搜索结果 共 135 条

【文献解析】PD-1/PD-L1阻断耐药中的免疫压力重分布:机制、生物标志物与治疗设计

1. 领域背景与文献文献英文标题:Immune-pressure redistribution in resistance to PD-1/PD-L1 blockade: mechanisms, biomarkers, and therapeutic design;发表期刊:未明确提供;影响因子:未公开;研究领域:肿瘤免疫治疗,程序性死亡受体1(PD-1)/程序性死亡配体1(PD-L1)阻断耐药机制研究。领域共识:PD-1/PD-L1阻

【文献解析】通过IL-6/JAK1/STAT3信号轴靶向Tc17细胞分化减轻免疫检查点抑制剂相关结肠炎并促进肿瘤免疫

1. 领域背景与文献文献英文标题:Targeting Tc17 cell differentiation via the IL-6/JAK1/STAT3 signaling axis to attenuate immune checkpoint inhibitor-related colitis and promote tumor immunity;发表期刊:Cell Commun Signal;影响因子:未公开;研究领域:肿瘤免疫治疗相关不良反应,细分方向为免疫检查点抑制剂

【文献解析】乙酰化稳定的METTL3通过促进SPP1翻译诱导CD8+T细胞耗竭驱动肺癌抗PD-1耐药

1. 领域背景与文献文献英文标题:Acetylation-stabilized METTL3 drives anti-PD-1 resistance in lung cancer by promoting CD8+ T cell exhaustion via SPP1 translation;发表期刊:Cell Commun Signal;影响因子:未公开;研究领域:肿瘤学(肺癌免疫治疗耐药)。领域共识:免疫检查点抑制剂抗PD-1治疗是当前晚期肺癌的

【文献解析】C5aR1阳性PMN-MDSC诱导的血管生成限制放疗联合抗PD-1免疫治疗的疗效

1. 领域背景与文献文献英文标题:C5aR1-positive PMN-MDSC-induced angiogenesis limits the efficacy of radiotherapy combined with Anti-PD-1 immunotherapy;发表期刊:Cell Commun Signal;影响因子:未公开;研究领域:结直肠癌联合治疗耐药机制,细分领域为肿瘤免疫微环境调控。领域共识:结直肠癌是全球发病率排名前

【文献解析】免疫检查点阻断可通过不依赖1型常规树突状细胞的方式促进原发肿瘤排斥且不获得免疫记忆

1. 领域背景与文献文献英文标题:Immune checkpoint blockade facilitates primary tumor rejection in a cDC1-independent manner without immunological memory acquisition;发表期刊:Cancer Immunol Immunother;影响因子:未公开;研究领域:肿瘤免疫治疗(免疫检查点阻断机制方向)。领域共识:免疫检查点阻断是目前

【文献解析】抗PD-1联合IFN-α1b加或不加安罗替尼一线治疗不可切除晚期黑色素瘤的疗效与安全性:一项真实世界队列研究

1. 领域背景与文献文献英文标题:Efficacy and safety of anti-PD-1 combined with IFN-α1b with or without anlotinib as the first-line therapy in patients with unresectable advanced melanoma: a real-world cohort study;发表期刊:Cancer Immunol Immunother;影响因子:未公开;研究领域:肿瘤学临床,晚期黑色

【文献解析】PD-L1 vNAR通过激活瘦素-STAT3信号通路调控毛干伸长促进毛发生长

1. 领域背景与文献文献英文标题:PD-L1 vNAR promotes hair growth by modulating hair shaft elongation through activating the leptin-STAT3 signaling发表期刊:Cell Communication and Signaling;影响因子:未公开;研究领域:毛发再生与分子信号调控毛发疾病尤其是雄激素性脱发是全球范围内高发的皮肤疾病,现有临床

【文献解析】PD-L1阳性外泌体作为多发性骨髓瘤的生物标志物与治疗靶点:对CAR-T疗效及联合免疫治疗的意义

1. 领域背景与文献文献英文标题:PD-L1+ exosomes as biomarkers and therapeutic targets in multiple myeloma: implications for CAR-T efficacy and combination immunotherapy;发表期刊:Biomark Res;影响因子:未公开;研究领域:血液肿瘤学(多发性骨髓瘤精准治疗方向)领域共识:多发性骨髓瘤(MM)是一种起源于浆

【文献解析】空间分割放疗联合PD-L1阻断在腹膜转移临床前模型中实现优异的抗肿瘤疗效与安全性

1. 领域背景与文献文献英文标题:Spatially fractionated radiotherapy with PD-L1 blockade achieves superior antitumor efficacy and safety in a preclinical model of peritoneal metastasis;发表期刊:Cancer Immunol Immunother;影响因子:未公开;研究领域:放射肿瘤学、肿瘤免疫治疗,聚焦胃肠道肿瘤腹膜转移的免

【文献解析】颈部淋巴结清扫数目对复发头颈部鳞状细胞癌免疫检查点抑制剂疗效的影响

1. 领域背景与文献文献英文标题:Impact of neck nodal yield on immune checkpoint inhibitor outcome after recurrence in head and neck squamous cell carcinoma;发表期刊:Cancer Immunol Immunother;影响因子:未公开;研究领域:头颈部鳞状细胞癌免疫治疗、肿瘤预后生物标志物头颈部鳞状细胞癌(HNSCC)是全球范围