用户现在提供的是期刊针对原始研究发布的关注声明（Editorial Expression of Concern），并非原始研究文献，因此解析将围绕该声明的核心议题（动物伦理审批报告问题）展开，严格遵循要求格式输出：
1. 领域背景与文献
核心信息段：文献英文标题：Co-encapsulation of HNF4α overexpressing UMSCs and human primary hepatocytes ameliorates mouse acute liver failure;
发表期刊：Stem Cell Research & Therapy；影响因子：7.3；研究领域：干细胞生物学与急性肝衰竭治疗
急性肝衰竭是一种进展迅速的致命性肝脏疾病，临床病死率高，肝移植是唯一根治性手段，但供体短缺严重限制其应用。领域共识：脐带间充质干细胞（UMSCs）因具有免疫调节、多向分化潜能及低免疫原性，成为肝病细胞治疗的热门种子细胞；肝细胞核因子4α（HNF4α）是肝细胞分化及功能维持的关键转录因子，过表达HNF4α可促进UMSCs向肝细胞样细胞分化；细胞共封装技术是组织工程领域的重要策略，可提升细胞移植后的存活效率与功能稳定性，为急性肝衰竭的替代治疗提供新方向。
本关注声明针对上述原始研究的动物伦理审批报告问题发布，旨在提醒科研人员与读者谨慎解读该研究的伦理合规性相关信息，凸显了生命科学研究中伦理审批规范报告的重要性。
2. 文献综述解析
本声明为期刊官方发布的伦理关注类文件，不包含原始研究的文献综述内容，核心评述逻辑聚焦于原始研究的动物伦理审批报告缺陷。声明指出，原始研究中引用的伦理审批号SYXK 2008 0050为实验动物设施的通用许可，而非该研究的特定项目伦理审批；尽管作者后续提供了该研究单独获得伦理审批的证明文件，但原始论文中对伦理审批信息的报告不充分、不规范，不符合学术出版的伦理规范要求。
通过对比生命科学研究伦理报告的标准规范，本声明的核心价值在于强调动物实验研究中，必须明确标注针对具体研究项目的伦理审批文件信息，而非仅引用设施许可，这一要求是保障研究合规性、实验结果可追溯性的关键前提，也为同类研究的伦理报告提供了明确的规范指引。
3. 研究思路总结与详细解析
本关注声明不涉及原始研究的实验设计、方法及结果解析，仅针对伦理审批报告问题进行说明。原始研究的核心科学假设为：共封装过表达HNF4α的UMSCs与原代人肝细胞，可协同提升细胞在急性肝衰竭小鼠体内的存活与功能，进而改善小鼠的肝损伤状态；技术路线逻辑为“基因修饰细胞构建→细胞共封装→急性肝衰竭小鼠模型移植→肝功能评估”的经典转化研究闭环。
3.1 伦理审批报告问题说明
实验目的：核查原始研究的动物伦理审批合规性；
方法细节：期刊编辑部对原始研究中伦理审批信息的真实性、规范性进行追溯核查，要求作者补充提供研究特定的伦理审批文件；
结果解读：确认原始研究引用的审批号为设施通用许可，作者虽提供了单独审批文件，但原始报告未明确区分设施许可与项目审批，报告不规范；
产品关联：文献未提及具体实验产品，领域常规使用慢病毒载体用于基因修饰、海藻酸盐等材料用于细胞封装、生化检测试剂盒用于肝功能评估。
4. Biomarker研究及发现成果解析
本关注声明未涉及原始研究中生物标志物（Biomarker）的相关内容，仅聚焦伦理审批问题。推测：原始研究可能以血清谷丙转氨酶（ALT）、谷草转氨酶（AST）、总胆红素（TBIL）等肝功能指标作为疗效评估的Biomarker，也可能涉及肝细胞特异性蛋白（如白蛋白）、炎症因子等指标，但声明未提供相关数据，无法进行精准解析。
<img src="data:image/svg+xml;base64,PHN2ZyBoZWlnaHQ9IjgxIiB3aWR0aD0iNTciIHhtbG5zPSJodHRwOi8vd3d3LnczLm9yZy8yMDAwL3N2ZyI+PGcgZmlsbD0ibm9uZSIgZmlsbC1ydWxlPSJldmVub2RkIj48cGF0aCBkPSJtMTcuMzUgMzUuNDUgMjEuMy0xNC4ydi0xNy4wM2gtMjEuMyIgZmlsbD0iIzk4OTg5OCIvPjxwYXRoIGQ9Im0zOC42NSAzNS40NS0yMS4zLTE0LjJ2LTE3LjAzaDIxLjMiIGZpbGw9IiM3NDc0NzQiLz48cGF0aCBkPSJtMjggLjVjLTEyLjk4IDAtMjMuNSAxMC41Mi0yMy41IDIzLjVzMTAuNTIgMjMuNSAyMy41IDIzLjUgMjMuNS0xMC41MiAyMy41LTIzLjVjMC02LjIzLTIuNDgtMTIuMjEtNi44OC0xNi42Mi00LjQxLTQuNC0xMC4zOS02Ljg4LTE2LjYyLTYuODh6bTAgNDEuMjVjLTkuOCAwLTE3Ljc1LTcuOTUtMTcuNzUtMTcuNzVzNy45NS0xNy43NSAxNy43NS0xNy43NSAxNy43NSA3Ljk1IDE3Ljc1IDE3Ljc1YzAgNC43MS0xLjg3IDkuMjItNS4yIDEyLjU1cy03Ljg0IDUuMi0xMi41NSA1LjJ6IiBmaWxsPSIjNTM1MzUzIi8+PHBhdGggZD0ibTQxIDM2Yy01LjgxIDYuMjMtMTUuMjMgNy40NS0yMi40MyAyLjktNy4yMS00LjU1LTEwLjE2LTEzLjU3LTcuMDMtMjEuNWwtNC45Mi0zLjExYy00Ljk1IDEwLjctMS4xOSAyMy40MiA4Ljc4IDI5LjcxIDkuOTcgNi4zIDIzLjA3IDQuMjIgMzAuNi00Ljg2eiIgZmlsbD0iIzljOWM5YyIvPjxwYXRoIGQ9Im0uMiA1OC40NWMwLS43NS4xMS0xLjQyLjMzLTIuMDFzLjUyLTEuMDkuOTEtMS41Yy4zOC0uNDEuODMtLjczIDEuMzQtLjk0LjUxLS4yMiAxLjA2LS4zMiAxLjY1LS4zMi41NiAwIDEuMDYuMTEgMS41MS4zNS40NC4yMy44MS41IDEuMS44MWwtLjkxIDEuMDFjLS4yNC0uMjQtLjQ5LS40Mi0uNzUtLjU2LS4yNy0uMTMtLjU4LS4yLS41My0uMi0uMzkgMC0uNzMuMDgtMS4wNS4yMy0uMzEuMTYtLjU4LjM3LS44MS42Ni0uMjMuMjgtLjQxLjYzLS41MyAxLjA0LS4xMy40MS0uMTkuODgtLjE5IDEuMzkgMCAxLjA0LjIzIDEuODYuNjggMi40Ni40NS41OSAxLjA2Ljg4IDEuODQuODguNDEgMCAuNzctLjA3IDEuMDctLjIzcy41OS0uMzkuODUtLjY4bC45MSAxYy0uMzguNDMtLjguNzYtMS4yOC45OS0uNDcuMjItMSAuMzQtMS41OC4zNC0uNTkgMC0xLjEzLS4xLTEuNjQtLjMxLS41LS4yLS45NC0uNTEtMS4zMS0uOTEtLjM4LS40LS42Ny0uOS0uODgtMS40OC0uMjItLjU5LS4zMy0xLjI2LS4zMy0yLjAyem04LjQtNS4zM2gxLjYxdjIuNTRsLS4wNSAxLjMzYy4yOS0uMjcuNjEtLjUxLjk2LS43MnMuNzYtLjMxIDEuMjQtLjMxYy43MyAwIDEuMjcuMjMgMS42MS43MS4zMy40Ny41IDEuMTQuNSAyLjAydjQuMzFoLTEuNjF2LTQuMWMwLS41Ny0uMDgtLjk3LS4yNS0xLjIxLS4xNy0uMjMtLjQ1LS4zNS0uODMtLjM1LS4zIDAtLjU2LjA4LS43OS4yMi0uMjMuMTUtLjQ5LjM2LS43OC42NHY0LjhoLTEuNjF6bTcuMzcgNi40NWMwLS41Ni4wOS0xLjA2LjI2LTEuNTEuMTgtLjQ1LjQyLS44My43MS0xLjE0LjI5LS4zLjYzLS41NCAxLjAxLS43MS4zOS0uMTcuNzgtLjI1IDEuMTgtLjI1LjQ3IDAgLjg4LjA4IDEuMjMuNS4zNi4xNi42NS4zOC42NSAzOC42NSAzOC42NS0xMC41MiAyMy41LTIzLjVjMC02LjIzLTIuNDgtMTIuMjEtNi44OC0xNi42Mi00LjQxLTQuNC0xMC4zOS02Ljg4LTE2LjYyLTYuODh6bTAgNDEuMjVjLTkuOCAwLTE3Ljc1LTcuOTUtMTcuNzUtMTcuNzVzNy45NS0xNy43NSAxNy43NS0xNy43NSAxNy43NSA3Ljk1IDE3Ljc1IDE3Ljc1YzAgNC43MS0xLjg3IDkuMjItNS4yIDEyLjU1cy03Ljg0IDUuMi0xMi41NSA1LjJ6IiBmaWxsPSIjNTM1MzUzIi8+PHBhdGggZD0ibTQxIDM2Yy01LjgxIDYuMjMtMTUuMjMgNy40NS0yMi40MyAyLjktNy4yMS00LjU1LTEwLjE2LTEzLjU3LTcuMDMtMjEuNWwtNC45Mi0zLjExYy00Ljk1IDEwLjctMS4xOSAyMy40MiA4Ljc4IDI5LjcxIDkuOTcgNi4zIDIzLjA3IDQuMjIgMzAuNi00Ljg2eiIgZmlsbD0iIzljOWM5YyIvPjxwYXRoIGQ9Im0uMiA1OC40NWMwLS43NS4xMS0xLjQyLjMzLTIuMDFzLjUyLTEuMDkuOTEtMS41Yy4zOC0uNDEuODMtLjczIDEuMzQtLjk0LjUxLS4yMiAxLjA2LS4zMiAxLjY1LS4zMi41NiAwIDEuMDYuMTEgMS41MS4zNS40NC4yMy44MS41IDEuMS44MWwtLjkxIDEuMDFjLS4yNC0uMjQtLjQ5LS40Mi0uNzUtLjU2LS4yNy0uMTMtLjU4LS4yLS45My0uMi0uMzkgMC0uNzMuMDgtMS4wNS4yMy0uMzEuMTYtLjU4LjM3LS44MS42Ni0uMjMuMjgtLjQxLjYzLS41MyAxLjA0LS4xMy40MS0uMTkuODgtLjE5IDEuMzkgMCAxLjA0LjIzIDEuODYuNjggMi40Ni40NS41OSAxLjA2Ljg4IDEuODQuODguNDEgMCAuNzctLjA3IDEuMDctLjIzcy41OS0uMzkuODUtLjY4bC45MSAxYy0uMzguNDMtLjguNzYtMS4yOC45OS0uNDcuMjItMSAuMzQtMS41OC4zNC0uNTkgMC0xLjEzLS4xLTEuNjQtLjMxLS41LS4yLS45NC0uNTEtMS4zMS0uOTEtLjM4LS40LS42Ny0uOS0uODgtMS40OC0uMjItLjU5LS4zMy0xLjI2LS4zMy0yLjAyem04LjQtNS4zM2gxLjYxdjIuNTRsLS4wNSAxLjMzYy4yOS0uMjcuNjEtLjUxLjk2LS43MnMuNzYtLjMxIDEuMjQtLjMxYy43MyAwIDEuMjcuMjMgMS42MS43MS4zMy40Ny41IDEuMTQuNSAyLjAydjQuMzFoLTEuNjF2LTQuMWMwLS41Ny0uMDgtLjk3LS4yNS0xLjIxLS4xNy0uMjMtLjQ1LS4zNS0uODMtLjM1LS4zIDAtLjU2LjA4LS43OS4yMi0uMjMuMTUtLjQ5LjM2LS43OC42NHY0LjhoLTEuNjF6bTcuMzcgNi40NWMwLS41Ni4wOS0xLjA2LjI2LTEuNTEuMTgtLjQ1LjQyLS44My43MS0xLjE0LjI5LS4zLjYzLS41NCAxLjAxLS43MS4zOS0uMTcuNzgtLjI1IDEuMTgtLjI1LjQ3IDAgLjg4LjA4IDEuMjMuNS4zNi4xNi42NS4zOC42NSAzOC42NSAzOC42NS0xMC41MiAyMy41LTIzLjVjMC02LjIzLTIuNDgtMTIuMjEtNi44OC0xNi42Mi00LjQxLTQuNC0xMC4zOS02Ljg4LTE2LjYyLTYuODh6bTAgNDEuMjVjLTkuOCAwLTE3Ljc1LTcuOTUtMTcuNzUtMTcuNzVzNy45NS0xNy43NSAxNy43NS0xNy43NSAxNy43NSA3Ljk1IDE3Ljc1IDE3Ljc1YzAgNC43MS0xLjg3IDkuMjItNS4yIDEyLjU1cy03Ljg0IDUuMi0xMi41NSA1LjJ6IiBmaWxsPSIjNTM1MzUzIi8+PHBhdGggZD0ibTQxIDM2Yy01LjgxIDYuMjMtMTUuMjMgNy40NS0yMi40MyAyLjktNy4yMS00LjU1LTEwLjE2LTEzLjU3LTcuMDMtMjEuNWwtNC45Mi0zLjExYy00Ljk1IDEwLjctMS4xOSAyMy40MiA4Ljc4IDI5LjcxIDkuOTcgNi4zIDIzLjA3IDQuMjIgMzAuNi00Ljg2eiIgZmlsbD0iIzljOWM5YyIvPjxwYXRoIGQ9Im0uMiA1OC40NWMwLS43NS4xMS0xLjQyLjMzLTIuMDFzLjUyLTEuMDkuOTEtMS41Yy4zOC0uNDEuODMtLjczIDEuMzQtLjk0LjUxLS4yMiAxLjA2LS4zMiAxLjY1LS4zMi41NiAwIDEuMDYuMTEgMS41MS4zNS40NC4yMy44MS41IDEuMS44MWwtLjkxIDEuMDFjLS4yNC0uMjQtLjQ5LS40Mi0uNzUtLjU2LS4yNy0uMTMtLjU4LS4yLS45My0uMi0uMzkgMC0uNzMuMDgtMS4wNS4yMy0uMzEuMTYtLjU4LjM3LS44MS42Ni0uMjMuMjgtLjQxLjYzLS41MyAxLjA0LS4xMy40MS0uMTkuODgtLjE5IDEuMzkgMCAxLjA0LjIzIDEuODYuNjggMi40Ni40NS41OSAxLjA2Ljg4IDEuODQuODguNDEgMCAuNzctLjA3IDEuMDctLjIzcy41OS0uMzkuODUtLjY4bC45MSAxYy0uMzguNDMtLjguNzYtMS4yOC45OS0uNDcuMjItMSAuMzQtMS41OC4zNC0uNTkgMC0xLjEzLS4xLTEuNjQtLjMxLS41LS4yLS45NC0uNTEtMS4zMS0uOTEtLjM4LS40LS42Ny0uOS0uODgtMS40OC0uMjItLjU5LS4zMy0xLjI2LS4zMy0yLjAyem04LjQtNS4zM2gxLjYxdjIuNTRsLS4wNSAxLjMzYy4yOS0uMjcuNjEtLjUxLjk2LS43MnMuNzYtLjMxIDEuMjQtLjMxYy43MyAwIDEuMjcuMjMgMS42MS43MS4zMy40Ny41IDEuMTQuNSAyLjAydjQuMzFoLTEuNjF2LTQuMWMwLS41Ny0uMDgtLjk3LS4yNS0xLjIxLS4xNy0uMjMtLjQ1LS4zNS0uODMtLjM1LS4zIDAtLjU2LjA4LS43OS4yMi0uMjMuMTUtLjQ5LjM2LS43OC42NHY0LjhoLTEuNjF6bTcuMzcgNi40NWMwLS41Ni4wOS0xLjA2LjI2LTEuNTEuMTgtLjQ1LjQyLS44My43MS0xLjE0LjI5LS4zLjYzLS41NCAxLjAxLS43MS4zOS0uMTcuNzgtLjI1IDEuMTgtLjI1LjQ3IDAgLjg4LjA4IDEuMjMuNS4zNi4xNi42NS4zOC42NSAzOC42NSAzOC42NS0xMC41MiAyMy41LTIzLjVjMC02LjIzLTIuNDgtMTIuMjEtNi44OC0xNi42Mi00LjQxLTQuNC0xMC4zOS02Ljg4LTE2LjYyLTYuODh6bTAgNDEuMjVjLTkuOCAwLTE3Ljc1LTcuOTUtMTcuNzUtMTcuNzVzNy45NS0xNy43NSAxNy43NS0xNy43NSAxNy43NSA3Ljk1IDE3Ljc1IDE3Ljc1YzAgNC43MS0xLjg3IDkuMjItNS4yIDEyLjU1cy03Ljg0IDUuMi0xMi41NSA1LjJ6IiBmaWxsPSIjNTM1MzUzIi8+PHBhdGggZD0ibTQxIDM2Yy01LjgxIDYuMjMtMTUuMjMgNy40NS0yMi40MyAyLjktNy4yMS00LjU1LTEwLjE2LTEzLjU3LTcuMDMtMjEuNWwtNC45Mi0zLjExYy00Ljk1IDEwLjctMS4xOSAyMy40MiA4Ljc4IDI5LjcxIDkuOTcgNi4zIDIzLjA3IDQuMjIgMzAuNi00Ljg2eiIgZmlsbD0iIzljOWM5YyIvPjxwYXRoIGQ9Im0uMiA1OC40NWMwLS43NS4xMS0xLjQyLjMzLTIuMDFzLjUyLTEuMDkuOTEtMS41Yy4zOC0uNDEuODMtLjczIDEuMzQtLjk0LjUxLS4yMiAxLjA2LS4zMiAxLjY1LS4zMi41NiAwIDEuMDYuMTEgMS41MS4zNS40NC4yMy44MS41IDEuMS44MWwtLjkxIDEuMDFjLS4yNC0uMjQtLjQ5LS40Mi0uNzUtLjU2LS4yNy0uMTMtLjU4LS4yLS45My0uMi0uMzkgMC0uNzMuMDgtMS4wNS4yMy0uMzEuMTYtLjU4LjM3LS44MS42Ni0uMjMuMjgtLjQxLjYzLS41MyAxLjA0LS4xMy40MS0uMTkuODgtLjE5IDEuMzkgMCAxLjA0LjIzIDEuODYuNjggMi40Ni40NS41OSAxLjA2Ljg4IDEuODQuODguNDEgMCAuNzctLjA3IDEuMDctLjIzcy41OS0uMzkuODUtLjY4bC45MSAxYy0uMzguNDMtLjguNzYtMS4yOC45OS0uNDcuMjItMSAuMzQtMS41OC4zNC0uNTkgMC0xLjEzLS4xLTEuNjQtLjMxLS41LS4yLS45NC0uNTEtMS4zMS0uOTEtLjM4LS40LS42Ny0uOS0uODgtMS40OC0uMjItLjU5LS4zMy0xLjI2LS4zMy0yLjAyem04LjQtNS4zM2gxLjYxdjIuNTRsLS4wNSAxLjMzYy4yOS0uMjcuNjEtLjUxLjk2LS43MnMuNzYtLjMxIDEuMjQtLjMxYy43MyAwIDEuMjcuMjMgMS42MS43MS4zMy40Ny41IDEuMTQuNSAyLjAydjQuMzFoLTEuNjF2LTQuMWMwLS41Ny0uMDgtLjk3LS4yNS0xLjIxLS4xNy0uMjMtLjQ1LS4zNS0uODMtLjM1LS4zIDAtLjU2LjA4LS43OS4yMi0uMjMuMTUtLjQ5LjM2LS43OC42NHY0LjhoLTEuNjF6bTcuMzcgNi40NWMwLS41Ni4wOS0xLjA2LjI2LTEuNTEuMTgtLjQ1LjQyLS44My43MS0xLjE0LjI5LS4zLjYzLS41NCAxLjAxLS43MS4zOS0uMTcuNzgtLjI1IDEuMTgtLjI1LjQ3IDAgLjg4LjA4IDEuMjMuNS4zNi4xNi42NS4zOC42NSAzOC42NSAzOC42NS0xMC41MiAyMy41LTIzLjVjMC02LjIzLTIuNDgtMTIuMjEtNi44OC0xNi42Mi00LjQxLTQuNC0xMC4zOS02Ljg4LTE2LjYyLTYuODh6bTAgNDEuMjVjLTkuOCAwLTE3Ljc1LTcuOTUtMTcuNzUtMTcuNzVzNy45NS0xNy43NSAxNy43NS0xNy43NSAxNy43NSA3Ljk1IDE3Ljc1IDE3Ljc1YzAgNC43MS0xLjg3IDkuMjItNS4yIDEyLjU1cy03Ljg0IDUuMi0xMi41NSA1LjJ6IiBmaWxsPSIjNTM1MzUzIi8+PHBhdGggZD0ibTQxIDM2Yy01LjgxIDYuMjMtMTUuMjMgNy40NS0yMi40MyAyLjktNy4yMS00LjU1LTEwLjE2LTEzLjU3LTcuMDMtMjEuNWwtNC45Mi0zLjExYy00Ljk1IDEwLjctMS4xOSAyMy40MiA4Ljc4IDI5LjcxIDkuOTcgNi4zIDIzLjA3IDQuMjIgMzAuNi00Ljg2eiIgZmlsbD0iIzljOWM5YyIvPjxwYXRoIGQ9Im0uMiA1OC40NWMwLS43NS4xMS0xLjQyLjMzLTIuMDFzLjUyLTEuMDkuOTEtMS41Yy4zOC0uNDEuODMtLjczIDEuMzQtLjk0LjUxLS4yMiAxLjA2LS4zMiAxLjY1LS4zMi41NiAwIDEuMDYuMTEgMS41MS4zNS40NC4yMy44MS41IDEuMS44MWwtLjkxIDEuMDFjLS4yNC0uMjQtLjQ5LS40Mi0uNzUtLjU2LS4yNy0uMTMtLjU4LS4yLS45My0uMi0uMzkgMC0uNzMuMDgtMS4wNS4yMy0uMzEuMTYtLjU4LjM3LS44MS42Ni0uMjMuMjgtLjQxLjYzLS41MyAxLjA0LS4xMy40MS0uMTkuODgtLjE5IDEuMzkgMCAxLjA0LjIzIDEuODYuNjggMi40Ni40NS41OSAxLjA2Ljg4IDEuODQuODguNDEgMCAuNzctLjA3IDEuMDctLjIzcy41OS0uMzkuODUtLjY4bC45MSAxYy0uMzguNDMtLjguNzYtMS4yOC45OS0uNDcuMjItMSAuMzQtMS41OC4zNC0uNTkgMC0xLjEzLS4xLTEuNjQtLjMxLS41LS4yLS45NC0uNTEtMS4zMS0uOTEtLjM4LS40LS42Ny0uOS0uODgtMS40OC0uMjItLjU5LS4zMy0xLjI2LS4zMy0yLjAyem04LjQtNS4zM2gxLjYxdjIuNTRsLS4wNSAxLjMzYy4yOS0uMjcuNjEtLjUxLjk2LS43MnMuNzYtLjMxIDEuMjQtLjMxYy43MyAwIDEuMjcuMjMgMS42MS43MS4zMy40Ny41IDEuMTQuNSAyLjAydjQuMzFoLTEuNjF2LTQuMWMwLS41Ny0uMDgtLjk3LS4yNS0xLjIxLS4xNy0uMjMtLjQ1LS4zNS0uODMtLjM1LS4zIDAtLjU2LjA4LS43OS4yMi0uMjMuMTUtLjQ5LjM2LS43OC42NHY0LjhoLTEuNjF6bTcuMzcgNi40NWMwLS41Ni4wOS0xLjA2LjI2LTEuNTEuMTgtLjQ1LjQyLS44My43MS0xLjE0LjI5LS4zLjYzLS41NCAxLjAxLS43MS4zOS0uMTcuNzgtLjI1IDEuMTgtLjI1LjQ3IDAgLjg4LjA4IDEuMjMuNS4zNi4xNi42NS4zOC42NSAzOC42NSAzOC42NS0xMC41MiAyMy41LTIzLjVjMC02LjIzLTIuNDgtMTIuMjEtNi44OC0xNi42Mi00LjQxLTQuNC0xMC4zOS02Ljg4LTE2LjYyLTYuODh6bTAgNDEuMjVjLTkuOCAwLTE3Ljc1LTcuOTUtMTcuNzUtMTcuNzVzNy45NS0xNy43NSAxNy43NS0xNy43NSAxNy43NSA3Ljk1IDE3Ljc1IDE3Ljc1YzAgNC43MS0xLjg3IDkuMjItNS4yIDEyLjU1cy03Ljg0IDUuMi0xMi41NSA1LjJ6IiBmaWxsPSIjNTM1MzUzIi8+PHBhdGggZD0ibTQxIDM2Yy01LjgxIDYuMjMtMTUuMjMgNy40NS0yMi40MyAyLjktNy4yMS00LjU1LTEwLjE2LTEzLjU3LTcuMDMtMjEuNWwtNC45Mi0zLjExYy00Ljk1IDEwLjctMS4xOSAyMy40MiA4Ljc4IDI5LjcxIDkuOTcgNi4zIDIzLjA3IDQuMjIgMzAuNi00Ljg2eiIgZmlsbD0iIzljOWM5YyIvPjxwYXRoIGQ9Im0uMiA1OC40NWMwLS43NS4xMS0xLjQyLjMzLTIuMDFzLjUyLTEuMDkuOTEtMS41Yy4zOC0uNDEuODMtLjczIDEuMzQtLjk0LjUxLS4yMiAxLjA2LS4zMiAxLjY1LS4zMi41NiAwIDEuMDYuMTEgMS41MS4zNS40NC4yMy44MS41IDEuMS44MWwtLjkxIDEuMDFjLS4yNC0uMjQtLjQ5LS40Mi0uNzUtLjU2LS4yNy0uMTMtLjU4LS4yLS45My0uMi0uMzkgMC0uNzMuMDgtMS4wNS4yMy0uMzEuMTYtLjU4LjM3LS44MS42Ni0uMjMuMjgtLjQxLjYzLS41MyAxLjA0LS4xMy40MS0uMTkuODgtLjE5IDEuMzkgMCAxLjA0LjIzIDEuODYuNjggMi40Ni40NS41OSAxLjA2Ljg4IDEuODQuODguNDEgMCAuNzctLjA3IDEuMDctLjIzcy41OS0uMzkuODUtLjY4bC45MSAxYy0uMzguNDMtLjguNzYtMS4yOC45OS0uNDcuMjItMSAuMzQtMS41OC4zNC0uNTkgMC0xLjEzLS4xLTEuNjQtLjMxLS41LS4yLS45NC0uNTEtMS4zMS0uOTEtLjM4LS40LS42Ny0uOS0uODgtMS40OC0uMjItLjU5LS4zMy0xLjI2LS4zMy0yLjAyem04LjQtNS4zM2gxLjYxdjIuNTRsLS4wNSAxLjMzYy4yOS0uMjcuNjEtLjUxLjk2LS43MnMuNzYtLjMxIDEuMjQtLjMxYy43MyAwIDEuMjcuMjMgMS42MS43MS4zMy40Ny41IDEuMTQuNSAyLjAydjQuMzFoLTEuNjF2LTQuMWMwLS41Ny0uMDgtLjk3LS4yNS0xLjIxLS4xNy0uMjMtLjQ1LS4zNS0uODMtLjM1LS4zIDAtLjU2LjA4LS43OS4yMi0uMjMuMTUtLjQ5LjM2LS43OC42NHY0LjhoLTEuNjF6bTcuMzcgNi40NWMwLS41Ni4wOS0xLjA2LjI2LTEuNTEuMTgtLjQ1LjQyLS44My43MS0xLjE0LjI5LS4zLjYzLS41NCAxLjAxLS43MS4zOS0uMTcuNzgtLjI1IDEuMTgtLjI1LjQ3IDAgLjg4LjA4IDEuMjMuNS4zNi4xNi42NS4zOC42NSAzOC42NSAzOC42NS0xMC41MiAyMy41LTIzLjVjMC02LjIzLTIuNDgtMTIuMjEtNi44OC0xNi42Mi00LjQxLTQuNC0xMC4zOS02Ljg4LTE2LjYyLTYuODh6bTAgNDEuMjVjLTkuOCAwLTE3Ljc1LTcuOTUtMTcuNzUtMTcuNzVzNy45NS0xNy43NSAxNy43NS0xNy43NSAxNy43NSA3Ljk1IDE3Ljc1IDE3Ljc1YzAgNC43MS0xLjg3IDkuMjItNS4yIDEyLjU1cy03Ljg0IDUuMi0xMi41NSA1LjJ6IiBmaWxsPSIjNTM1MzUzIi8+PHBhdGggZD0ibTQxIDM2Yy01LjgxIDYuMjMtMTUuMjMgNy40NS0yMi40MyAyLjktNy4yMS00LjU1LTEwLjE2LTEzLjU3LTcuMDMtMjEuNWwtNC45Mi0zLjExYy00Ljk1IDEwLjctMS4xOSAyMy40MiA4Ljc4IDI5LjcxIDkuOTcgNi4zIDIzLjA3IDQuMjIgMzAuNi00Ljg2eiIgZmlsbD0iIzljOWM5YyIvPjxwYXRoIGQ9Im0uMiA1OC40NWMwLS43NS4xMS0xLjQyLjMzLTIuMDFzLjUyLTEuMDkuOTEtMS41Yy4zOC0uNDEuODMtLjczIDEuMzQtLjk0LjUxLS4yMiAxLjA2LS4zMiAxLjY1LS4zMi41NiAwIDEuMDYuMTEgMS41MS4zNS40NC4yMy44MS41IDEuMS44MWwtLjkxIDEuMDFjLS4yNC0uMjQtLjQ5LS40Mi0uNzUtLjU2LS4yNy0uMTMtLjU4LS4yLS45My0uMi0uMzkgMC0uNzMuMDgtMS4wNS4yMy0uMzEuMTYtLjU4LjM3LS44MS42Ni0uMjMuMjgtLjQxLjYzLS41MyAxLjA0LS4xMy40MS0uMTkuODgtLjE5IDEuMzkgMCAxLjA0LjIzIDEuODYuNjggMi40Ni40NS41OSAxLjA2Ljg4IDEuODQuODguNDEgMCAuNzctLjA3IDEuMDctLjIzcy41OS0uMzkuODUtLjY4bC45MSAxYy0uMzguNDMtLjguNzYtMS4yOC45OS0uNDcuMjItMSAuMzQtMS41OC4zNC0uNTkgMC0xLjEzLS