CD4 response, lipid changes and liver outcome in 506 patients receiving nevirapine-based regimens for a median of 9 years

对接受奈韦拉平方案治疗的 506 例患者（中位随访时间为 9 年）的 CD4 反应、血脂变化和肝脏结局进行分析

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作者：Operario,Don,Underhill,Kristen,Chuong,Carolyn,Cluver,Lucie,Lagler,H,Grabmeier-Pfistershammer,K,Touzeau-Römer,V,Tobudic,S,Rieger,A,Burgmann,H,Pronin,AJ,Kaminskiy,GD,Huber,M,Ledergerber,B,Jaccard,R,Elzi,L,Furrer,H,Hirschel,B,Cavassini,M,Bernasconi,E,Schmid,P,Weber,R,Galli,L,Salpietro,S,Pellicciotta,G,Galliani,A,Piatti,PM,Hasson,H,Guffanti,M,Gianotti,N,Bigoloni,A,Lazzarin,A,Castagna,A,Fernandez-Ortega,C,Casillas,D,Dubed,M,Navea,L,Ramirez,A,Lopez,L,Paneque,T,Reinoso,Y,Vourvahis,M,Wong,R,Ndongo,NM,O'Gorman,M,Tawadrous,M,Cuffe,R,Ait-Khaled,M,Hughes,S,Min,S,Nichols,G,Thomas,D,Underwood,M,Yeo,JM,Faller,EM,Sugden,SM,MacPherson,PA,Madeddu,G,Fois,AG,Calia,GM,Becciu,F,Piras,B,Fiori,ML,Spada,V,Lovigu,C,Mannazzu,M,Pirina,P,Mura,MS,Broder,MS,Juday,T,Uy,J,Chang,EY,Bentley,TGK,Spagnuolo,V,Galli,L,Salpietro,S,Vinci,C,Cossarini,F,Travi,G,Rubinacci,A,Mignogna,G,Cernuschi,M,Bossolasco,S,Lazzarin,A,Castagna,A,Spinosa-Guzman,S,Van de Casteele,T,De La Rosa,G,De Doncker,P,Sension,M,Arns Da Cunha,C,Domingo,P,Supparatpinyo,K,Van De Casteele,T,De Doncker,P,Tomaka,F,van Lunzen,J,Gorriahn,D,Wünsche,T,Dupke,S,Gute,P,Schewe,CK,Ranneberg,B,Sterrantino,G,Borchi,B,Trotta,M,Bartolozzi,D,Leoncini,F,Grabmeier-Pfistershammer,K,Rieger,A,Schroeck,T,Schlag,M,Arribas,JR,Hill,A,Garcia,I,Anceau,A,Mocroft,A,Aragão,F,Vaz Pinto,I,Vera,J,Aichelburg,MC,Schlag,M,Rieger,A,Cridford,R,Thornton,A,Rayment,M,Mguni,S,Millett,D,Mandalia,S,Nardone,A,Tenant-Flowers,M,Sullivan,A,Ghosh,R,Anderson,J,Dashe,DR,Aydin Altuntas,O,Kumbasar Karaosmanoglu,H,Korkusuz,R,Nazlican,O,Mulinde,HF,Tweya,H,Chiwoko,J,Feldacker,C,Phiri,S,Nyirenda,M,Weigel,R,Mlundira,L,Cingolani,A,Torti,L,Pinnetti,C,de Gaetano Donati1,K,Murri,R,Tacconelli,E,Larocca,LM,Teofili,L,Page,ID,Phillips,M,Flegg,P,Palmer,R,Onigbogi,MO,Ojo,OY,Jarzebowski,W,Piketty,C,de Truchis,P,Caumes,E,Farhi,D,Lascaux,AS,Bouldouyre,MA,Derradji,O,Pacanowski,J,Dupin,N,Costagliola,D,Grabar,S,Mendez,J,Sarmento e Castro,R,Domingues da Silva,AR,Casado,JL,Domingo,P,Rubio,R,Antela,A,Lopez-Ruz,MA,Castro,A,Portilla,J,Ribera,E,Podzamczer,D,Oteo,JA,Galindo,J,Otero,S,Lozano,F,Estrada,V,Moltó,J,Moreno,S,Bonora,S,Calcagno,A,Viganò,O,Bigliano,P,Rusconi,S,Trentini,L,Tettoni,MC,Orofino,G,Salassa,B,Bramato,C,D'Avolio,A,Siccardi,M,Colella,E,Galli,M,Di Perri,G,Caso,A,Valencia,E,Moreno,V,Cervero,M,Sanz,J,Torres Perea,R,Nozza,S,Galli,L,Di Pietro,M,Mazzotta,F,Canducci,F,Pogliaghi,M,Chiappetta,S,Galli,A,Rusconi,V,Salpietro,S,Tambussi,G,Lazzarin,A,Arastéh,K,Ward,A,Plettenberg,A,Livrozet,JM,Cordes,C,Winston,A,Wang,E,Quinson,A,Cooper,V,Horne,R,Ewan,J,Ghosn,J,Chermak,A,Houssaini,A,Peytavin,G,Lambert-Niclot,S,Eychenne,N,Slama,L,Brunet,A,Duvivier,C,Simon,A,Marcelin,AG,Flandre,P,Katlama,C,Cuzin,L,Allavena,C,Levy-Bachelot,L,Valantin,MA,Mellliez,H,Pugliese,P,Poizot-Martin,I,Duvivier,C,Finkielsztejn,L,Abel,S,Martínez,E,Arranz,JA,Podzamczer,D,Lonca,M,Sanz,J,Barragán,P,Knobel,H,Ribera,E,Gutierrez,F,Valero,S,Clotet,B,Dalmau,D,Segura,F,Arribas,JR,Barrufet,P,Santos,I,Payeras,A,de Lazzari,E,Pich,J,Gatell,J,Portsmouth,S,Burnside,R,Lazzarin,A,Johnson,M,Valdez,H,Pérez,L,Aleman,J,Correa,C,Pérez,J,Fonseca,C,Aragones,C,Pérez,D,Alvarez,A,Vandamme,AM,Kourí,V,Van Laethem,K,Portsmouth,S,Valluri,S,Daeumer,M,Thiele,B,Valdez,H,Lewis,M,Craig,C,Thielen,A,James,I,Demarest,J,Heera,J,Ranger-Rogez,S,Al Jawhari,M,Nguyen,B,Pham Hong,N,Tran Quoc,T,Pascual,J,Doll,J,Harzic,M,Viretto,G,Weinbreck,P,Caldas,C,Andrade,P,Azevedo,C,Piñeiro,C,Serrão,R,Soares,J,Marques,R,Sarmento,A,Obermeier,MJ,Carganico,A,Dupke,S,Schranz,D,Cordes,C,Freiwald,M,Klausen,G,Köppe,S,Schuler,C,Mayr,C,Schleehauf,D,Berg,T,Krznaric,I,Baumgarten,A,Manolescu,LSC,Sultana,CM,Vagu,C,Temereanca,A,Ruta,SM,Skoura,L,Metallidis,S,Buckton,AJ,Mbisa,JL,Pilalas,D,Papadimitriou,E,Papoutsi,A,Haidich,AB,Valagouti,D,Tsachouridou,O,Antoniadou,ZA,Kollaras,P,Nikolaidis,P,Malisiovas,N,Pulido,F,Arribas,JR,Hill,A,van Delft,Y,Moecklinghoff,C,Rockstroh,J,Eron,J,Cooper,D,Steigbigel,R,Nguyen,BY,Xu,X,Wan,H,Rodgers,A,Miller,M,Leavitt,R,Sklar,P,Teppler,H,Marcelin,AG,Charpentier,C,Wirden,M,Descamps,D,Calvez,V,De La Rosa,G,Pattery,T,Picchio,G,Lathouwers,E,Villacian,J,Van der Borght,K,Zaccarelli,M,Lorenzini,P,Marconi,P,Forbici,F,Gori,C,Sette,P,Ceccherini-Silberstein,F,Narciso,P,Perno,CF,Antinori,A,Silva,C,Bento,D,Rijo,J,Alfaiate,D,Aldir,I,Araújo,C,Farinha,H,Mansinho,K,Gaytán-Martínez,JE,Mata-Marín,JA,Gutierrez-Escolano,F,Pérez-Saleme,L,Treviño-Pérez,S,Vázquez-Rosales,JG,Matías-Juan,N,Díaz-Ramos,RD,Arias-Flores,R,Zolopa,A,Towner,W,Lazzarin,A,Fätkenheuer,G,Butcher,D,Uy,J,Marcelin,AG,Charpentier,C,Ferreira,C,Wirden,M,Lemarchand,C,Descamps,D,Calvez,V,Pena,N Mantovani,Azevedo,R Gonçalves,Castro,D Funayama,Diaz,R Sobhie,Komninakis,S Vasconcelos,May,MT,Gompels,M,Sabin,CA,Jackson,AGA,Hill,A,Else,LJ,Back,DJ,Morley,R,Puls,R,Amin,J,Lin,E,Boffito,M,Piñeiro,C,Santos,AS,Cardoso,S,Nuak,J,Lucas,R,Ferreira,A,Xerinda,S,Tavares,M,Marques,R,Sarmento,A,Wedemeyer,H,Lovern,M,Underwood,M,Nichols,G,Song,I,Payne,BAI,Hateley,CA,Samuels,DC,Wilson,IJ,Santibanez-Koref,M,Price,DA,Chinnery,PF,Perry,MEO,Almaani,N,Desai,N,Fox,J,Larbalestier,N,Chilton,D,Rachlis,A,Gill,J,Harris,M,Macleod,J,Worthington,C,Brunetta,J,Tsang,A,Hew,H,Leith,J,Camacho,F,Turner,D,Fraser,C,Coroiu,C,Tollinchi,F,Hittinger,G,Mokhtari,S,Granet,P,Faucher-Zaegel,O,Madrid,A,Menard,A,Mattei,JL,Chadapaud,S,Premchand,N,Golds,K,Tan,PY,Bittiner,I,Sanker,N,Ong,ELC,Stellbrink,HJ,Rugina,S,Zagler,C,Esser,S,Castagna,A,Gazzard,B,Hill,A,van Delft,Y,Marks,S,Krznaric,I,Wienbreyer,A,Zoufaly,A,Kreckel,P,Esser,S,Harrer,T,Jansen,K,Michalik,C,Hertling,S,Sloan,RD,Kuhl,BD,Kramer,VG,Donahue,DA,Bar-Magen,T,Tressler,R,Wainberg,MA,Hristea,A,Petre,R,Gliga,S,Olaru,I,Ion,M,Moroti,R,Popescu,C,Mihailescu,R,Radulescu,M,Arama,V,Mori,J,Westby,M,Tawadrous,M,van der Ryst,E,Charles,C,Mata-Marín,JA,Gaytán-Martínez,JE,Arroyo-Anduiza,CI,Calderón-Rodriguez,G,Pironti,A,Sönnerborg,A,Zazzi,M,Kaiser,R,Struck,D,Clotet,B,Vandamme,ÀM,Incardona,F,Lengauer,T,Rosen-Zvi,M,Prosperi,M,Martín-Carbonero,L,Rallón,NI,Benito,JM,Poveda,E,González-Lahoz,J,Soriano,V,Eron,J,Livrozet,JM,Morlat,P,Lazzarin,A,Katlama,C,Hawkins,T,Fujiwara,T,Cuffe,R,Vavro,C,Santiago,J,Ait-Khaled,M,Min,S,Yeo,JM,Ferrara,S,Tartaglia,A,Santantonio,T,Grisorio,B,Bock,P,Fatti,G,Grimwood,A,Perez-Molina,JA,Mora-Rillo,M,Suarez-Lozano,I,Casado,JL,Teira,R,Rivas,P,Pedrol,E,Hernando,A,Domingo,P,Barquilla,E,Esteban,H,Gonzalez-Garcia,J,Steingrover,R,Nievaard,MAF,Lange,JMA,Nieuwkerk,PT,Prins,JM,Tsarenko,SP,Kravchenko,AV,Kanestri,VG,Maximov,SL,Cervero,M,Alcázar,V,García-La Calle,C,Sanz,R,Agud,JL,Bhatti,L,Shah,S,Khanlou,H,Baudry,T,Boibieux,A,Gagnieu,MC,Cotte,L,Livrozet,JM,Miahles,P,Makhloufi,D,Chidiac,C,Peyramond,D,Ferry,T,Jevtovic,DJ,Salemovic,DR,Ranin,JT,Garvey,LJ,Higgs,C,Mohammed,P,Nelson,M,Winston,A,Tyrer,M,Swaden,L,Marshall,NJ,Johnson,M,Marques,N,Seixas,D,Crespo,P,Malcata,L,Vaz,J,Mota,V,Morais,C,Oliveira,J,Duque,V,Saraiva da Cunha,J,Meliço-Silvestre,A,Domingo,P,Arazo,P,Casado,JL,Castaño,MA,Ferrer,E,Goenaga,MA,Granados,R,Pulido,F,Rodriguez,J,Rubio,R,Sanz,J,Viciana,P,Qaqish,R,van Wyk,J,King,MS,Avihingsanon,A,Apornpong,T,Kerr,SJ,Ananworanich,J,Ruxrungtham,K,Lazzarin,A,Johnson,M,Ribera,E,Weitner,L,Chen,SS,Warren,DR,Allan,S,Daly,RA,Yoganathan,Y,Barrett,S,Joseph,A,Tariq,A,Saing,CW,Williams,C,Lane,C,Sikorska,J,Bleijenberg,MP,Bierman,WFW,Jaglall,C,Heymans,MW,ten Doesschate,MC,Nieuwkerk,PT,Smits,PH,van Eer,M,Vreden,S,Francisci,D,Falcinelli,E,Belfiori,B,Petito,E,Mezzasoma,M,Baldelli,F,Gresele,P,Kaminskiy,GD,Pronin,AJ,Schulman,S,Rotshild,V,Pops,K Olshtein,Korem,M,Israel,S,Hauzi,M,Maayan,S,Palacios,R,González-Correa,JA,Ruiz,J,Nuño,E,Márquez,M,de la Cruz,JP,Santos,J,Schneider,L,Houssaini,A,Lambert,S,Peytavin,G,Agher,R,Chermak,A,Flandre,P,Calvez,V,Marcelin,AG,Ghosn,J,Katlama,C,Maroldo,L,Fredrick,LM,Robinson-Morgan,K,Trinh,R,Podsadecki,TJ,Orkin,C,DeJesus,E,Khanlou,H,Stoehr,A,Supparatpinyo,K,Van de Casteele,T,Lathouwers,E,Spinosa-Guzman,S,Tossonian,HK,Raffa,JD,Alenezi,O,Anderson,K,Jassemi,S,Wight,K,DeVlaming,S,Conway,B,Llibre,JM,Martínez,E,Barreiro,P,Escrig,R,Ribera,E,Cervantes,M,Imaz,A,Gutierrez,F,Knobel,H,Ornelas,A,Zamora,FX,Clotet,B,Bruyand,M,Geffard,S,Lawson-Ayayi,S,Dauchy,F,Miremont-Salamé,G,Greib,C,Farbos,S,Morlat,P,Dabis,F,Cenderello,G,Piscopo,R,Feasi,M,Penco,G,Bobbio,N,Cassola,G,Jansen,K,Sönnerborg,A,Pugliese,P,Biguenet,S,Eychenne,JL,Brockmeyer,NH,Michalik,C,Dupke,S,Jaeger,H,Plettenberg,A,Butcher,D,Jiménez-Expósito,MJ,KompNet,HIV,Doroana,M,Piñeiro,C,Maltez,F,Fonseca,P,Oliveira,J,Mansinho,K,Horta,A,Teófilo,E,Aguas,M,Germano,I,Faria,D,Grant,A,Kamuntu,Y,Read,P,Kulasegaram,R,Paniagua,S Plata,Lopez,N Trovato,Romera,I Castillo,Larisgoitia,A Ais,Cano,J Bellon,Saez,M Sanjurjo,Landonio,S,Meraviglia,P,Capetti,AF,Di Biagio,A,Lo Caputo,S,Sterrantino,G,Ammassari,A,Menzaghi,B,Franzetti,M,De Socio,G,Pellicanò,G,Mazzotta,E,Zucchi,P,Rizzardini,G,Ghosn,J,Delaugerre,C,Pinta,A,Pierre,N,Etienne,D,Raffi,F,Morand-Joubert,L,DeJesus,E,Mills,A,Bhatti,L,Conner,C,Storfer,S,Le Moal,G,Beraud,G,Prazuck,T,Hocqueloux,L,Dupuis,A,Venisse,N,Nhung,VTT,Colby,D,Khanh,TH,Viet,TT,Lu,D,Thuy,HT,An,B,Giang,LT,Temereanca,A,Sultana,CM,Manolescu,L,Vagu,C,Grancea,C,Ruta,S,Pattery,T,Van Cauwenberge,A,Van Hove,M,Smits,V,Van Soom,K,Villacian,J,Ganesan,A,Thatchinamoorthy,G,Saramini,S,Martin,N,Perez-Valero,I,San Jose Valiente,B,Mora,M,Bernardino-Serna,JI,Gonzalez,J,Gaya,F,Zamora,FX,Pena,JM,Arribas,JR,Fox,D,O’Connor,R,Mallon,P,McMahon,G,Mocroft,A,Lifson,AR,Touloumi,G,Neuhaus,J,Fox,Z,Palfreeman,A,Vjecha,M,Hodder,S,De Wit,S,Lundgren,JD,Phillips,AN,Zucman,D,Rouzioux,C,Avettand-Fenoel,V,Panagopoulos,P,Paraskevis,D,Sypsa,V,Detsika,M,Protopapas,K,Sakka,V,Poulakou,G,Papadopoulos,A,Petrikkos,G,Hatzakis,A,Afonso,C,Zagalo,A,Janeiro,N,Antunes,F,Parczewski,M,Leszczyszyn-Pynka,M,Bander,D,Urbañska,A,Kaczmarczyk,M,Ciechanowicz,S,Boron-Kaczmarska,A,Wikman,P,Safont,P,Perez-Elías,MJ,Moreno,A,Dronda,F,Moreno,S,Casado,JL,Badura,R,Antunes,RJG,Janeiro,N,Afonso,C,Antunes,F,Taylor,GP,Douglas,M,Smith,J,Brolund,AB,Ilchmann,C,Ganschow,R,Degen,O,Plettenberg,A,Brockmeyer,NH,Haastert,B,Dupke,S,Schewe,CK,Rausch,M,Hower,M,Arendt,G,Jansen,K,KompNet,HIV,Surah,S,Oshea,S,Costelloe,S,Hanlon,M,Mullen,J,Chrystie,I,Taylor,GP,De Ruiter,A,Van der Linden,D,Purchase,S,McKerrow,NH,Yurchenko,YO,Stepchenkova,T,Karnets,KI,Martinenko,MO,Nabwera,HM,Mwaringa,S,Kimutai,R,Berkley,JA,Chiwoko,J,Mhango,E,Phiri,S,Weigel,R,Dickinson,L,Chaponda,M,Carr,D,van Oosterhout,JJ,Kumwenda,J,Lalloo,DG,Pirmohamed,M,Heyderman,R,Khoo,SH,Sterne,J,Monera,TG,Maponga,CC,Ashby,J,Garvey,LJ,Erlwein,OW,Lamba,H,Weston,R,Legg,K,McClure,MO,Dickinson,L,D'Avolio,A,Back,DJ,Winston,A,Moltó,J,Valle,M,Miranda,C,Cedeño,S,Negredo,E,Barbanoj,MJ,Clotet,B,Portegies,P,Fellay,J,Dickinson,L,Jackson,AGA,Garvey,LJ,Watson,V,Khoo,SH,Winston,A,Boffito,M,Davies,GR,Back,DJ,Sax,PE,Meyers,JL,Mugavero,MJ,Davis,KL,Zhang,Y,Owen,A,Egan,D,Sarfo,SF,Baumgarten,A,Lutz,T,Kreckel,P,Wellmann,E,Alshuth,U,Mauss,S,Rockstroh,J,Crauwels,HM,van Schaick,E,van Heeswijk,RPG,Vanveggel,S,Boven,K,Vis,P,Vogel,M,Sekar,V,De La Rosa,G,Van de Casteele,T,Spinosa-Guzman,S,Vis,P,Hoetelmans,RMW,Walker,AS,Mugyenyi,P,Munderi,P,Hakim,J,Kekitiinwa,AA,Katabira,E,Gilks,CF,Kityo,C,Nahirya-Ntege,P,Nathoo,K,Gibb,D,Ho,A,McGarry,G,Peters,E,Foster,C,Martinelli,L,Francisci,D,Sgrelli,A,Baldelli,F,Reekie,J,Gatell,J,Yust,I,Bakowska,E,Rachmanova,A,Losso,M,Krasnov,M,Francioli,P,Kowalska,J,Mocroft,A,Dumitru,IM,Rugina,S,Dumitru,E,Cernat,RC,Diaconu,S,Mitroi,C Maxim,Schambelan,M,Ramaiah,K Ayodhya,Sudha Rani,B,Anand,R,Ramola,S,Satish Babu,P,Ramesh Babu,R,Lambert,JS,Else,LJ,Jackson,V,Dickinson,L,Back,DJ,Brennan,M,Weldridge,C,Coulter-Smith,S,Gibbons,S,Khoo,SH,Rusconi,S,Vitiello,P,Adorni,F,Colella,E,Focà,E,Capetti,AF,Meraviglia,P,Abeli,C,Bonora,S,D'Annunzio,M,Di Biagio,A,Di Pietro,A,Butini,L,Orofino,G,Farina,S,d'Ettorre,G,Francisci,D,Soria,A,Buonomini,AR,Tommasi,C,Trotta,MP,Capasso,M,Merlini,E,Marchetti,GC,Viard,JP,Souberbielle,JC,Kirk,O,Knysz,B,Losso,M,Gatell,J,Pedersen,C,Bogner,JR,Mocroft,A,Lundgren,JD,Kravchenko,AV,Kuznetsova,AV,Kozyrev,OA,Lukyanova,VA,Kanestri,VG,Edwards-Jackson,N,Kerr,SJ,Tieu,HV,Ananworanich,J,Hammer,SM,Ruxrungtham,K,Phanuphak,P,Avihingsanon,A,Skeie,L,Skrede,T,Maeland,A,Lodi,S,Kücherer,C,Kran,AM Bakken,Masquelier,B,Monforte,A d'Arminio,Gill,J,Dunn,D,Pillay,D,Porter,K,Chaychuk,TA,Gankina,NU,Nikonova,OG,Currier,J,Popova,AA,Kravchenko,AV,Kozhevnikova,GM,Serebrovskaya,LV,Fux,CA,Zimina,VN,Vasilieva,IA,Kravchenko,AV,Batyrov,FA,De Cock,KM,Lederman,M,Liuzzi,G,Vairo,F,Chaula,Z,Nguhuni,B,Nicastri,E,Bevilacqua,N,Cannas,A,Paglia,MG,Ippolito,G,Hakim,J,Minaeva,SV,Moshkovich,GF,Ssewankambo,F,Nalugwa,C,Sempa,J,Walusimbi,J,Kambugu,A,Spire,B,Ellis,S,Graham,L,Price,DA,Ong,ELC,Williams,B,Iwuji,CC,Pao,D,Gilleece,Y,Fisher,M,Churchill,D,Sönnerborg,A,Mocroft,A,Lundgren,JD,Raben,D,Gatell,J,Vassilenko,A,Hadziosmanovic,V,Bergovac,J,Sørensen,H,Cusini,M,Clumeck,N,Gazzard,B,Rockstroh,J,Zuin,M,D'Arminio Monforte,A,Merlini,E,Sinigaglia,E,Carpani,G,Bini,T,d'Arminio Monforte,A,Marchetti,GC,Amon,J,Brännström,J,Svedhem,V,Yilmaz,A,Blaxhult,A,Wendahl,S,Sönnerborg,A,Seclén,E,Gonzalez,M,Martín-Carbonero,L,Gellermann,H,Cairns,V,Distel,M,Kadus,W,Soriano,V,Poveda,E,Walusimbi,J,Birabwa,E,Nabankema,E,AnneMarie,A,Lutalo,I,Nakiwooga,A,Schapiro,J,Simoes,MM,Marques,CO,Albergaria,F,Guerreiro,C,Pereira,A,Correia,J,Castela,J,Montaner,J,Bennett,J,Valdez,H,Chapman,D,Biswai,P,Lewis,M,Craig,C,Heera,J,Ellery,S,Swenson,LC,Harrigan,PR,Lodwick,RK,Sabin,CA,Phillips,AN,Arribas,JR,Woolley,WFC,Babu,C,Sukthankar,A,McQuillan,O,Clumeck,N,Arribas,JR,Pulick,P,Fätkenheuer,G,Hill,A,Van Delft,Y,Moecklinghoff,C,Bloch,M,Hoy,J,Cunningham,N,Roth,N,Andrianopoulos,N,Rayner,C,Carr,A,Bierman,WFW,Humphreys,EH,van Agtmael,MA,Boucher,CA,Rutherford,GW,Hidalgo,JA,Castillo,N,Agurto,C,Zhang,C,Denti,P,Simonsson,USH,Maartens,G,Karlsson,MO,McIlleron,H,Siccardi,M,D'Avolio,A,Baietto,L,Simiele,M,Bonora,S,Back,DJ,Di 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期刊：Journal of the International Aids Society影响因子：4.900
时间：2010起止号：2010;13(Suppl 4):P81
doi：10.1186/1758-2652-14-25

Abstract

BACKGROUND: Previous research has suggested that orphaned children and adolescents might have elevated risk for HIV infection. We examined the state of evidence regarding the association between orphan status and HIV risk in studies of youth aged 24 years and younger. METHODS: Using systematic review methodology, we identified 10 studies reporting data from 12 countries comparing orphaned and non-orphaned youth on HIV-related risk indicators, including HIV serostatus, other sexually transmitted infections, pregnancy and sexual behaviours. We meta-analyzed data from six studies reporting prevalence data on the association between orphan status and HIV serostatus, and we qualitatively summarized data from all studies on behavioural risk factors for HIV among orphaned youth. RESULTS: Meta-analysis of HIV testing data from 19,140 participants indicated significantly greater HIV seroprevalence among orphaned (10.8%) compared with non-orphaned youth (5.9%) (odds ratio = 1.97; 95% confidence interval = 1.41-2.75). Trends across studies showed evidence for greater sexual risk behaviour in orphaned youth. CONCLUSIONS: Studies on HIV risk in orphaned populations, which mostly include samples from sub-Saharan Africa, show nearly two-fold greater odds of HIV infection among orphaned youth and higher levels of sexual risk behaviour than among their non-orphaned peers. Interventions to reduce risk for HIV transmission in orphaned youth are needed to address the sequelae of parental illness and death that might contribute to sexual risk and HIV infection.

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