Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids

一项针对387272名个体的多民族全基因组基因-吸烟相互作用研究发现了与血脂相关的新基因位点

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作者：Bentley,Amy R,Sung,Yun J,Brown,Michael R,Winkler,Thomas W,Kraja,Aldi T,Ntalla,Ioanna,Schwander,Karen,Chasman,Daniel I,Lim,Elise,Deng,Xuan,Guo,Xiuqing,Liu,Jingmin,Lu,Yingchang,Cheng,Ching-Yu,Sim,Xueling,Vojinovic,Dina,Huffman,Jennifer E,Musani,Solomon K,Li,Changwei,Feitosa,Mary F,Richard,Melissa A,Noordam,Raymond,Baker,Jenna,Chen,Guanjie,Aschard,Hugues,Bartz,Traci M,Ding,Jingzhong,Dorajoo,Rajkumar,Manning,Alisa K,Rankinen,Tuomo,Smith,Albert V,Tajuddin,Salman M,Zhao,Wei,Graff,Mariaelisa,Alver,Maris,Boissel,Mathilde,Chai,Jin Fang,Chen,Xu,Divers,Jasmin,Evangelou,Evangelos,Gao,Chuan,Goel,Anuj,Hagemeijer,Yanick,Harris,Sarah E,Hartwig,Fernando P,He,Meian,Horimoto,Andrea R V R,Hsu,Fang-Chi,Hung,Yi-Jen,Jackson,Anne U,Kasturiratne,Anuradhani,Komulainen,Pirjo,Kühnel,Brigitte,Leander,Karin,Lin,Keng-Hung,Luan,Jian'an,Lyytikäinen,Leo-Pekka,Matoba,Nana,Nolte,Ilja M,Pietzner,Maik,Prins,Bram,Riaz,Muhammad,Robino,Antonietta,Said,M Abdullah,Schupf,Nicole,Scott,Robert A,Sofer,Tamar,Stancáková,Alena,Takeuchi,Fumihiko,Tayo,Bamidele O,van der Most,Peter J,Varga,Tibor V,Wang,Tzung-Dau,Wang,Yajuan,Ware,Erin B,Wen,Wanqing,Xiang,Yong-Bing,Yanek,Lisa R,Zhang,Weihua,Zhao,Jing Hua,Adeyemo,Adebowale,Afaq,Saima,Amin,Najaf,Amini,Marzyeh,Arking,Dan E,Arzumanyan,Zorayr,Aung,Tin,Ballantyne,Christie,Barr,R Graham,Bielak,Lawrence F,Boerwinkle,Eric,Bottinger,Erwin P,Broeckel,Ulrich,Brown,Morris,Cade,Brian E,Campbell,Archie,Canouil,Mickaël,Charumathi,Sabanayagam,Chen,Yii-Der Ida,Christensen,Kaare,Concas,Maria Pina,Connell,John M,de las Fuentes,Lisa,de Silva,H Janaka,de Vries,Paul S,Doumatey,Ayo,Duan,Qing,Eaton,Charles B,Eppinga,Ruben N,Faul,Jessica D,Floyd,James S,Forouhi,Nita G,Forrester,Terrence,Friedlander,Yechiel,Gandin,Ilaria,Gao,He,Ghanbari,Mohsen,Gharib,Sina A,Gigante,Bruna,Giulianini,Franco,Grabe,Hans J,Gu,C Charles,Harris,Tamara B,Heikkinen,Sami,Heng,Chew-Kiat,Hirata,Makoto,Hixson,James E,Ikram,M Arfan,Jia,Yucheng,Joehanes,Roby,Johnson,Craig,Jonas,Jost Bruno,Justice,Anne E,Katsuya,Tomohiro,Khor,Chiea Chuen,Kilpeläinen,Tuomas O,Koh,Woon-Puay,Kolcic,Ivana,Kooperberg,Charles,Krieger,Jose E,Kritchevsky,Stephen B,Kubo,Michiaki,Kuusisto,Johanna,Lakka,Timo A,Langefeld,Carl D,Langenberg,Claudia,Launer,Lenore J,Lehne,Benjamin,Lewis,Cora E,Li,Yize,Liang,Jingjing,Lin,Shiow,Liu,Ching-Ti,Liu,Jianjun,Liu,Kiang,Loh,Marie,Lohman,Kurt K,Louie,Tin,Luzzi,Anna,Mägi,Reedik,Mahajan,Anubha,Manichaikul,Ani W,McKenzie,Colin A,Meitinger,Thomas,Metspalu,Andres,Milaneschi,Yuri,Milani,Lili,Mohlke,Karen L,Momozawa,Yukihide,Morris,Andrew P,Murray,Alison D,Nalls,Mike A,Nauck,Matthias,Nelson,Christopher P,North,Kari E,O'Connell,Jeffrey R,Palmer,Nicholette D,Papanicolau,George J,Pedersen,Nancy L,Peters,Annette,Peyser,Patricia A,Polasek,Ozren,Poulter,Neil,Raitakari,Olli T,Reiner,Alex P,Renström,Frida,Rice,Treva K,Rich,Stephen S,Robinson,Jennifer G,Rose,Lynda M,Rosendaal,Frits R,Rudan,Igor,Schmidt,Carsten O,Schreiner,Pamela J,Scott,William R,Sever,Peter,Shi,Yuan,Sidney,Stephen,Sims,Mario,Smith,Jennifer A,Snieder,Harold,Starr,John M,Strauch,Konstantin,Stringham,Heather M,Tan,Nicholas Y Q,Tang,Hua,Taylor,Kent D,Teo,Yik Ying,Tham,Yih Chung,Tiemeier,Henning,Turner,Stephen T,Uitterlinden,André G,van Heemst,Diana,Waldenberger,Melanie,Wang,Heming,Wang,Lan,Wang,Lihua,Wei,Wen Bin,Williams,Christine A,Wilson,Gregory Sr,Wojczynski,Mary K,Yao,Jie,Young,Kristin,Yu,Caizheng,Yuan,Jian-Min,Zhou,Jie,Zonderman,Alan B,Becker,Diane M,Boehnke,Michael,Bowden,Donald W,Chambers,John C,Cooper,Richard S,de Faire,Ulf,Deary,Ian J,Elliott,Paul,Esko,Tõnu,Farrall,Martin,Franks,Paul W,Freedman,Barry I,Froguel,Philippe,Gasparini,Paolo,Gieger,Christian,Horta,Bernardo L,Juang,Jyh-Ming Jimmy,Kamatani,Yoichiro,Kammerer,Candace M,Kato,Norihiro,Kooner,Jaspal S,Laakso,Markku,Laurie,Cathy C,Lee,I-Te,Lehtimäki,Terho,Magnusson,Patrik K E,Oldehinkel,Albertine J,Penninx,Brenda W J H,Pereira,Alexandre C,Rauramaa,Rainer,Redline,Susan,Samani,Nilesh J,Scott,James,Shu,Xiao-Ou,van der Harst,Pim,Wagenknecht,Lynne E,Wang,Jun-Sing,Wang,Ya Xing,Wareham,Nicholas J,Watkins,Hugh,Weir,David R,Wickremasinghe,Ananda R,Wu,Tangchun,Zeggini,Eleftheria,Zheng,Wei,Bouchard,Claude,Evans,Michele K,Gudnason,Vilmundur,Kardia,Sharon L R,Liu,Yongmei,Psaty,Bruce M,Ridker,Paul M,van Dam,Rob M,Mook-Kanamori,Dennis O,Fornage,Myriam,Province,Michael A,Kelly,Tanika N,Fox,Ervin R,Hayward,Caroline,van Duijn,Cornelia M,Tai,E Shyong,Wong,Tien Yin,Loos,Ruth J F,Franceschini,Nora,Rotter,Jerome I,Zhu,Xiaofeng,Bierut,Laura J,Gauderman,W James,Rice,Kenneth,Munroe,Patricia B,Morrison,Alanna C,Rao,Dabeeru C,Rotimi,Charles N,Cupples,L Adrienne
期刊：Nature Genetics影响因子：29.000
时间：2019起止号：2019 Apr;51(4):636-648
doi：10.1038/s41588-019-0378-y

Abstract

The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene-smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 new loci associated with lipids, some of which were detected only because association differed by smoking status. Additionally, we demonstrate the importance of including diverse populations, particularly in studies of interactions with lifestyle factors, where genomic and lifestyle differences by ancestry may contribute to novel findings.

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