Proceedings of the 23(rd) Paediatric Rheumatology European Society Congress: part three: Genoa, Italy. 28 September – 01 October 2016

第23届欧洲儿科风湿病学会大会论文集：第三部分：意大利热那亚，2016年9月28日至10月1日

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作者：de Jong,J W,Postma,D S,van der Mark,T W,Koëter,G H,Papa,Riccardo,Consolaro,Alessandro,Minoia,Francesca,Caorsi,Roberta,Magnano,Gianmichele,Gattorno,Marco,Ravelli,Angelo,Picco,Paolo,Pillon,Roberto,Marafon,Denise Pires,Meli,Lidia,Bracaglia,Claudia,Taddio,Andrea,De Benedetti,Fabrizio,Turan,Enes,Kilic,Sara Sebnem,Itoh,Yasuhiko,Shigemori,Tomoko,Yamanishi,Shingo,Nagasaki,Hidehiko,Tarakci,Ela,Arman,Nilay,Tarakci,Devrim,Akgul,Yusuf S,Kasapcopur,Ozgur,Wilson,Emily,Lythgoe,Hanna,Smith,Eve,Preston,Jenny,Beresford,Michael W,Spiegel,Lynn R,Stinson,Jennifer,Connelly,Mark,Huber,Adam,Luca,Nadia,Tsimicalis,Argerie,Luca,Stephanie,Tajuddin,Naweed,Berard,Roberta,Barsalou,Julie,Campillo,Sarah,Feldman,Brian,Tse,Shirley,Dancey,Paul,Duffy,Ciaran,Johnson,Nicole,McGrath,Patrick,Shiff,Natalie,Tucker,Lori,Victor,Charles,Spiegel,Lynn R,Lalloo,Chitra,Harris,Lauren,Cafazzo,Joseph,Tucker,Lori,Houghton,Kristin,Feldman,Brian,Luca,Nadia,Laxer,Ronald,Stinson,Jennifer,Arman,Nilay,Tarakci,Ela,Kasapcopur,Ozgur,Rooney,Madeleine,Campbell,Roisin,Wright,Catherine,Armbrust,Wineke,Lelieveld,Otto,Tuinstra,Jolanda,Wulffraat,Nico,Bos,Joyce,Cappon,Jeanette,van Rossum,Marion,Hagedoorn,Mariët,Vermé,Anna,Lampela,Ylva,Ozdogan,Ayse Huri,Ugurlu,S,Barut,K,Androvic,A,Kasapçopu,O,Wilson,Emily,Etheridge,Jody,Smith,Eve,Dobson,Katie,Kemp,Sue,Beresford,Michael W,Horne,AnnaCarin,Palmblad,Karin,Höglund,Malin,Stepanenko,Natalia,Salugina,Svetlana,Fedorov,Evgeny,Nikishina,Irina,Kaleda,Maria,Arman,Nilay,Tarakci,Ela,Barut,Kenan,Adrovic,Amra,Sahin,Sezgin,Kasapcopur,Ozgur,Arman,Nilay,Tarakci,Ela,Kasapcopur,Ozgur,Toumoulin,Laurence,Frossard,Johnny,Archimbaut,Stephanie,Paitier,Anne,Guastalli,Rolande,Czitrom,Severine Guillaume,Charuvanij,Sirirat,Chaiyadech,Chollada,Miyamae,Takako,Yamanaka,Hisashi,Picard,Cecile,Thouvenin,Guillaume,Kannengiesser,Caroline,Dubus,Jean-Christophe,Jeremiah,Nadia,Rieux-Laucat,Frédéric,Crestani,Bruno,Secq,Véronique,Ménard,Christelle,Reynaud-Gaubert,Martine,Thivolet-Bejui,Françoise,Reix,Philippe,Belot,Alexandre,Batu,Ezgi Deniz,Sonmez,Hafize Emine,Erden,Abdulsamet,Taskiran,Ekim Z,Karadag,Omer,Kalyoncu,Umut,Oncel,İbrahim,Kaplan,Berkan,Arici,Zehra Serap,Temucin,Cagri Mesut,Topaloglu,Haluk,Bilginer,Yelda,Alikasifoglu,Mehmet,Ozen,Seza,Van Eyck,Lien,De Langhe,Ellen,Jéru,Isabelle,Van Nieuwenhove,Erika,Lagou,Vasiliki,Baker,Paul J,Garcia-Perez,Jocelyn,Dooley,James,De Somer,Lien,Sciot,Raf,Jeandel,Pierre-Yves,Ruuth-Praz,Julia,Copin,Bruno,Medley-Hashim,Myrna,Megarbane,Andre,Savic,Sinisa,Goris,An,Amselem,Serge,Liston,Adrian,Masters,Seth,Wouters,Carine,Okamoto,Nami,Sugita,Yuko,Shabana,Kousuke,Murata,Takuji,Tamai,Hiroshi,Ferenczová,Juliana,Banóova,Erika,Mrážik,Pavol,Vargova,Veronika,Bajramovic,Dubravko,Novacki,Ksenija Stekic,Potocki,Kristina,Frkovic,Marijan,Jelusic,Marija,Nikishina,Irina,Kostareva,Olga,Arsenyeva,Svetlana,Kaleda,Maria,Shapovalenko,Anna,Jans,Lennart,Herregods,Nele,Jaremko,Jacob,Joos,Rik,Dehoorne,Joke,Herregods,Nele,Jaremko,Jacob,Baraliakos,Xenofon,Dehoorne,Joke,Joos,Rik,Jans,Lennart,Ramiro,Sofia,Casasola-Vargas,Julio C,van der Heijde,Désirée,Landewé,Robert,Burgos-Vargas,Ruben,Burgos-Vargas,Ruben,Tse,Shirley M,Horneff,Gerd,Unnebrink,Kristina,Anderson,Jaclyn K,Kisaarslan,Aysenur Paç,Sözeri,Betül,Gündüz,Zübeyde,Zararsız,Gökmen,Poyrazoğlu,Hakan,Düşünsel,Ruhan,Ouchi,Kazutaka,Akioka,Shinji,Kubo,Hiroshi,Nakagawa,Norio,Hosoi,Hajime,Lamot,Lovro,Borovecki,Fran,Kapitanovic,Sanja,Gotovac,Kristina,Vidovic,Mandica,Lamot,Mirta,Bosak,Edi Paleka,Harjacek,Miroslav,Russo,Ricardo A,Katsicas,María M,Vargas,Ruben Burgos,Ortiz-Peyegahud,Ana L,Pingping,Zhang,Yikun,Mou,Jun,Qi,Yutong,Jiang,Jieruo,Gu,Kostik,Mikhail M,Ekaterina,Shilova,Avrusin,Ilia,Korin,Yuriy,Kopchak,Olga,Isupova,Eugenia,Chikova,Irina,Tatyana,Panova,Dubko,Margarita,Masalova,Vera,Snegireva,Ludmila,Kornishina,Tatyana,Kalashnikova,Olga,Chasnyk,Vyacheslav,Kostik,Mikhail M,Chikova,Irina,Isupova,Eugenia,Dubko,Margarita,Masalova,Vera,Snegireva,Ludmila,Kornishina,Tatyana,Likhacheva,Tatyana,Kalashnikova,Olga,Chasnyk,Vyacheslav,Ruperto,N,Brunner,H I,Quartier,P,Constantin,T,Alexeeva,E,Schneider,R,Kone-Paut,I,Schikler,K,Marzan,K,Wulffraat,N,Padeh,S,Chasnyk,V,Wouters,C,Kuemmerle-Deschner,J B,Kallinich,T,Lauwerys,B,Haddad,E,Nasonov,E,Trachana,M,Vougiouka,O,Leon,K,Speziale,A,Lheritier,K,Vritzali,E,Martini,A,Lovell,D,Ter Haar,Nienke,Scholman,Rianne,de Jager,Wilco,Tak,Tamar,Leliefeld,Pieter,Vastert,Bas,de Roock,Sytze,Ter Haar,Nienke,Scholman,Rianne,de Jager,Wilco,de Ganck,Ariane,Ryter,Nadia,Lavric,Miha,Foell,Dirk,de Roock,Sytze,Vastert,Bas,Modica,Renee F,Lomax,Kathleen G,Batzel,Pamela,Cassanas,Armelle,Elder,Melissa E,Denisova,Rina,Alexeeva,Ekaterina,Valieva,Saniya,Bzarova,Tatyana,Isayeva,Kseniya,Sleptsova,Tatyana,Lomakina,Olga,Chomahidze,Alexandra,Soloshenko,Margarita,Shingarova,Meyry,Kachshenko,Elena,De Jager,Wilco,Vastert,Sebastiaan J,Mijnheer,Gerdien,Prakken,Berent J,Wulffraat,Nico M,Sönmez,Hafize E,Karhan,Asuman N,Batu,Ezgi D,Bilginer,Yelda,Arıcı,Zehra S,Gümüş,Ersin,Demir,Hülya,Yüce,Aysel,Özen,Seza,Ahluwalia,Jasmina,Bharti,Bhavneet,Rajpal,Sweta,Uppal,Varun,Walia,Alaknanda,Samlok,Surjit S,Kumar,Narender,Valões,Clarissa C,Molinari,Beatriz C,Pitta,Ana Claudia G,Gormezano,Natali W,Farhat,Sylvia C,Kozu,Kátia,Sallum,Adriana M,Appenzeller,Simone,Sakamoto,Ana Paula,Terreri,Maria T,Pereira,Rosa M,Magalhães,Claudia S,Barbosa,Cássia Maria,Gomes,Francisco Hugo,Bonfá,Eloisa,Silva,Clovis A,Ozturk,Kubra,Ekinci,Zelal,Helal,Maie,Cabrera,Natalia,Belot,Alexandre,Lega,Jean Christophe,Drai,Jocelyne,Ecochard,Rene,Shpitonkova,O V,Podchernyaeva,N S,Kostina,Y O,Dashkova,N G,Osminina,M K,Yucel,Gozde,Sahin,Sezgin,Adrovic,Amra,Barut,Kenan,Tarakci,Ela,Arvas,Ahmet,Moorthy,Nandini,Kasapcopur,Ozgur,Dimou,Paraskevi,Midgley,Angela,Peak,Matthew,Satchell,Simon C,Wright,Rachael D,Beresford,Michael W,Corkhill,Rachel,Smith,Eve M,Beresford,Michael W,Bhattad,Sagar,Rawat,Amit,Singh,Surjit,Gupta,Anju,Suri,Deepti,de Boer,Martin,Kuijpers,Taco,Bhattad,Sagar,Rawat,Amit,Gupta,Anju,Suri,Deepti,Pandiarajan,Vignesh,Singh,Surjit,Sandal,Sapna,Rawat,Amit,Gupta,Anju,Singh,Surjit,Giraldo,Sebastian,Sanguino,Roy,Diaz,Adriana S,Uzuner,Selcuk,Sahin,Sezgin,Durcan,Gizem,Adrovic,Amra,Barut,Kenan,Kilicoglu,Ali Guven,Bilgic,Ayhan,Bahali,Kayhan,Kasapcopur,Ozgur,Sahin,Sezgin,Adrovic,Amra,Barut,Kenan,Durmus,Sinem,Uzun,Hafize,Kasapcopur,Ozgur,Sahin,Sezgin,Adrovic,Amra,Barut,Kenan,Canpolat,Nur,Caliskan,Salim,Sever,Lale,Kasapcopur,Ozgur,Sato,Tomomi,Kimura,Fuminori,Suwairi,Wafaa,Abdwani,Reem,Al Rowais,Abdulaziz,Al qanatish,Jubran,Al Asiri,Abdulrahman,Ozturk,Kubra,Ekinci,Zelal,Gaidar,Ekaterina,Kostik,Mikhail,Dubko,Margarita,Masalova,Vera,Serogodskaya,Elena,Snegireva,Ludmila,Nikitina,Tatyana,Chasnyk,Vyacheslav,Kalashnikova,Olga,Isupova,Evgenia,Sardar,Elham,Dusser,Perrine,Rousseau,Antoine,Labetoulle,Marc,Barreau,Emanuel,Bodaghi,Bahram,Kone-Paut,Isabelle,Foeldvari,Ivan,Anton,Jordi,Bou,Rosa,Angeles-Han,Sheila,Bangsgaard,Regitze,Brumm,Gabriele,Constantin,Tamas,Edelsten,Clive,Klotsche,Jens,Minden,Kirsten,Miserocchi,Elisabetta,Nielsen,Susan,Simonini,Gabriele,Heiligenhaus,Arnd,Foeldvari,Ivan,Anton,Jordi,Bou,Rosa,Angeles-Han,Sheila,Bangsgaard,Regitze,Brumm,Gabriele,Constantin,Tamas,Edelsten,Clive,Klotsche,Jens,Minden,Kirsten,Miserocchi,Elisabetta,Nielsen,Susan,Simonini,Gabriele,Heiligenhaus,Arnd,Foeldvari,Ivan,Anton,Jordi,Bou,Rosa,Angeles-Han,Sheila,Bangsgaard,Regitze,Brumm,Gabriele,Constantin,Tamas,Edelsten,Clive,Klotsche,Jens,Minden,Kirsten,Miserocchi,Elisabetta,Nielsen,Susan,Simonini,Gabriele,Heiligenhaus,Arnd,Foeldvari,Ivan,Anton,Jordi,Bou,Rosa,Angeles-Han,Sheila,Bangsgaard,Regitze,Brumm,Gabriele,Constantin,Tamas,Edelsten,Clive,Klotsche,Jens,Minden,Kirsten,Miserocchi,Elisabetta,Nielsen,Susan,Simonini,Gabriele,Heiligenhaus,Arnd,Angarita,Juan Manuel Mosquera,Bou,Rosa,de Vicuña,Carmen Garcia,Hernandez,Maria Victoria,Adan,Alfredo,Llorens,Victor,Alcobendas,Rosa,Noval,Susana,Robledillo,Juan Carlos Lopez,Valls,Isabel,Pinedo,Mari Carmen,Fonollosa,Alejandro,de Inocencio,Jaime,Tejada,Pilar,Bravo,Beatriz,Torribio,Manuel,de Yebenes,María Jesús García,Antón,Jordi,Argolini,Lorenza Maria,Pontikaki,Irene,Borghi,Maria Orietta,Cesana,Laura,Miserocchi,Elisabetta,Castiglioni,Barbara,Gattinara,Maurizio,Meroni,Pierluigi,Quartier,Pierre,Despert,Veronique,Poignant,Sylvaine,Baptiste,Amandine,Elie,Caroline,Kone-Paut,Isabelle,Belot,Alexandre,Kodjikian,Laurent,Monnet,Dominique,Weber,Michel,Bodaghi,Bahram,Moal,Laura,Rousseau,Antoine,Pham,LuuLy,Barreau,Emmanuel,Titah,Cherif,Dureau,Pascal,Labetoulle,Marc,Bodaghi,Bahram,Czitrom,Severine Guillaume,Cecchin,Vanessa,Zannin,Maria Elisabetta,Ferrari,Daniele,Comacchio,Francesco,Pontikaki,Irene,Bracaglia,Claudia,Cimaz,Rolando,Falcini,Fernanda,Petaccia,Antonella,Viola,Stefania,Breda,Luciana,La Torre,Francesco,Vittadello,Fabio,Martini,Giorgia,Zulian,Francesco,Galeotti,Caroline,Sarrabay,Guillaume,Fogel,Olivier,Touitou,Isabelle,Bodaghi,Bahram,Miceli-Richard,Corinne,Koné-Paut,Isabelle,Etayari,Hala,Soad,Hashad,El Kadry,Ihab,Eatamadi,Habibullah,AlAlgawi,Kais,Al Maini,Mustafa,Khawaja,Khulood,Van den Berghe,Sophie,de Schryver,Ilse,Raes,Ann,Joos,Rik,Dehoorne,Joke,Teixeira,Lídia L C,Duarte,Ana,Sousa,Sandra,Vinagre,Filipe,Santos,Maria J,Shevchenko,Nataly S,Bogmat,Ludmila F,Demyanenko,Marina V,Ramchurn,Navdha R,Friswell,Mark,James,Rebecca A,Wedderburn,Lucy R,Edelsten,Clive,Pattani,Reshma,Pilkington,Clarissa A,Compeyrot-Lacassagne,Sandrine,James,Rebecca A,Compeyrot-Lacassagne,Sandrine,Edelsten,Clive,Pattani,Reshma,Pilkington,Clarissa A,Wedderburn,Lucy R,Villarreal,Ana V,Acevedo,Nydia,Faugier,Enrique,Maldonado,Rocio,Yılmaz,Dilek,Uysal,Hilal Bektaş,Fedorov,Evgeny,Salugina,Svetlana,Kamenets,Elena,Zaharova,Ekaterina,Radenska-Lopovok,Stefka,Nascimento,Joao,Sofia,Helena,Zilhão,Carla,Almeida,Rui,Guedes,Margarida,Ozturk,Kubra,Deveci,Murat,Ekinci,Zelal,Rodionovskaya,Svetlana,Vinnikova,Vera,Salugina,Svetlana,Fedorov,Evgeny,Tsymbal,Irina,Olesińska,Edyta,Postępski,Jacek,Mroczkowska-Juchkiewicz,Agnieszka,Pawłowska-Kamieniak,Agnieszka,Chrapko,Beata,Ključevšek,Damjana,Emeršič,Nina,Toplak,Nataša,Avčin,Tadej,Rokhlina,Faina,Glazyrina,Galina,Kolyadina,Natalia,Kim,Kwangnam,Eom,Sinae,Kim,Daeyoung,Rhim,Jungwoo,Ricci,Francesca,Montesano,Paola,Bonafini,Barbara,Medeghini,Veronica,Parissenti,Ilaria,Meini,Antonella,Cattalini,Marco,Airò,Paolo,Panko,Nataliya,Shevchenko,Nataliya,Lebec,Iryna,Zajceva,Yevgeniya,Rostlund,Sara,André,Marie,Hara,Takuma,Kishi,Takayuki,Tani,Yumi,Hanaya,Aki,Miyamae,Takako,Nagata,Satoru,Yamanaka,Hisashi,Selmanovic,Velma,Omercahic-Dizdarevic,Aida,Cengic,Adisa,Cosickic,Almira,Dizdarević,Aida Omerčahić,Lepri,Gemma,Picco,Paolo,Malattia,Clara,Bellucci,Eleonora,Matucci-Cerinic,Marco,Falcini,Fernanda,Dubko,Margarita,Solovyev,Anton,Fedotova,Elena,Maldonado,Rocio,Faugier,Enrique,Villarreal,Ana Victoria,Acevedo,Nydia,Diaz,Talia,Ramirez,Yuridiana,Giani,Teresa,Marino,Achille,Simonini,Gabriele,Cimaz,Rolando,Hunt,Daniel,Al Obaidi,Muthana,Veli,Veli,Papadopoulou,Charalampia,Kammermeier,Jochen,Olesińska,Edyta,Poluha,Anna,Postępski,Jacek,Bharmappanavara,Gangadhara C,Kelly,Alison,Shaw,Lindsay,Giani,Teresa,Ferrara,Giovanna,Luzzati,Michele,Marino,Achille,Giovannini,Mattia,Simonini,Gabriele,Cimaz,Rolando,Jurado,Liliana,Giraldo,Sebastian,Chamorro,Juliana,Sarmiento,Lorena,Diaz,Adriana S,Medeghini,Veronica,Ricci,Francesca,Montesano,Paola,Bonafini,Barbara,Parissenti,Ilaria,Meini,Antonella,Conversano,Ester,Cattalini,Marco,Gicchino,Maria Francesca,Macchini,Giulia,Granato,Carmela,Tirelli,Assunta,Olivieri,Alma N,Perica,Marija,Bukovac,Lana Tambić,Bogmat,Ludmila F,Shevchenko,Nataly S,Demyanenko,Marina V,Sinaei,Reza,Parvaneh,Vadood Javadi,Shiari,Reza,Rahmani,Khosro,Mehregan,Fatemeh F,Yeganeh,Mehrnoush Hassas,Penadés,Inmaculada Calvo,Montesinos,Berta López,Fernández,Ma Isabel González,Vidal,Adriana Rodríguez,Rao,Anand Prahalad,Romana,Ayesha,Raghuram,Jyothi,Kumar,Ankur,Suri,Deepti,Gupta,Vishali,Rawat,Amit,Singh,Surjit,Comak,Elif,Aksoy,Gülşah Kaya,Yılmaz,Aygen,Atalay,Atike,Koyun,Mustafa,Artan,Reha,Akman,Sema,Gicchino,Maria Francesca,Macchini,Giulia,Granato,Carmela,Olivieri,Alma N,Kaleda,Maria I,Nikishina,Irina P,Soloviev,Sergei K,Malievsky,Victor A,Nikolaeva,Ekaterina V,Giani,Teresa,Marino,Achille,Simonini,Gabriele,Cimaz,Rolando,Gazda,Agnieszka,Kołodziejczyk,Beata,Rutkowska-Sak,Lidia,Mauro,Angela,Giani,Teresa,Simonini,Gabriele,Cimaz,Rolando,Gicchino,Maria Francesca,Marzuillo,Pierluigi,Guarino,Stefano,Olivieri,Alma N,La Manna,Angela
期刊：Thorax影响因子：7.700
时间：2017起止号：2017;15(Suppl 1):1022-4
doi：10.1136/thx.49.10.1022

Abstract

BACKGROUND: Nedocromil sodium, a nonsteroidal anti-inflammatory drug, is effective in the treatment of asthma. Its efficacy in the treatment of chronic obstructive pulmonary disease (COPD) has not been investigated. METHODS: Fifty four non-allergic patients with COPD were randomised to 10 weeks of treatment with placebo or nedocromil sodium (4 x 8 mg/day) in a double blind study. RESULTS: Nedocromil sodium treatment had no effect on airway responsiveness to histamine, methacholine, and adenosine-5'-monophosphate, pulmonary function, and symptom scores. Both patients and clinicians favoured treatment with nedocromil sodium, however, and the number of dropouts (because of exacerbations) was fewer during treatment with the drug. CONCLUSIONS: Longer trials will be necessary to assess if nedocromil sodium can reduce the frequency of exacerbations and the decrease in pulmonary function, eventually leading to a better quality of life in patients with COPD.

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