Growth inhibition and growth stimulation by estradiol of estrogen receptor transfected human breast epithelial cell lines involve different pathways

雌二醇对转染雌激素受体的乳腺上皮细胞系的生长抑制和生长刺激涉及不同的途径。

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作者：Olumi,A F,Grossfeld,G D,Hayward,S W,Carroll,P R,Tlsty,T D,Cunha,G R,Bartek,J,Lukas,C,Sørensen,C,Santoni-Rugiu,E,Bartkova,J,Lukas,J,Streuli,C,Gilmore,A,Metcalfe,A,Lee,Y-J,Oliver,J,Valentijn,A,Harris,AL,Nedelcheva Kristensen,V,Harada,N,Yoshimura,N,Haraldsen,E,Lønning,PE,Erikstein,B,Kåresen,R,Kristensen,T,Børresen-Dale,A-L,Martin,L-A,Chan,CMW,Marshall,C,Dowsett,M,Lowe,SW,Schmitt,CA,Ferbeyre,G,Lin,AW,de Stanchina,E,Soengas,M,Gatti,RA,Concannon,P,Díez,O,Pericay,C,Domènech,M,Brunet,J,Cortés,J,Balmaña,J,Gómez,A,López,JJ,Alonso,MC,Baiget,M,Kote-Jarai,Z,Powles,TP,Ashley,S,Easton,DF,Assersohn,L,Sodha,N,Dowsett,M,Gusterson,B,Tidy,A,Mitchell,G,Eeles,RA,Walker,PM,Foster,DM,Romaschin,AD,Harris,D,David,TE,Marshall,JC,Qing,Ma,Seghaye,MC,Vazquez,J,Grabitz,RG,Klosterhalfen,B,Sigler,M,Messmer,BJ,von Bernuth,G,van Zwienen,J,Voets,A,van der Linden,C,van Leeuwen,S,Hendriks,T,Doelman,C,Miederna,K,van der Starre,P,Haalebos,M,Bilo,H,van Rooijen-Butijn,W,Seghaye,MC,Grabitz,RG,Hövels-Gürich,HH,Duchateau,J,Däbritz,S,Messmer,BJ,von Bernuth,G,Ravn,HB,Ilkjaer,LB,Moeldrup,U,Jensen,L,Chew,M,Johnsen,S,Birk-Soerensen,L,Tønnesen,E,Hjortdal,VE,Birner,V,Ratheiser,K,Kranz,A,Zauner,Ch,Kramer,L,Schiefermeier,M,Gangl,A,Keh,D,Kürer,I,Gerlach,M,Dudenhausen,W,Woltmann,W,Falke,K,Gerlach,H,Ellis,AJ,Rhodes,A,Jackson,N,O'Grady,JG,Harrison,PM,Rela,M,Gibb,P,Heaton,N,Williams,R,Wendon,JA,Jenkins,DH,Frankel,HL,May,AK,Nguyen,H,Simo,K,Schwab,CW,Bina,S,Stylianos,V,loannis,K,Georgios,D,loannis,A,Antonios,K,Kyriakos,K,Emmanouil,A,Tesinsky,P,Rusavy,Z,Novak,I,Sramek,V,Mutzbauer,TS,Mueller,PHJ,Hatherill,M,Tibby,SM,Mclntyre,A,Murdoch,IA,Mure,M,Glenny,RW,Domino,KB,Hlastala,MP,Bertolissi,M,Bassi,F,Petrei,D,Giordano,F,Ahlers,O,Boehnke,T,Kerner,T,Deja,M,Keh,D,Löffel,J,Hildebrandt,B,Riess,H,Wust,P,Pappert,D,Gerlach,H,Servillo,G,De Robertis,E,Rossano,F,Tufano,R,Gauvin,F,Toledano,B,David,M,Lacroix,J,Levy,H,Ash,SR,Steczko,J,Carr,DJ,Russwurm,S,Wiederhold,M,Böhm,KJ,Mühlig,P,Stonans,I,Unger,E,Reinhart,K,Kehler,D,Tonnesen,E,Toft,P,Russwurm,S,Stonans,I,Stonane,E,Weigand,G,Wiederhold,M,Jäger,L,Reinhart,K,Honore,PM,Jamez,J,Wauthier,M,Dugernier,T,Kepka,A,Schabernig,C,Ihra,G,Kraincuk,P,Aloy,A,DaSilva,MC,Smith,JS,Cooney,RN,Bass,TL,Blosser,SA,Troncy,E,Francœur,M,Blaise,G,Vicente,R,López,LM,Ramos,F,Borro,JM,Morales,P,Montero,R,Esen,F,Friess,U,Quintel,M,van Ackern,K,Reinhart,K,Rieger,KM,Träger,K,Vlatten,A,Matejovic,M,Iber,T,Georgieff,M,Radermacher,P,Vangerow,B,Marx,G,Leuwer,M,Rueckoldt,H,Träger,K,Rieger,KM,Vlatten,A,Matejovic,M,Iber,T,Georgieff,M,Radermacher,P,Dohrn,B,Russwurm,S,Vickers,J,Meier-Hellmann,A,Spangenberg,P,Lösche,W,Reinhart,K,Vlatten,A,Träger,K,Rieger,KM,Iber,T,Matejovic,M,Steudle,M,Georgieff,M,Radermacher,P,Otomo,Y,Henmi,H,Honma,M,Kato,H,Inoue,J,Arai,T,Maruniak-Chudek,I,Œwietliñski,J,Homma,M,Henmi,H,Otomo,Y,Inoue,J,Kato,H,Arai,T,Haraldsen,P,Isaksson,K,Zdanowski,Z,Andersson,R,Hoshino,M,Haraguchi,Y,Sakai,M,Saegusa,H,Hayashi,K,Horita,N,Ohsawa,H,Castella,X,Torner,F,Ribera,L,Robusté,J,Polansky,M,Varon,J,Hoots,WK,Cohen,J,Avrahami,R,Singer,P,Zelikovski,A,Inthorn,D,Hoffmann,JN,Hartl,WH,Mühlbayer,D,Jochum,M,Rušavý,Z,Šrámek,V,Lacigová,S,TeŠínský,P,Novák,I,Rokyta,R,Kordová,H,Friess,U,Quintel,M,Roth,H,Esen,F,Beyer,C,Bender,HJ,Bauer,Ph,Charpentier,C,Bouchet,C,Raffy,F,Gaconnet,N,Larcan,A,Brix-Christensen,V,Liu,Y,Tonnesen,E,Stefano,G,Rödi,S,Zobel,G,Urlesberger,B,Ring,E,Kuttnig-Haim,M,Endo,S,Nakae,H,Yamada,Y,Inada,K,Taniguchi,S,Giles,LJ,Barber,AC,Creed,G,Ng,B,Beale,RJ,McLuckie,A,Bernal,W,Langley,P,Wendon,J,Van der Linden,T,Chieux,V,Cabaret,P,Forzy,G,Lepoutre,B,Dhondt,JL,Weiss,M,Selig,C,Ruoff,M,Feist,H,Karcher,C,Koch,A,Reuter,A,Schneider,EM,Roberts,PC,Boyle,NH,Barber,AC,Ng,B,McLuckie,A,Beale,RJ,Roth,H,Quintel,M,Tillmans,R,Lansche,G,Friess,U,Herrmann,P,Bender,HJ,Valenza,F,Sibilla,S,Porro,G,Nicolini,G,Tredici,G,Gattinoni,L,Crespo,AS,Carvalho,AF,Fernandes,MA,Campos,LA,Williams,RB,Peterson,BD,Gysbrechts,C,Dits,H,Frans,E,Michels,A,Wilmer,A,Van de Woestijne,KP,Bobbaers,H,Ruzicka,J,Nalos,M,Sramek,V,Novák,I,Rokyta,R,Matejovic,M,Hora,P,Agadganjan,VV,Kravtsov,SA,Kreines,VM,Novokshonov,AV,Burhop,K,Ince,C,Gulati,A,Malcolm,D,Tulli,G,Cellerini,A,Farese,A,Mangani,V,Oggioni,R,Zolfanelli,F,Stefanovski,T,Arsovski,Z,Balaban,G,Stahl,W,Calzia,E,Radermacher,P,Calzia,E,Stahl,W,Radermacher,P,Calzia,E,Handschuh,T,Stahl,W,Marx,T,Radermacher,P,Georgieff,M,Stahl,W,Handschuh,T,Calzia,E,Marx,T,Radermacher,P,Georgieff,M,Cakar,N,Tugrul,M,Demirarslan,A,Erdem,T,Akinci,Ö,Esen,F,Telci,L,Pettilä,V,Pettilä,M,Voutilainen,P,Takkunen,O,Livianu,J,Orlando,JMC,Maciel,FMB,Proença,JO,Park,JS,Kim,SH,Sheen,SS,Jeong,SM,Lee,YJ,Mueller,PHJ,Wachsmuth,C,Waschke,KF,Köppel,C,Fahron,G,Andrich-Heumann,B,Livianu,J,Orlando,JMC,Maciel,FMB,Anção,MS,Wey,SB,Akamine,N,Knobel,E,Ziser,A,Alkobi,M,Markovits,R,Rozenberg,B,van Zwienen,J,Voets,A,van Leeuwen,S,Hendriks,T,Doelman,C,Miedema,K,van der Starre,P,Haalebos,M,Bilo,H,van Rooijen-Butjin,W,Russwurm,S,Wiederhold,M,Stonans,I,Oberhoffer,M,Reinhart,K,Ruβwurm,S,Wiederhold,M,Stonans,I,Oberhoffer,M,Reinhart,K,Gleiβ,J,Düpree,HJ,Lewejohann,JC,Lewejohann,S,Bruch,H-P,Endo,S,Kasai,T,Koike,S,Yamada,Y,Inoue,Y,Taniguchi,S,Inada,K,Ikeda,K,Ikeda,T,Lobo,SMA,Meirelles,RF Jr,Lupino,P,Pires,MD,Kuga,ML,Beolchi,G,Schwarz,S,Bertram,M,Schwab,S,Andrassy,K,Hacke,W,Brunkhorst,FM,Wegscheider,K,Forycki,ZF,Brunkhorst,R,Kiessling,A-H,Isgro,F,Tran,K-H,Nagel,Saggau,W,Taneja,R,Li,Y,Parodo,J,Marshall,JC,Secchi,A,Ortanderl,M,Gebhard,MM,Martin,E,Schmidt H,H,Lorente,L,Cerdá,E,de la Cal,MA,Sánchez,M,Garcia,P,de la Torre-Prados,MV,Poullet-Brea,A,Soler-García,A,García-Alcántara,A,Reina-Artacho,C,Molina,JM,Ýyilikçi,L,Eyigör,C,Atay,A,Evliya,Ü,Koroðlu,N,Çelik,M,Günerli,A,Wehler,M,Strauβ,R,Kokoska,J,Müller,A,Meyer,M,Reulbach,U,Hahn,EG,Lichtenthal,PR,De Wolf,A,Verma,A,Phillips,M,Wendon,J,Bartola,A,Milheiro,R,Lafuente,E,Gonçalves,C,Fernandes,J,Leão,J,Sousa,A,Martins,M,Vieira,A,Jackson,N,Cookson,S,Bernal,W,Wendon,J,Donaldson,P,Parizkova,R,Dostal,P,Cerny,V,Rahman,TM,Selden,C,Hodgson,HJ,Luzzati,R,Todeschini,G,Amalfitano,G,Soldani,F,Franchini,M,Lazzarini,L,Grassi,A,Perona,G,Concia,E,Lamsch,P,Schwarz,R,Werner,M,Wenzke,M,Hauss,J,Camps,K,Jorens,PG,Demey,HE,Coen,H,Pattyn,SR,Goossens,H,Ieven,M,Rahman,TM,Phillips,M,Wendon,J,Kasal,K,Chytra,I,Štruncová,V,Bílek,M,DaSilva,MC,Gupta,M,Holman,MJ,Yang,HG,Conter,RL,Cooney,RN,Holland,PC,Hancock,SW,Thompson,D,Evans,SW,van der Voort,PHJ,van derr Hulst,RWM,Zandstra,DF,Geraedts,AAM,van der Ende,A,Tytgat,GNJ,Thalhammer,F,Traunmüller,F,Frass,M,Hollenstein,UM,Locker,GJ,Staudinger,T,Burgmann,H,Boyle,NH,Roberts,PC,McLuckie,A,Owen,WJ,Beale,RJ,Mason,RC,angerow,B,Häfner,D,Germann,P-G,Marx,G,Rueckoldt,H,Boyle,NH,Roberts,PC,McLuckie,A,Owen,WJ,Beale,RJ,Mason,RC,Beck,GC,Yard,BA,van der Woude,FJ,van Ackern,K,Fuchs,J,von Kleist,DH,Hann,J,Karaus,M,Cerny,V,Zivny,P,Dostal,P,Parizkova,R,Charlton,P,Jeffrey,H,Barrie,B,Vucevic,M,Lorente,L,de la Cal,MA,Cerdá,E,Garcia,P,Sánchez,M,Bawa,GPS,Morgan,TJ,Venkatesh,B,Palabiyikoglu,I,Tulunay,M,Asik,I,Oral,M,Unsal,M,Gungor,S,Bawa,GPS,Venkatesh,B,Morgan,TJ,van der Voort,PHJ,van deer Hulst,RWM,Zandstra,DF,Geraedts,AAM,Kesecioglu,J,Tytgat,GNJ,Ruggieri,CG,Cecchini,F,Donati,G,Morigi,A,Montanari,S,Sanseverino,M,Spedicato,S,Nastasi,M,Martinelli,G,Carsauw,H,Suetens,C,Jans,B,Dubau,B,Hernandez,V,Mary,F,Malbert,S,Botton,A,Winnock,S,Maurette,P,Gyurov,E,Milanov,M,Milanov,S,Donati,A,Coltrinari,R,Mercuri,G,Carletti,P,Conti,G,Loggi,S,Falcetta,S,Pelaia,P,Pietropaoli,P,Suetens,C,Jans,B,Carsauw,H,Ronveaux,O,Rashid,HI,van Heerden,N,Taylor,PR,Edmondson,RA,Morra,S,Laudi,C,Nespoli,F,Ferrario,M,Latino,M,Cecini,MT,Hernandez,J,DiTeodoro,A,Sturla,C,Toft,P,Tønnesen,E,Bendtzen,K,Ranta,V,Orpana,A,Carpén,O,Turpeinen,U,Ylikorkala,O,Viinikka,L,Cerny,V,Zivny,P,Dostal,P,Parizkova,R,Cobas Meyer,M,Marx,G,Vangerow,B,Heine,J,Leuwer,M,Piepenbrock,S,Rueckoldt,H,Ahlers,O,Boehnke,T,Kerner,T,Deja,M,Keh,D,Löffel,J,Hildebrandt,B,Riess,H,Wust,P,Pappert,D,Gerlach,H,Ruβwurm,S,Meissner,W,Stonans,I,Wiederhold,M,Stonane,E,Reinhart,K,Qing,M,Vazquez-Jimenez,JF,Klosterhalfen,B,Sigler,M,Messmer,BJ,von Bernuth,G,Seghaye,M-C,Andersson,R,Sun,Z,Wang,X,Lasson,Å,Börjesson,A,Ruβwurm,S,Dohrn,B,Oberhoffer,M,Meier-Hellmann,A,Krause,S,Lösche,W,Reinhart,K,Rizoli,S,Rotstein,O,Kapus,A,Wegermann,P,Tryba,M,Thalhammer,F,Schenk,P,Burgmann,H,Hollenstein,UM,Ratheiser,K,Breyer,S,Petit,L,Leger,A,Masson,F,Cochard,JF,Pinaquy,C,Erny,P,Giles,LJ,Johnson,Z,Phillips,GJ,Davies,JG,Olliff,CJ,McLuckie,A,Tsamis,S,Pikoulis,E,Theos,C,Banos,D,Koulouvaris,P,Joynt,GM,Lipman,J,Gomersall,CD,Young,RJ,Wong,E,Gin,T,Klarin,B,Johansson,M-L,Larsson,A,Jeppsson,B,Bertolissi,M,Bassi,F,Stögbauer,R,Hermann,C,Gill,R,Donais,K,Ryan,JJ,Ellis,CG,Barr,J,Prueckner,S,Safar,P,Thisherman,S,Stezoski,J,Eshel,G,Endo,S,Kasai,T,Yamada,Y,Inoue,Y,Taniguchi,S,Inada,K,Ikeda,K,Ikeda,T,Cohen,J,Aharon,A,Singer,P,Metcalf,K,Lisander,B,Garbino,J,Pichna,P,Lew,D,Pittet,D,Romand,J-A,Bateman,RM,Jagger,JE,Sharpe,MD,Ellis,CG,Alivizatos,V,Scarpetas,S,Delidimitri,D,Athanasopoulos,P,Hersch,M,Scott,JA,Cepinskas,G,Ostermann,M,Mehta,S,McCormack,DG,Sibbald,WJ,Tesinsky,P,Staudinger,T,Rusavy,Z,Kordova,H,Jankovec,Z,Karova,R,Baek,S-H,Yun,S-S,Chang,H-W,Kwak,J-Y,Kim,J-H,Kwun,K-B,Livianu,J,Blecher,S,Orlando,JMC,Proença,J O,Haney,MF,Johansson,G,Häggmark,S,Biber,B,Kýlýçaslan,N,Kocaman,G,Branson,RD,Campbell,RS,Ottaway,M,Johannigman,JA,Mion,G,Koulmann,P,LeGulluche,Y,Huebner,N,Rees,W,Boeckelmann,M,Rittel,S,Warnecke,H,Christmann,U,Larsson,A,Svanborg,I,Lobo,SMA,Fialho,PS,Borim,AA,Brienzc,SLA,Castilho,VG,Polachini,CA,Palchetti,JC,Lorente,L,Martin,M,Mledina,R,Valencia,JJ,Mujika,J,Jimenez,A,Hardman,JG,Kula,R,Májek,M,Reiger,J,Grimm,G,Pivetti,S,Navone,F,Tartaglino,B,Urbino,R,Gai,V,Prasad,B,Giles,S,Gao Smith,IF,Roosen,J,Frans,E,Wilmer,A,Vanderschueren,S,Bobbaers,H,Kindgen-Milles,D,Gabriel,A,Buhl,R,Böhner,H,Müller,E,Piagnerelli,M,Carlier,E,Jamart,S,Zouaoui Boudjeltia,K,Lejeune,P,Wehler,M,Strauß,R,Bost,A,Geise,A,Müller,A,Meyer,M,Hahn,EG,Esquinas,A,González,G,Del Baño,M,Jara,P,Rodríguez,M,Garciá,F,Carrillo,A,Ladakis,C,Myrianthefs,P,Lappas,V,Filndisis,G,Damianos,A,Pactitis,S,Baltopoulus,G,Williams,P,Mann,S,Rokyta,R,Hora,P,Nalos,M,Ruzicka,J,Matejovic,M,Novak,I,Sramek,V,Meregalli,AF,Sant'Anna,UL,Oliveira,ES,Friedman,G,McRae,RJ,Urbino,R,Antro,C,Pivetti,S,Tartaglino,B,Gregoretti,MG,Bonetto,C,Gai,V,Hatherill,M,McIntyre,A,Wattie,M,Murdoch,IA,Ferrand,E,Robert,R,Ingrand,P,and the LATERA group,Esquinas,A,González,D,Carrillo,A,Del Baño,M,Rodríguez,M,García,F,Jara,P,Deschner,N,Rieg,S,Häberle,H,Dieterich,H-J,Principi,T,Pantanetti,S,Carletti,P,Adrario,E,Pelaia,P,Gomersall,CD,Tan,PY,Joynt,G M,Buckley,T A,Wong,E,Lewejohann,J-C,Düpree,H-J,Gleiβ,J,Lewejohann,S,Muhl,E,Bruch,H-P,Grmec,S,Piberl,S,Gasparovic,V,Mentzelopoulos,SD,Tsitsika,MV,Balanika,MP,Joufi,MJ,Karamichali,EA,Nel,L,Watts,A,Potter,D,Buxton-Thomas,M,O'Grady,J,Heaton,N,de la Torre-Prados,MV,García-Alcántara A,A,Poullet-Brea,A,Reina-Artacho,C,Soler-García,A,Ciaglia,P,Marx,W,Jonas,MM,Kelly,FE,Linton,NWF,Linton,RAF,O'Brien,TK,Band,DM,Gionis,D,Moustaki,M,Beka,Z,Tsoutsou,A,Ourani,E,Papadatos,J,Kokkinis,K,Vrettos,T,Lefkaditi,K,Manolopoulou,P,Zbouki,K,Delia Rocca,G,Pompei,L,Coccia,C,Costa,MG,Ruberto,F,Pugliese,F,Martins,PS,Blecher,S,Karnik,A,Freeman,JW,Kerner,T,Deja,M,Ahlers,O,Grosse,E,Lohbrunner,H,Löffel,J,Riess,H,Wust,P,Gerlach,H,Shaikh,L,Stuart,H,Rhodes,A,Chang,for the RIP Group,RW,Yasumoto,K,Kagami,I,Ruggieri,CG,Passarello,P,Pettoni Possenti,M,Rambelli,G,Ruggeri,F,Sanseverino,M,Nastasi,M,Shaikh,L,Stuart,H,Rhodes,A,Chang,RW,for the RIP Users Group,Kalloghlian,AK,Pittappilly,BM,Matthews,NT,Sakka,SG,Meier-Hellmann,A,Reinhart,K,Novak,I,Hora,P,Bilek,M,Suchy,M,Rokyta,R,Sramek,V,Rajah,J,Riera-Fanego,J,Keeton,J,Ramjee,A,Bhana,R,Hon,H,Sakka,SG,Meier-Hellmann,A,Reinhart,K,Hora,P,Bilek,M,Suchy,M,Rokyta,R,Novak,I,Sramek,V,Via,G,Olivei,M,Palo,A,Neri,S,Ragni,G,Bertolini,M,Fusilli,N,Capra-Marzani,F,Rodi,G,lotti,G,Braschi,A,Marx,G,Burczyk,C,Cobas Meyer,M,Vangerow,B,Maassen,N,Gratz,KF,Leuwer,M,Rueckoldt,H,Janssens,U,Graf,C,Graf,J,Hanrath,P,Yassin,MY,Hansard,N,Gaillard,G,Holland,P,Truscott,JG,Oldroyd,B,Evans,JA,Olivei,M,Via,G,Palo,A,Neri,S,Maggio,G,Mediani,T,Galbusera,C,Belliato,M,Haeusler,E,Iotti,G,Braschi,A,Kiefer,P,Tugtekin,I,Putzke,M,Brahct,H,Geldner,G,Vogt,J,Weiβ,M,Wiedeck,H,Georgieff,M,Radermacher,P,Uttman,L,Sigurdsson,S,Jonson,B,Boyle,NH,Roberts,PC,McLukie,A,Giles,L,Beale,RJ,Mason,RC,Campbell,RS,Sinamban,RP,Johannigman,JA,Luchette,FA,Frame,SB,Davis,K Jr,Branson,RD,Boyle,NH,Roberts,PC,McLuckie,A,Owen,WJ,Beale,RJ,Mason,RC,Malbrain,MLNG,Rashid,HI,van Heerden,N,Taylor,PR,Edmondson,RA,Malbrain,MLNG,Baguneid,MS,Bukhari,M,Fulford,PE,Howe,M,Bigley,G,McMahon,RFT,Eddleston,J,Walker,MG,Constantin,JM,Gindre,G,Segrell-Therre,JD,Bazin,JE,Schoeffler,P,Burgener,D,Svensson,M,Oi,Y,Jolliet,P,Strasser,S,Hadengue,A,Aneman,A,Zobel,G,Rödl,S,Urlesberger,B,Bermoser,M,Schwinger,W,Dacar,D,Knez,I,Vogelsang,H,Uhlig,T,Heinze,H,Schmucker,P,Zobel,G,Dacar,D,Knez,I,Rödl,S,Salaymeh,V,Knez,A,Gradnitzer,E,Aneman,A,Burgener,D,Svensson,M,Oi,Y,Hadengue,A,Sramek,V,Rokyta,R,Novak,I,Nalos,M,Hora,P,Ruzicka,J,Matejovic,M,Snygg,J,Åneman,A,Pettersson,A,Fändriks,I,Tibby,SM,Hatherill,M,Wright,SM,Postle,AD,Reid,KB,Murdoch,IA,Thorburn,K,Roberts,P,Hatherill,M,Murdoch,I,Liangui,F,Xianjian,G,Penno,S,Reiner,G,Carbonatto,M,Bodenbender,L,Boland,P,Abel,KJ,Esquinas,A,González,D,Carrillo,A,Del 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Donaher,J,Weinberg,RA,Sambrook,J,Ghimenti,C,Sensi,E,Iandolo,D,Cipollini,G,Ricci,S,Conte,PF,Bevilacqua,G,Caligo,MA,Mote,P,Clarke,C,Lange,CA,Shen,T,Horwitz,KB,Suo,Z,Nesland,JM,Stal,O,Akerberg,L,Nordenskjold,B,Olsson,B,Rutqvist,LE,Skoog,L,Giannos,J,Ginopulos,P,Westman,G,Pantel,K,Maass,N,Nagasaki,K,Jacobs,VR,Jonat,W,Berns,EMJJ,van Staveren,IL,Verhoog,L,Foekens,JA,Klijn,JGM,Leigh,S,Martínez-Ferrandis,JI,Vega,A,Marín-Garcia,P,Barros,F,Chaves,FJ,Carracedo,A,Armengod,ME,Chirivella,I,Lluch,A,García-Conde,J,Cervantes,A,Chiappini,F,Matita,MC,De Sole,P,Fresu,R,Frigieri,L,Fuso,L,Pagliari,G,Stiletto,RJ,Kirchner,G,Ziering,E,Meisner,M,Tschaikowsky,K,Hutzler,A,Schick,C,Schmidt,J,Fransen,EJ,Maessen,JG,Elenbaas,TWO,van Aamhem,EEHL,Stobberingh,E,Visschers,H,van Diejen-Visser,MP,Seghaye,MC,Schumacher,K,Grabitz,RG,Busse,S,Däbritz,S,Messmer,BJ,von Bernuth,G,Duchateau,J,Cerny,V,Zivny,P,Dostal,P,Parizkova,R,de la Torre,MV,García-Alcántara,A,Poullet,A,Toro,R,Estecha,MA,Hernández,A,Carpintero,JL,Endo,S,Kasai,T,Takakuwa,T,Nakae,H,Yamada,Y,Inada,K,Taniguchi,S,Eachempati,SR,Peterson,TJ,Eash,DR,Nayduch,D,Reed,RL,Adamik,B,Pliskowska,B,Berezowicz,PS,Kübler,J,Golêbiowska,B,Kübler,A,Bernal,W,Wendon,J,Takala,A,Jousela,I,Takkunen,O,Olkkola,KT,Jansson,S-E,Leirisalo-Repo,M,Repo,H,Hsu,S-T,Hsu,C-H,Chang,C-J,Hoong Thye,C,Rajamanon mani,R,Ong Siok Yan,G,Qvist,R,Kajba,S,Djordjevic,S,Oberhoffer,M,Russwurm,S,Stonans,I,Stonane,E,Vogelsang,H,Junker,U,Jäger,L,Reinhart,K,Afanasyev,LM,Ignatyuk,YM,Kreines,VM,Sharovarnikov,SI,Kravchenko,AI,Vlasov,VM,Vaizov,VH,Ustyantseva,IM,Pertseva,TA,Usenko,LV,Cherkasova,OG,De La 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期刊：Cancer Research影响因子：16.600
时间：2000起止号：2000;2(Suppl 1):P2
doi：10.1186/bcr138

Abstract

The present study demonstrates that fibroblasts associated with carcinomas stimulate tumor progression of initiated nontumorigenic epithelial cells both in an in vivo tissue recombination system and in an in vitro coculture system. Human prostatic carcinoma-associated fibroblasts grown with initiated human prostatic epithelial cells dramatically stimulated growth and altered histology of the epithelial population. This effect was not detected when normal prostatic fibroblasts were grown with the initiated epithelial cells under the same experimental conditions. In contrast, carcinoma-associated fibroblasts did not affect growth of normal human prostatic epithelial cells under identical conditions. From these data, we conclude that in this human prostate cancer model, carcinoma-associated fibroblasts stimulate progression of tumorigenesis. Thus, carcinoma-associated fibroblasts can direct tumor progression of an initiated prostate epithelial cell.

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