【文献解析】免疫检查点抑制剂双药联合与免疫检查点抑制剂联合酪氨酸激酶抑制剂在IMDC中高危转移性肾细胞癌患者中的真实世界疗效比较
1. 领域背景与文献引入文献英文标题：Comparison of real-world effectiveness of immune checkpoint inhibitor doublet versus immune checkpoint inhibitor plus tyrosine kinase inhibitor combinations in IMDC intermediate- and poor-risk metastatic renal cell carcinoma；发表期刊：未公开；影响因子：未公开；研究
【文献解析】补体激活介导胆管癌抗PD-1治疗相关唾液腺炎免疫不良反应并预测疗效
1. 领域背景与文献文献英文标题：Complement activation drives sialadenitis immune-related adverse events and predicts anti-PD-1 efficacy in cholangiocarcinoma；发表期刊：Cancer Immunology, Immunotherapy；影响因子：7.0（2024年）；研究领域：肿瘤免疫治疗（胆管癌方向）。胆管癌是全球第二常见的原发性肝癌，恶
【文献解析】冷冻消融联合CpG与双重免疫检查点抑制剂在MASH相关肝细胞癌小鼠模型中诱导系统性抗肿瘤免疫
1. 领域背景与文献引入文献英文标题：Combination of cryoablation, CpG, and dual checkpoint inhibition induces systemic antitumor immunity in a murine model of MASH-associated hepatocellular carcinoma；发表期刊：Journal of Surgical Research；影响因子：3.3（2024年）；研究领域：肿瘤免疫治疗（肝细胞癌方向
【文献解析】Spatial multi-omics reveals region-specific tumor microenvironment remodeling and therapeutic resistance mechanisms in hepatocellular carcinoma treated with lenvatinib, anti-PD-1, and radiotherapy
1. 领域背景与文献文献英文标题：Spatial multi-omics reveals region-specific tumor microenvironment remodeling and therapeutic resistance mechanisms in hepatocellular carcinoma treated with lenvatinib, anti-PD-1, and radiotherapy；发表期刊：Journal of Experimental & Clinical Cancer Research；影响因
【文献解析】头颈部鳞状细胞癌中肿瘤相关巨噬细胞的动态变化：与临床特征的关联及PD-1阻断的影响
1. 领域背景与文献文献英文标题：Tumor-associated macrophages dynamics in head and neck squamous cell carcinoma: association with clinical features and impact of PD-1 blockade；发表期刊：Cancer Immunology, Immunotherapy；影响因子：6.7（2024年）；研究领域：肿瘤免疫治疗（头颈部鳞状细胞癌）头颈部鳞状细胞
【文献解析】A2B受体拮抗剂联合PD-1抑制剂通过降低非小细胞肺癌中TGFβ信号通路增强抗肿瘤疗效
1. 领域背景与文献文献英文标题：Combination of A2B receptor antagonist and PD-1 inhibitor enhances antitumor efficacy by reducing TGFβ signaling in non-small cell lung cancer；发表期刊：Cancer Immunology, Immunotherapy；影响因子：未公开；研究领域：非小细胞肺癌免疫治疗非小细胞肺癌（NSCLC）是全球发病率
【文献解析】免疫检查点抑制剂相关肺炎在不同恶性肿瘤患者中的临床特征、预后因素及治疗策略分析
1. 领域背景与文献文献英文标题：Clinical characteristics, prognostic factors, and management strategies of immune checkpoint inhibitor-related pneumonitis across diverse malignancies；发表期刊：Cancer Immunology, Immunotherapy；影响因子：未公开；研究领域：肿瘤免疫治疗不良反应（免疫检查点抑制剂相关肺炎
【文献解析】YAP1-CD70信号轴介导前列腺癌免疫逃逸及增强免疫检查点阻断响应的机制研究
1. 领域背景与文献文献英文标题：未完整公开，核心研究主题为YAP1-CD70信号轴调控前列腺癌免疫逃逸及免疫检查点阻断响应；发表期刊：未明确标注（DOI：10.1186/s40364-025-00880-1）；影响因子：未公开；研究领域：肿瘤免疫治疗（前列腺癌方向）。领域共识：免疫检查点阻断（ICB）疗法自2011年首次获批用于恶性黑色素瘤治疗
【文献解析】核心蛋白聚糖促进T细胞介导的抗肿瘤免疫并增强抗PD1免疫治疗疗效
1. 领域背景与文献引入文献英文标题：Decorin facilitates T cell-mediated antitumor immunity and augments the efficacy of anti-PD1 immunotherapy；发表期刊：Cancer Immunology, Immunotherapy；影响因子：未公开；研究领域：肿瘤免疫治疗。领域共识：免疫检查点阻断（ICB）疗法尤其是抗PD1/PD-L1单抗的应用是肿瘤治疗
【文献解析】尼达尼布通过抑制髓系来源抑制细胞和癌相关成纤维细胞增强PD-1阻断的抗肿瘤疗效
1. 领域背景与文献文献英文标题：Nintedanib enhances the antitumor efficacy of pd-1 blockade, potentially through inhibition of myeloid-derived suppressor cells and cancer-associated fibroblasts；发表期刊：Cancer Immunology, Immunotherapy；影响因子：未公开；研究领域：肿瘤免疫治疗。领域共识：程序性死亡