证应用
| 项目 | 详情 |
|---|---|
| Positive WB detected in | mouse colon tissue, mouse kidney tissue, mouse stomach, rat colon, mouse lung, rat lung |
| Positive IHC detected in | mouse heart tissue, human colon tissue, human colon cancer tissue, human heart tissue, human hepatocirrhosis tissue, human liver cancer tissue, mouse colon tissue, mouse liver tissue, rat colon tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Positive IF-P detected in | mouse heart tissue |
推荐稀释说明
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. Sample-dependent, Check data in validation data gallery.
详细信息
背景信息
ACTA2, also named as a-SMA,AAT6;ACTSA belongs to the actin family. Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Defects in ACTA2 are the cause of aortic aneurysm familial thoracic type 6 (AAT6). The immunogen of this antibody is a specific domain of ACTA2. This antibody stains the aorta only.
文献引用 (105)
Semaphorin 3E-Plexin D1 Axis Drives Lung Fibrosis through ErbB2-Mediated Fibroblast Activation.
Semaphorin 3E-Plexin D1 轴通过 ErbB2 介导的成纤维细胞活化驱动肺纤维化
LIMA1 O-GlcNAcylation Promotes Hepatic Lipid Deposition through Inducing β-catenin-Regulated FASn Expression in Metabolic Dysfunction-Associated Steatotic Liver Disease.
LIMA1 O-GlcNAc糖基化通过诱导β-catenin调节的FASN表达促进代谢功能障碍相关脂肪肝疾病中的肝脏脂质沉积
Cancer-associated fibroblasts secrete CSF3 to promote TNBC progression via enhancing PGM2L1-dependent glycolysis reprogramming
癌症相关成纤维细胞分泌CSF3，通过增强PGM2L1依赖性糖酵解重编程促进TNBC进展
Hepatic Stellate Cell TM4SF1 Accelerates Hepatic Fibrosis Progression via Interacting With the Tyrosine Kinase c-Src.
肝星状细胞 TM4SF1 通过与酪氨酸激酶 c-Src 相互作用加速肝纤维化进展
Formation of neutrophil extracellular traps in the early stages exacerbate the healing process by regulating macrophage polarization in Achilles tendon-bone injury
中性粒细胞胞外陷阱在早期阶段的形成，通过调节巨噬细胞极化，加剧跟腱骨损伤的愈合过程。
Mechanical stress contributes to ligamentum flavum hypertrophy by inducing local inflammation and myofibroblast transition in the innovative surgical rabbit model
在创新的兔外科模型中，机械应力通过诱导局部炎症和肌成纤维细胞转化，导致黄韧带肥大。
Monotropein inhibits epithelial-mesenchymal transition in chronic colitis via the mTOR/P70S6K pathway.
单核细胞增生素通过 mTOR/P70S6K 通路抑制慢性结肠炎中的上皮-间质转化
Epac1 Inhibits Orbital Fibroblast Activation to Ameliorate Thyroid-Associated Orbitopathy-Like Features Through the JAK/STAT Signaling Pathway.
Epac1 通过 JAK/STAT 信号通路抑制眼眶成纤维细胞活化，从而改善甲状腺相关眼病样特征
MicroRNA-122-5p is upregulated in diabetic foot ulcers and decelerates the transition from the inflammatory to the proliferative stage.
MicroRNA-122-5p 在糖尿病足溃疡中上调，减缓从炎症期到增殖期的转变
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